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| 1 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 2 | Effects of porcine follicular fluid and oviduct conditioned media on maturation and fertilization of porcine oocytes in vitro显示文摘 | Georgios Vatzias Daniel R Hagen | 1999 | Biol Reprod1999，28，： | 1 |
| 3 | Integrated uhrasound and biochemical screening for trisomy 21 using fetal nuchal translucency, absent fetal nasal bone, free β-hCG and PAPP-A at 11 to 14 weeks显示文摘 | Simona C Renu B Georgios R | 2003 | Prenat Diagn2003，，23： | 1 |
| 4 | Effects of porcine follicular fluid and oviduct - conditioned on maturation and fertilization of porcine oocytes in vitro显示文摘 | GEORGIOS V DANIEL R H | 1999 | Bio Reprod1999，60，： | 1 |
| 5 | Effects of porcine follicular fluid and oviduct conditioned media on maturation and fertilization of porcine oocytes in vitro显示文摘 | Georgios Vatzias Daniel R Hagen | 1999 | Biol Reprod1999，28，： | 1 |
| 6 | FamiLiaL cancer history in patients with carcinoma of the cervix uteri 显示文摘 | Lars C H Georgios R | 2002 | Eur J Obstet GynoL Reprod BioL2002，101，： | 1 |
| 7 | Familial cancer history in patients with carcinoma of the cervix uteri显示文摘 | Lars-Christian H Georgios R | 2002 | Eur J Obstet Gynecol Reprod Biol2002，101，： | 1 |
| 8 | Safety and efficacy of ultrasound-enhanced thrombolysis:a comprehensive review and meta-analysis of randomized and nonrandomized studies显示文摘 | Georgios T Jürgen E Marc R | 2010 | Stroke2010，41，2： | 1 |
| 9 | Familial cancer history in patients with carcinoma of the cervix uteri显示文摘 | Lars-Christian H Georgios R | 2002 | Eur J Obstet Gynecol Reprod Biol2002，101，： | 1 |
| 10 | Familial cancer history in patients with carcinoma of the cervix uteri显示文摘 | Lars-Christian H Georgios R | 2002 | European Journal of Obstetrics- & Gynecology and Reproductive Biology2002，101，： | 1 |
| 11 | Vibrational investigation of indigo–palygorskite association(s) in synthetic Maya blue显示文摘 | Constantinos Tsiantos Maria Tsampodimou George H. Kacandes Manuel Sánchez del Río Vassilis Gionis Georgios D. Chryssikos | 2012 | Journal of Materials Science2012，，7： | 1 |
| 12 | Familial cancer history in patients with carcinoma of the cervix uteri显示文摘 | Lars-Christian H Georgios R | 2002 | Eur J Obstet Gynecol Reprod Biol2002，101，： | 1 |
| 13 | Sulforaphane increases drug - mediated eytotoxicity toward cancer stem - like cells of pan- creas and prostate 显示文摘 | Georgios K Sabrina L Vanessa R | 2011 | Mol Ther2011，19，1： | 1 |
| 14 | Extended hepatectomy for intrahepatic cholangiocellular carcinoma显示文摘 | Hauke Lang MD Georgios C Sotiropoulos MD Nils R Fruhauf MD | 2005 | Ann Surg2005，241，： | 1 |
| 15 | CHARMM:the biomolecular simulation program显示文摘 | Brooks Bernard R Brooks Charles L MacKerell Alexander D Nilsson Lennart Petrella R J Roux Beno?t Won Youngdo Archontis Georgios Bartels Christoph Boresch Stefan | | 0，，： | 1 |
| 16 | Role of the H1 haplotype of microtubule-associated protein tau (MAPT) gene in Greek patients with Parkinson' s disease显示文摘 | Nikolaos R Juliane B Georgios T | 2009 | Bmc Neuroscience2009，5，2： | 1 |
| 17 | Familial cancer history in patients with carcinoma of the cervix uteri显示文摘 | Lars-Christian H Georgios R | 2002 | Eur J Obstet Gynecol Reprod Biol2002，101，1： | 1 |
| 18 | Effects of porcine follicular fluid and oviduct conditioned media on maturation and fertilization of porcine oocytes in vitro显示文摘 | Georgios Vatzias Daniel R Hagen | 1999 | Biol Reprod1999，，28： | 1 |
| 19 | Effects of porcine follicular fluid and oviduct conditioned media on maturation and fertilization of porcine oocytes in vitro显示文摘 | Georgios Vatzias Daniel R Hagen | 1999 | Biol Reprod1999，28，： | 1 |
| 20 | Extended hepatectomy for intrahepatic cholangiocellular carcinoma显示文摘 | Hauke Lang MD Georgios C Sotiropoulos MD Nils R Fruhauf MD | 2005 | Ann Surg2005，241，： | 1 |
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