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| 1 | Hematological disorders and pulmonary hypertension显示文摘Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH. | Rajamma Mathew Jing Huang Joseph M Wu John T Fallon Michael H Gewitz | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 2 | Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group显示文摘 | Wilson W Taubert KA Gewitz M | 2007 | Circulation2007，116，15： | 1 |
| 3 | Prevention of Infective Endocarditis Guidelines From the American Heart Association: A Guideline From the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group显示文摘 | Wilson W Taubert KA Gewitz M | 2007 | Circulation2007，116，15： | 1 |
| 4 | Prevention of infective endocarditis:guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever,Endocarditis,and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology,Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group显示文摘 | Wilson W Taubert KA Gewitz M | 2007 | Circulation2007，116，15： | 1 |
| 5 | Treatment of pulmonary hy- pertension in children with chronic lung disease with newer oral therapies显示文摘 | Krishnan U Krishnan S Gewitz M | 2008 | Pediatr Cardiol2008，29，6： | 1 |
| 6 | Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association 显示文摘 | Newburger J W Takahashi M Gerber M A Gewitz M H Tani L Y Burns J C | 2004 | Circulation2004，110，： | 1 |
| 7 | Diagnosis treatment, and long-term management of Kawasaki disease: a statement for health professi-onals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on CardiovascularDisease in the Young, American Heart Association显示文摘 | Newburger JW Takahashi M Gerber MA Gewitz MH Tani LY Burns JC | 2004 | Pediatrics2004，114，： | 1 |
| 8 | Prevention of infective endocarditis: Guidelines from the American Heart Association显示文摘 | Wilson W Taubert KA Gewitz M | 2007 | Crculation2007，116，15： | 1 |
| 9 | Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association 显示文摘 | Newburger JW Takahashi M Gerber MA Gewitz MH Tani LY Burns JC | 2004 | Pediatrics2004，114，6： | 1 |
| 10 | Diagnosis,treatment, and long-term management of Kawasaki disease : a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association 显示文摘 | Newburger JW Takahashi M Gerber MA Gewitz MH Tani LY Burns JC | 2004 | Circulation2004，110，17： | 1 |
| 11 | Prevention of infective endocarditis显示文摘 | Wilson W Taubert KA Gewitz M | 2007 | Circulation2007，116，15： | 1 |
| 12 | Prevention of infective en- docarditis: guidelines from the American Heart Association:A guide- line from the American Heart Association Rheumatic Fever, Endo- carditis,and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young,and the Council on clinical Cardiology, Coun- cil on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group 显示文摘 | Wilson W Taubert KA Gewitz M | 2007 | Circulation2007，116，15： | 1 |
| 13 | Kawasaki disease: diagnosis, management, and long-term implications显示文摘 | Satou G M Giamelli J Gewitz M H | 2007 | Cardiol Rev2007，15，4： | 1 |
| 14 | Unique features of infective endocarditis in childhood 显示文摘 | FERRIERI P GEWITZ M H GERBER M A | 2002 | Circulation2002，105，17： | 1 |
| 15 | Kawasaki disease:diagnosis,management,and long-term implications显示文摘 | Satou G M Giamelli J Gewitz M H | 2007 | Cardiol Rev2007，15，4： | 1 |
| 16 | Prevention of infectiveendocarditis:guidelines from the American Heart Association:aguideline from the American Heart Association Rheumatic Fever,Endocarditis,and Kawasaki Disease Committee,Council onCardiovascular Disease in the Young,and the Council on ClinicalCardiology,Council on Cardiovascular Surgery and Anesthesia,andthe Quality of Care and Outcomes Research InterdisciplinaryWorking Group显示文摘 | Wilson W Taubert KA Gewitz M | 2007 | Circulation2007，116，15： | 1 |
| 17 | Prevention ofinfective endocarditis:guidelines from the American HeartAssociation:a guideline from the American Heart Associa-tion Rheumatic Fever,Endocarditis,and Kawasaki Di-sease Committee,Council on Cardiovascular Disease in theYoung,and the Council on Clinical Cardiology,Council onCardiovascular Surgery and Anesthesia,and the Quality ofCare and Outcomes Research Interdisciplinary WorkingGroup显示文摘 | Wilson W Taubert KA Gewitz M | 2007 | Circulation2007，116，15： | 1 |
| 18 | Prevention of infective endocardi- tis:guidelines from the American Heart Association:a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia,and the Quality of Care and Outcomes Research Interdisciplinary Working Group显示文摘 | Wilson W Taubert KA Gewitz M | 2007 | J Am Dent Assoc2007，135，6： | 1 |
| 19 | Kawasaki disease diagnosis,man- agement and long-term implications显示文摘 | Satou G Giamelli J Gewitz M | 2007 | Cardiol Rev2007，15，4： | 1 |
| 20 | Echocardiographic characteristics of premature infants with ductus arteriosus显示文摘 | Johnson G L Breart G L Gewitz M H | | 0，，06： | 1 |
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