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| 1 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 2 | Non-dysraphic intramedullary spinal cord lipoma显示文摘 | Qureshi NA Akram M Ghaffar A | 2006 | J Coil Physicians Surg Pak2006，16，4： | 1 |
| 3 | Enhanced purinergic con- tractile responses and P2X1 receptor expression in detrusor muscle during cycles of hypoxia-glucopenia and reoxygenation 显示文摘 | Elliott RA Tonnu A Ghaffar N | 2013 | Exp Physiol2013，98，： | 1 |
| 4 | The conditions required for the propagation of a cathode-directed positive streamer in air显示文摘 | Allen N L Ghaffar A | 1995 | J Phys D:Appl Phys1995，28，2： | 1 |
| 5 | 3 - D nonlinear seismic behavior of cable - stayed bridges显示文摘 | ABDEL - GHAFFAR A M NAZMY A S | 1991 | Structure Engineering ASCE1991，117，11： | 1 |
| 6 | 显示文摘 | Ghaffar A Sadrmohaghegh C | 1981 | Polymer1981，，17： | 1 |
| 7 | Heterologous expression of a gene for thermostable xylanase from Chaetomium thermophilum in Pichia pastoris GSll5显示文摘 | GHAFFAR A KttAN S A MUKItTAR Z | 2011 | Molecular Biology Reports2011，38，5： | 1 |
| 8 | Loc alization of metallothionein in the brain of rat and mouse显示文摘 | Nishimura H Ghaffar A | 1992 | J Histochem Cytochem1992，40，2： | 1 |
| 9 | The conditions required for thepropagation of a cathode-directed positive streamer in air显示文摘 | ALLEN N L GHAFFAR A | 1995 | Journal of Physics D - Applied Physics1995，28，2： | 1 |
| 10 | Maleic acid/phenylene diamine adducts as new antioxidant amide polymers for rubber (NR and SBR) vulcanizates 显示文摘 | M A Abd E1- Ghaffar D E El- Nashar E A M Youssef | 2003 | Polymer Degradation and Stability2003，82，1： | 1 |
| 11 | Radiation-induced graft copolyme- rization of acrylic acid/acrylonitrile onto LDPE and PET films and its biodegradability 显示文摘 | EL-ARNAOUTY M B ABDEL GHAFFAR A M EL- SHAFEY H M | 2008 | Journal of Applied Polymer Science2008，107，2： | 1 |
| 12 | Hight performance anticorrosive paint formulations base on phosphate pigments 显示文摘 | M A ABD EL - GHAFFAR E A M YOUSSEF N M ABMED | 2004 | Pigments & Resin Technology2004，33，6： | 1 |
| 13 | The conditions required for the propagation of a cathode-directed positive streamer in air显示文摘 | Allen N L Ghaffar A | 1995 | Journal Of Physics D-Applied Physics1995，28，2： | 1 |
| 14 | Non - linear earthquake - re- sponse analysis of long - span cable - stayed bridges: theory显示文摘 | Nazmy A S Abdel - Ghaffar A M | 1990 | Earthquake Engineering and Structural Dynamics1990，19，1： | 1 |
| 15 | Effect of biochar aging on surface characteristics and adsorption behavior of dialkyl phthalates显示文摘 | GHAFFAR A GHOSH S LI F | 2015 | Environmental Pollution2015，206，： | 1 |
| 16 | The variation with temperature of positive streamer properties in air显示文摘 | Allen N L Ghaffar A | 1995 | J Phys D:Appl Phys1995，28，2： | 1 |
| 17 | Effects of ground motion spatial variability on the response of cable - stayed bridges显示文摘 | Nazrny A S Abdel- Ghaffar A M | 1992 | Earth- quake Engineering and Structural Dynarnics1992，21，1： | 1 |
| 18 | Water purification by electrical discharges显示文摘 | Malik M A Ghaffar A Malik S A | 2001 | Plasma Sources Science and Technology2001，10，1： | 1 |
| 19 | Non - linear earthquake - re- sponse analysis of long - span cable - stayed bridges : applications 显示文摘 | Nazmy A S Abdel - Ghaffar A M | 1990 | Earthquake Engineering and Structural Dynamics1990，19，1： | 1 |
| 20 | Water purification by electrical discharges显示文摘 | Malik MA Ghaffar A Malik SA | | Plasma Sources Science and Technology0，10，： | 1 |
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