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| 1 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 2 | Is money the panace- a? Rewards for knowledge workers显示文摘 | GERGANA M CAMERON F | 2011 | International Journal of Productivity and Performance Management2011，60，8： | 1 |
| 3 | Absorptive Capacity: Valuing a Reconceptualization显示文摘 | Gergana Todorova Boris Durisin | 2007 | Academy of Management Review2007，32，3： | 1 |
| 4 | Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer显示文摘 | Christina Greenwood Gergana Metodieva Khalid Al-Janabi Berthold Lausen Louise Alldridge Lin Leng Richard Bucala Nelson Fernandez Metodi V. Metodiev | 2011 | Journal of Proteomics2011，，10： | 1 |
| 5 | Absorptive capability: valuing a reconceptualization显示文摘 | GERGANA TODOROVA BORIS BURISIN | 2007 | Academy of Management Review2007，32，3： | 1 |
| 6 | SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation显示文摘 | Gergana Dobreva Maria Chahrour Marcel Dautzenberg Laura Chirivella Benoit Kanzler Isabel Fari?as Gerard Karsenty Rudolf Grosschedl | 2006 | Cell2006，，5： | 1 |
| 7 | Absorptive capability: valuing a reconceptualization 显示文摘 | Gergana Todorova Boris Burisin | 2007 | Academy of Management Review2007，32，3： | 1 |
| 8 | Absorptive Capacity: Valuing a Reconceptualization 显示文摘 | Gergana Todorrova& Boris Durisin | 2007 | Academy of Management Review2007，32，3： | 1 |
| 9 | Absorptive capability: valuing a reconceptualization显示文摘 | Gergana Todorova Boris Burisin | 2007 | Academy of Management Review2007，32，3： | 1 |
| 10 | Photodynamic therapy with verteporfin in age-related macular degeneration:a systematic review of efficacy,safety,treatment modifications and pharmacoeconomic properties显示文摘 | Alan F.Cruess Gergana Zlatcva Andreas M.Pleil Barbara Wirostko | | 0，，02： | 1 |
| 11 | Momentum and credit rating显示文摘 | Avramov Doron Tarun Chordia Gergana Jostova Alexander Philipov | | 0，，5： | 1 |
| 12 | Anomalies and financial distress显示文摘 | Doron Avramov Tarun Chordia Gergana Jostova Alexander Philipov | 2012 | Journal of Financial Economics2012，，： | 1 |
| 13 | Absorptive Capability:Valuing a Reconceptualization显示文摘 | Gergana Todorova Boris Burisin | 2007 | Academy of ManagementReview2007，32，3： | 1 |
| 14 | Trafficking in persons and development:towards greater policy coherence 显示文摘 | Gergana Danailova- Trainor Frank Laczko | 2010 | InternatiOnal Migra- tion2010，48，4： | 1 |
| 15 | Absorptive Capacity: Valuing A Reconceptualization显示文摘 | Gergana Todorova Boris Durisin | 2007 | Academy of Management Review2007，，32： | 1 |
| 16 | The Sentence Fairy: a natural-language generation system to support children’s essay writing显示文摘 | Karin Harbusch Gergana Itsova Ulrich Koch Christine Kuhner | 2008 | Computer Assisted Language Learning2008，，4： | 1 |
| 17 | Influence of the intertropical convergence zone on the East Asian monsoon显示文摘 | GERGANA Y NORBERT R N JENS M | 2007 | Nature2007，445，7124： | 1 |
| 18 | Absorptive ca-pability: valuing a reconceptualization 显示文摘 | GERGANA TODOROVA BORIS BURISIN | 2007 | Academy ofManagement Review2007，32，3： | 1 |
| 19 | Liver dysfunction as a cytokine storm manifestation and prognostic factor for severe COVID-19显示文摘patients with or without preexisting liver disorders,posing a significant complication and mortality risk.During coronavirus disease 2019(COVID-19),abnormal liver function is typically observed.However,liver injury may occur because of the treatment as well.Ischemia,cytokine storm,and hypoxia were identified as the three major factors contributing to liver damage during COVID-19.Indeed,raised liver enzymes during hospitalizations may be attributed to medications used,as well as sepsis and shock.As a result,the proportion of hospitalized patients afflicted with COVID-19 and pathological liver biomarkers varies from 14%to 53%.Aminotransferases and bilirubin are found most often elevated.Usually,increased gamma-glutamyltransferase,alkaline phosphatase,and decreased serum albumin levels are demonstrated.Additionally,although there is no specific treatment for COVID-19,many of the drugs used to treat the infection are hepatotoxic.In this mini-review,we focus on how liver dysfunction can be one of the features associated with the COVID-19 cytokine storm.Furthermore,data show that liver injury can be an independent predictor of severe COVID-19,the need for hospitalization,and death. | Gergana Taneva Dimitar Dimitrov Tsvetelina Velikova | 2021 | World Journal of Hepatology2021，13，12： | 0 |
| 20 | Targeting α-synuclein by PD03 AFFITOPE■ and Anle 138b rescues neurodegenerative pathology in a model of multiple system atrophy:clinical relevance显示文摘Background:Misfolded oligomeric α-synuclein plays a pivotal role in the pathogenesis of a-synucleinopathies including Parkinson's disease and multiple system atrophy,and its detection parallels activation of microglia and a loss of neurons in the substantia nigra pars compacta.Here we aimed to analyze the therapeutic efficacy of PD03,a new AFFITOPE■ immunotherapy approach,either alone or in combination with Anle138b,in a PLP-α-syn mouse model.Methods:The PLP-α-syn mice were treated with PD03 immunotherapy,Anle138b,or a combination of two.Five months after study initiation,the mice underwent behavioral testing and were sacrificed for neuropathological analysis.The treatment groups were compared to the vehicle group with regard to motor performance,nigral neuronal loss,microglial activation and α-synuclein pathology.Results:The PLP-α-syn mice receiving the PD03 or Anle138b single therapy showed improvement of gait deficits and preservation of nigral dopaminergic neurons associated with the reduced α-synuclein oligomer levels and decreased microglial activation.The combined therapy with Anle138b and PD03 resulted in lower lgG binding in the brain as compared to the single immunotherapy with PD03.Conclusions:PD03 and Anle138b can selectively target oligomeric α-synuclein,resulting in attenuation of neurodegeneration in the PLP-α-syn mice.Both approaches are potential therapies that should be developed further for disease modification in α-synucleinopathies. | Miguel Lemos Serena Venezia Violetta Refolo Antonio Heras-Gavin Sabine Schmidhuber Armin Giese Andrei Leonov Sergey Ryazanov Christian Griesinger Gergana Galabova Guenther Safer Gregor Karl Wenning Nadia Stefanova | 2020 | Translational Neurodegeneration2020，9，3： | 0 |
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