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1篇 您的检索式：作者名="George Merhej"

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		题名	作者	年代	出处	被引量
	1	Cancer resistance to immunotherapy: What is the role of cancer stem cells?显示文摘Immunotherapy is an emerging form of cancer therapy that is associated with promising outcomes.However,most cancer patients either do not respond to immunotherapy or develop resistance to treatment.The resistance to immunotherapy is poorly understood compared to chemotherapy and radiotherapy.Since immunotherapy targets cells within the tumor microenvironment,understanding the behavior and interactions of different cells within that environment is essential to adequately understand both therapy options and therapy resistance.This review focuses on reviewing and analyzing the special features of cancer stem cells(CSCs),which we believe may contribute to cancer resistance to immunotherapy.The mechanisms are classified into three main categories:mechanisms related to surface markers which are differentially expressed on CSCs and help CSCs escape from immune surveillance and immune cells killing;mechanisms related to CSC-released cytokines which can recruit immune cells and tame hostile immune responses;and mechanisms related to CSC metabolites which modulate the activities of infiltrated immune cells in the tumor microenvironment.This review also discusses progress made in targeting CSCs with immunotherapy and the prospect of developing novel cancer therapies.	Gourab Gupta George Merhej Shakthika Saravanan Hexin Chen	2022	Cancer Drug Resistance2022，5，4：	0

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