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| 1 | Adipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways显示文摘Objective:Obesity is closely associated with metastasis in breast cancer patients.Secreted frizzled-related protein 5(SFRP5),one of the novel adipokines with anti-inflammatory properties,is associated with obesity.This study aims to study the role of SFRP5 in the crosstalk between obesity and breast cancer metastasis and identify the underlying mechanism.Methods:3T3-L1 pre-adipocytes were differentiated to mature adipocytes and a hypertrophic adipocyte model was induced with palmitic acid(PA).Cell motility was measured in MDA-MB-231 and MCF-7 breast cancer cells co-cultured with adipocytes conditioned medium(CM)with or without SFRP5 protein.Wnt and epithelialmesenchymal transition(EMT)signal pathways were investigated by western blot.Circulating SFRP5 level in 218 breast cancer patients and the association with clinicopathologic characteristics of breast cancer were further determined.Online databases ENCORI and PREDICT Plus were used to exam the link between SFRP5 and prognosis.Results:Reduced SFRP5 level was detected in the hypertrophic adipocyte model.Recombinant SFRP5 protein inhibited MDA-MB-231 and MCF-7 cells invasion and migration induced by PA-treated adipocyte CM,and SFRP5 inhibition by specific antibody reversed the effect of SFRP5.Furthermore,SFRP5 significantly inhibited Wnt and downstream EMT in breast cancer cells.Low circulating SFRP5 level correlated with body mass index(BMI),lymph node(LN)metastasis,TNM stage and high Ki67 expression in breast cancer patients.Increased SFRP5 level was associated with favorable predicted survival.Kaplan-Meier curves showed high SFRP5 level in tumor tissue was associated with better outcome of breast cancer patients.Conclusions:Our findings demonstrated SFRP5 is a vital adipokine that mediates the crosslink between obesity and the metastatic potential of breast cancer.Promotion of SFRP5 expression in the adipose microenvironment may represent a novel approach for preventing breast cancer metastasis. | Wenzhong Zhou Chunmiao Ye Liang Li Liyuan Liu Fei Wang Lixiang Yu Fei Zhou Yujuan Xiang Yongjiu Wang Gengshen Yin Zhongbing Ma Qinye Fu Qiang Zhang Dezong Gao Shuya Huang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 5 |
| 2 | A Teosinte-derived Allele of a MYB Transcription Repressor Confers Multiple Disease Resistance in Maize.显示文摘Natural alleles controlling multiple disease resistances (MDR) are valuable for crop breeding. However, only one MDR gene have been cloned in maize, and molecular mechanisms of MDR are not clear. By map-based cloning, we have cloned a teosinte-derived allele of a resistance gene, Mexicana lesion mimic 1 (ZmMM1), which has a lesion mimic phenotype and confers resistance to northern leaf blight (NLB), gray leaf spot (GLS) and southern corn rust (SCR). Strong MDR conferred by the teosinte allele is linked with the polymorphisms in the 3' untranslated region of the ZmMM1 gene that cause increased accumulation of ZmMM1 protein. ZmMM1 acts as a transcription repressor and negatively regulates transcription of specific target genes including ZmMM1-target gene 3 (ZmMT3), which functions as a negative regulator of plant immunity and associated cell death. The successful isolation of the ZmMM1 resistance gene will help not only in developing broad-spectrum and durable disease resistance but also in understanding the molecular mechanisms underlying MDR. | Hongze Wang Jiabao Hou Pei Ye Long Hu Junshi Huang Zhikang Dai Bao Zhang Sha Dai Jiamin Que Haoxuan Min Gengshen Chen Yanbo Wang Min Jiang Yan Liang Lin Li Xuecai Zhang Zhibing Lai | 2021 | Molecular Plant2021，14，11： | 4 |
| 3 | ADAPTATION IN CONSECUTIVE INTERPRETING显示文摘 | Hu Gengshen | 2006 | Perspectives2006，，1： | 3 |
| 4 | NEIMADIAN-POINT ACUPUNCTURE ANESTHESIA IN ORTHOPEDIC SURGERY OF EXTREMITIES: AN ANALYSIS OF 198 CASES显示文摘Neimadian-point is a newly-found acupointwith a good analgesic effect. 306 orthopedic op-erations on extremities were underNeimadian-point acupuncture anesthesia withgood results. 198 cases with complete clinicalmaterials were selected and analyzed in the pa-per. | Chang Gengshen Li Jinming Wang Fangxuan, Louyang Orthopedic Institute, Luoyang, Henan Province, China | 1992 | World Journal of Acupuncture-Moxibustion1992，2，4： | 2 |
| 5 | Translation as Adaption and Selection显示文摘 | Hu Gengshen | 2003 | Per- spectives: Studies in Translatology2003，，： | 1 |
| 6 | Adaption in Consecutive Interpreting显示文摘 | Hu Gengshen | 2006 | Perspec- tives: Studies in Translatology2006，，： | 1 |
| 7 | Translation as Adaption and Selection显示文摘 | Hu Gengshen | 2003 | Per spectives: Studies in Translatology2003，，4： | 1 |
| 8 | Translation as adaptation and selection显示文摘 | Hu Gengshen | 2003 | Perspectives:Studies in Translatology2003，，4： | 1 |
| 9 | 查看详情显示文摘 | Hu Gengshen Feng Zhaochi Han Difei | | 0，，： | 1 |
| 10 | Highly Selective Gas-phase Synthesis of 1,1-Dichloroethylene from 1,1,2-Trichloroethane over Supported Amine Catalysts显示文摘 | TANG Cen JIN Yanxia WANG Xiaoxia HU Gengshen XIE Guanqun LI Xiaonian LUO Mengfei | 2015 | Chemical Research in Chinese Universities2015，31，5： | 1 |
| 11 | Translation as Adaptation and Selection显示文摘 | Hu Gengshen | | 0，，： | 1 |
| 12 | Translation as Adaptation and Selection显示文摘 | Hu Gengshen | 2003 | Per-spectives:Studies in Translatology2003，，4： | 1 |
| 13 | Translation As Adaptation and Selection显示文摘 | Hu Gengshen | | 0，，： | 1 |
| 14 | Translation as Adaptation and Selection 显示文摘 | Hu Gengshen | 2003 | Studies in Translatology2003，，4： | 1 |
| 15 | Perspectives: Studies in Translatology 显示文摘 | Hu Gengshen | 2003 | (4): 283-2912003，，4： | 1 |
| 16 | Translation as adaptation and selection显示文摘 | Hu Gengshen | | 0，，： | 1 |
| 17 | Translation as Adap- tation and Selection 显示文摘 | Hu Gengshen | 2003 | Perspectives : Studies in Translatology2003，，4： | 1 |
| 18 | CO Oxidation over CuO/Ce 1-x Cu x O 2-δ and Ce 1-x Cu x O 2-δ Catalysts:Synergetic Effects and Kinetic Study显示文摘 | Jia Aiping Hu Gengshen Ge Lian | 2012 | J Catal2012，289，13： | 1 |
| 19 | Translation as Adaptation and Selection显示文摘 | Hu Gengshen | 2003 | Perspectives:Studies in Translatology2003，，4： | 1 |
| 20 | Translation as Adaption and Selection 显示文摘 | ]Hu Gengshen | 2003 | Perspectives : Studies in Translatology2003，，4： | 1 |
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