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| 1 | Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease显示文摘In 2018,the pan-Janus kinase(JAK)inhibitor tofacitinib was launched for the treatment of ulcerative colitis(UC).Although tofacitinib has proven efficacious in patients with active UC,it failed in patients with Crohn’s disease(CD).This finding strongly hints at a different contribution of JAK signaling in both entities.Here,we review the current knowledge on the interplay between the JAK/signal transducer and activator of transcription(STAT)pathway and inflammatory bowel diseases(IBD).In particular,we provide a detailed overview of the differences and similarities of JAK/STAT-signaling in UC and CD,highlight the impact of the JAK/STAT pathway in experimental colitis models and summarize the published evidence on JAK/STAT-signaling in immune cells of IBD as well as the genetic association between the JAK/STAT pathway and IBD.Finally,we describe novel treatment strategies targeting JAK/STAT inhibition in UC and CD and comment on the limitations and challenges of the new drug class. | Friederike Cordes Dirk Foell John Nik Ding Georg Varga Dominik Bettenworth | 2020 | World Journal of Gastroenterology2020，26，28： | 16 |
| 2 | CREMa overexpression decreases IL-2 production,induces a TH17 phenotype and accelerates autoimmunity显示文摘Dear Editor,External cytokines produced by cells of the innate immune system induce the dif-ferentiation of CD4+T cells into helper T cell subsets with distinct functions and cytokine profiles.Apart from TH1 and TH2 cells a third subset of helper T cells has been described,which is characterized by increased expression of IL-17A,IL-17F,IL-21 and IL-22(TH17 cells). | Ralph Lippe Kim Ohl Georg Varga Thomas Rauen Jose C.Crispin Yuang-Taung Juang Stefanie Kuerten Frank Tacke Marc Wolf Kirsten Roebrock Thomas Vogl Eva Verjans Nora Honke Jan Ehrchen Dirk Foell Boris Skryabin Norbert Wagner George C.Tsokos Johannes Roth Klaus Tenbrock | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 3 | Apolipoprotein E Induces Antiinflammatory Phenotype in Macrophages显示文摘 | Daniel Baitsch Hans H. Bock Thomas Engel Ralph Telgmann Carsten Müller-Tidow Georg Varga Martine Bot Joachim Herz Horst Robenek Arnold von Eckardstein Jerzy-Roch Nofer | 2011 | Arteriosclerosis, Thrombosis, and Vascular Biology2011，，5： | 1 |
| 4 | Role of complement in the pathomechanism of atherosclerotic vascular diseases显示文摘 | Gábor Széplaki Lilian Varga George Füst Zoltán Prohászka | 2009 | Molecular Immunology2009，，： | 1 |
| 5 | Alkylguanidines as catalysts for the transesterification of rapeseed oil 显示文摘 | Ulf Schuchardt Rogerio Matheus Vargas Georges Gelbard | 1995 | Journal of Molecular Catalysis A: Chemical1995，99，： | 1 |
| 6 | Transesterification of soybean oil catalyzed by alkylguanidines heterogenized on different substituted polystyrenes 显示文摘 | Ulf Schuchardt Rogerio Matheus Vargas Georges Gelbard | 1996 | Journal of Molecular Catalysis A: Chemical1996，109，： | 1 |
| 7 | Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat显示文摘 | Karoly Varga George Kunos | 1990 | Brain Res1990，535，2： | 1 |
| 8 | Intrinsic defects on a TiO 2 (110)(1×1) surface and their reaction with oxygen: a scanning tunneling microscopy study显示文摘 | Ulrike Diebold Jeremiah Lehman Talib Mahmoud Markus Kuhn Georg Leonardelli Wilhelm Hebenstreit Michael Schmid Peter Varga | 1998 | Surface Science1998，，1： | 1 |
| 9 | Identification of abnormal tribological regimes using a microphone and semi-supervised machine-learning algorithm显示文摘Functional surfaces in relative contact and motion are prone to wear and tear,resulting in loss of efficiency and performance of the workpieces/machines.Wear occurs in the form of adhesion,abrasion,scuffing,galling,and scoring between contacts.However,the rate of the wear phenomenon depends primarily on the physical properties and the surrounding environment.Monitoring the integrity of surfaces by offline inspections leads to significant wasted machine time.A potential alternate option to offline inspection currently practiced in industries is the analysis of sensors signatures capable of capturing the wear state and correlating it with the wear phenomenon,followed by in situ classification using a state-of-the-art machine learning(ML)algorithm.Though this technique is better than offline inspection,it possesses inherent disadvantages for training the ML models.Ideally,supervised training of ML models requires the datasets considered for the classification to be of equal weightage to avoid biasing.The collection of such a dataset is very cumbersome and expensive in practice,as in real industrial applications,the malfunction period is minimal compared to normal operation.Furthermore,classification models would not classify new wear phenomena from the normal regime if they are unfamiliar.As a promising alternative,in this work,we propose a methodology able to differentiate the abnormal regimes,i.e.,wear phenomenon regimes,from the normal regime.This is carried out by familiarizing the ML algorithms only with the distribution of the acoustic emission(AE)signals captured using a microphone related to the normal regime.As a result,the ML algorithms would be able to detect whether some overlaps exist with the learnt distributions when a new,unseen signal arrives.To achieve this goal,a generative convolutional neural network(CNN)architecture based on variational auto encoder(VAE)is built and trained.During the validation procedure of the proposed CNN architectures,we were capable of identifying acoustics signals corresponding to the normal and abnormal wear regime with an accuracy of 97%and 80%.Hence,our approach shows very promising results for in situ and real-time condition monitoring or even wear prediction in tribological applications. | Vigneashwara PANDIYAN Josef PROST Georg VORLAUFER Markus VARGA Kilian WASMER | 2022 | Friction2022，10，4： | 1 |
| 10 | Transesterification of soybean oil catalyzed by alkylguanidines heterogenized on different substituted polystyrenes显示文摘 | Ulf Schuchardt Rogerio Matheus Vargas Georges Gelba-rd | 1996 | Journal of Molecular Catalysis A:Chemical1996，109，： | 1 |
| 11 | Transesterification of soybean oil catalyzed by alkylguanidines heterogenized on different substituted polystyrenes显示文摘 | Ulf Schuchardt Rogerio Matheus Vargas Georges Gelbard | 1996 | Journal of Molecular Catalysis A: Chemical1996，109，： | 1 |
| 12 | Longs short-term based semi-supervised memory encoder-decoder for early prediction of failures in self-lubricating bearings显示文摘The existing knowledge regarding the interfacial forces,lubrication,and wear of bearings in real-world operation has significantly improved their designs over time,allowing for prolonged service life.As a result,self-lubricating bearings have become a viable alternative to traditional bearing designs in industrial machines.However,wear mechanisms are still inevitable and occur progressively in self-lubricating bearings,as characterized by the loss of the lubrication film and seizure.Therefore,monitoring the stages of the wear states in these components will help to impart the necessary countermeasures to reduce the machine maintenance downtime.This article proposes a methodology for using a long short-term memory(LSTM)-based encoder-decoder architecture on interfacial force signatures to detect abnormal regimes,aiming to provide early predictions of failure in self-lubricating sliding contacts even before they occur.Reciprocating sliding experiments were performed using a self-lubricating bronze bushing and steel shaft journal in a custom-built transversally oscillating tribometer setup.The force signatures corresponding to each cycle of the reciprocating sliding motion in the normal regime were used as inputs to train the encoder-decoder architecture,so as to reconstruct any new signal of the normal regime with the minimum error.With this semi-supervised training exercise,the force signatures corresponding to the abnormal regime could be differentiated from the normal regime,as their reconstruction errors would be very high.During the validation procedure for the proposed LSTM-based encoder-decoder model,the model predicted the force signals corresponding to the normal and abnormal regimes with an accuracy of 97%.In addition,a visualization of the reconstruction error across the entire force signature showed noticeable patterns in the reconstruction error when temporally decoded before the actual critical failure point,making it possible to be used for early predictions of failure. | Vigneashwara PANDIYAN Mehdi AKEDDAR Josef PROST Georg VORLAUFER Markus VARGA Kilian WASMER | 2023 | Friction2023，11，1： | 0 |
| 13 | 采访安德烈·波切利显示文摘了解这位著名歌剧演唱家的生活与工作,安德烈·波切利是名律师?在他作为史上最卖座的歌剧演唱家而轰动全球之前,这位意大利超级巨星在比萨大学获得了法律学位,并担任公设辩护人。波切利从诉讼转移到歇剧,就是因为这位盲人歌手知道自己心系歌唱,而非分析书面证词。 | George Varga OLIVE CHU(PAGE DESIGN) | 2022 | 空中英语教室(高级版.彭蒙惠英语)2022，，11： | 0 |
| 14 | Comprehensive review of tribometer dynamics-Cycle-based data analysis and visualization显示文摘Tribologists often rely on triboexperiments to investigate factors that affect a tribosystem.The inherent dynamic behavior of the respective tribometer setups and its effect on data interpretation remain often unknown.In this study,a comprehensive analysis of sensor data obtained from lubricated and dry triboexperiments is performed.Data are generated on a pin-on-disc test rig with a silicon nitride ball on a steel disc contact with a rotation frequency of~3 Hz.High-speed acquisition of sensor data up to 5 kHz is performed to resolve changes in the data within individual cycles.The characteristic frequencies of the system and their temporal evolution are determined via time--frequency analysis,which reveals periodic patterns in the sensor data.Cycle-based data evaluation allows the detection of localized events and changes during an operation and considerably reduces the apparent measurement uncertainty,as compared with an unreduced dataset.The data analysis and visualization routines presented herein may serve as a prototype for further application to tribometer setups. | Josef PROST Guido BOIDI Thomas LEBERSORGER Markus VARGA Georg VORLAUFER | 2022 | Friction2022，10，5： | 0 |
| 15 | 圣迭戈的瑞迪贝壳音乐厅 耗资8500万美元的瑞迪贝壳音乐厅投入使用,带领圣迭戈交响乐团奏响新乐章显示文摘每当欧文·雅各布斯想到好主意时,不管难度有多大,大家都会听。即便他的想法可能带来重大变革、要花将近20年才能看到成果,而且花费金额高达8位数,那仍是可以克服的挑战。雅各布斯认为,圣迭戈交响乐团应该有一个全年无休的永久户外表演场地。如今,圣迭戈与其他各地民众将能听到、且能看到雅各布斯的想法开花结果。 | George Varga 徐佩仪(译) | 2022 | 空中英语教室(高级版.彭蒙惠英语)2022，，3： | 0 |
| 16 | N-acetyl cysteine alters the genotoxic and estrogenic properties of Alternaria toxins in naturally occurring mixtures显示文摘It is unclear if complex mycotoxin mixtures produced by Alternaria spp.act estrogenic and/or genotoxic under physiological conditions,particularly considering the co-occurrence with antioxidants in food.Thus,this study focused on enlightening the impact of N-acetyl cysteine(NAC),as a representative antioxidative SH-donor,on the mentioned toxicological endpoints of the signature Alternaria toxins alternariol(AOH),altertoxin-II(ATX-II)and a complex extract(CE)of an Alternaria alternata culture.Using Ishikawa cells as an in vitro model,we monitored alterations in toxin concentrations by LC-MS/MS,estrogenicity by alkaline phosphatase assays,cytotoxicity by sulforhodamine B assays,genotoxicity by single-cell gel electrophoresis and the transcription of selected genes of interest by quantitative realtime PCR.The results indicate that the strong genotoxic effects of epoxide-carrying perylene quinones such as ATX-II are erased in the presence of NAC.The cellular effects of ATX-II/AOH mixtures are dominated by the genotoxicity of the perylene chinone.In this mixture,AOH regained its estrogenicity when coincubated with NAC.In contrast,NAC treatment of an AOH/CE mixture did not result in a recovery of estrogenicity,but in potentiated anti-estrogenic effects.These findings were in line with gene transcription data,that indicated the aryl hydrocarbon receptor(AhR)to be a prime mediator of Alternaria toxin e induced antagonistic effects towards estrogen receptor signaling.Taken together,further studies on potential endocrine-disruptive properties of non-genotoxic perylene quinones should be a future research priority in the field of these emerging contaminants. | Georg Aichinger Dino Grgic Julia Beisl Francesco Crudo Benedikt Warth Elisabeth Varga Doris Marko | 2022 | Emerging Contaminants2022，8，1： | 0 |
| 17 | Model Based Study of Thermally Coupled Distillation Sequences for the Separation of Multicomponent Mixtures显示文摘 | VARGAS Maria A LUO Xing FIEG Georg | 2010 | 华东理工大学学报(自然科学版)2010，36，2： | 0 |
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