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| 1 | Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome显示文摘 | J. Matricon M. Meleine A. Gelot T. Piche M. Dapoigny E. Muller D. Ardid | 2012 | Aliment Pharmacol Ther (pt)2012，，11： | 6 |
| 2 | Lactobacillus aeidophilus mod- ulates intestinal pain and induces opioid and cannabinoid receptors 显示文摘 | Rousseaux C Thuru X Gelot A | 2007 | Nat Med2007，13，1： | 1 |
| 3 | Emulsification of oil and water in the presence of finely divided solid and surface-active agents显示文摘 | Gelot A | 1984 | Colloid and Surfaces1984，，12： | 1 |
| 4 | Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors显示文摘 | Rousseaux C Thuru X Gelot A | 2007 | Nat Med2007，13，1： | 1 |
| 5 | Interactive in-volvement of brain derived neurotrophic factor, nerve growthfactor, and calcitonin gene related peptide in colonic hypersen-sitivity in the rat显示文摘 | DELAFOY L GELOT A ARDID D | 2006 | Gut2006，55，7： | 1 |
| 6 | Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors 显示文摘 | Rousseaux C Thuru X Gelot A | 2007 | Nat Med2007，13，1： | 1 |
| 7 | Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation显示文摘BACKGROUND Chronic abdominal pain is the most common cause for gastroenterology consultation and is frequently associated with functional gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease. These disorders present similar brain/gut/microbiota trialogue alterations, associated with abnormal intestinal permeability, intestinal dysbiosis and colonic hypersensitivity(CHS). Intestinal dysbiosis can alter colon homeostasis leading to abnormal activation of the innate immunity that promotes CHS, perhaps involving the toll-like receptors(TLRs), which play a central role in innate immunity.AIM To understand the mechanisms between early life event paradigm on intestinal permeability, fecal microbiota composition and CHS development in mice with TLRs expression in colonocytes.METHODS Maternal separation model(NMS) CHS model, which mimics deleterious events in childhood that can induce a wide range of chronic disorders during adulthood were used. Colonic sensitivity of NMS mice was evaluated by colorectal distension(CRD) coupled with intracolonic pressure variation(IPV) measurement. Fecal microbiota composition was analyzed by 16S rRNA sequencing from weaning to CRD periods. TLR mRNA expression was evaluated in colonocytes.Additionally, the effect of acute intrarectal instillation of the TLR5 agonist flagellin(FliC) on CHS in adult naive wildtype mice was analyzed.RESULTS Around 50% of NMS mice exhibited increased intestinal permeability and CHS associated with intestinal dysbiosis, characterized by a significant decrease of species richness, an alteration of the core fecal microbiota and a specific increased relative abundance of flagellated bacteria. Only TLR5mRNA expression was increased in colonocytes of NMS mice with CHS. Acute intrarectal instillation of FliC induced transient increase of IPV, reflecting transient CHS appearance.CONCLUSION Altogether, these data suggest a pathophysiological continuum between intestinal dysbiosis and CHS, with a role for TLR5. | Geoffroy Mallaret Amandine Lashermes Mathieu Meleine Ludivine Boudieu Julie Barbier Youssef Aissouni Agathe Gelot Benoit Chassaing Andrew T Gewirtz Denis Ardid Frederic Antonio Carvalho | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 8 | Interactive involvement of brain derived neurotrophic factor,nerve growth factor,and calcitonin gene related peptide in colonic hypersensitivity in the rat显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 9 | Review article:Associations between immune activation,intestinal permeability and the irritable bowel syndrome显示文摘 | Matricon J Meleine M Gelot A | 2012 | Aliment Pharmacol Ther2012，36，1112： | 1 |
| 10 | Lactobacillus acidophi- lus modulates intestinal pain and induces opioid and cannabinoid receptors显示文摘 | Rousseaux C Thuru X Gelot A | 2007 | Nat Med2007，13，1： | 1 |
| 11 | Interactive involvement of brain derived neurotrophic factor, nerve growthfactor, and calcitonin gene related peptide in colonic hypersensitivity in the rat 显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 12 | Interactive involvement of brain derived neurotrophic factor, nerve growth factor,and calcitonin gene related peptide in colonic hypersensitivity in the rat 显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 13 | Interactive involvement of brain de- rived neurotrophic factor,nerve growth factor,and calcitonin gene relat- ed peptide in colonic hypersensitivity in the rat显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 14 | Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat 显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 15 | Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and caici- tonin gene related peptide in colonic hypersensitivity in the rat 显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
| 16 | T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome显示文摘 | MARGER F GELOT A ALLOUI A | 2011 | Proc Natl Acad Sci USA2011，108，11： | 1 |
| 17 | Gaucher disease显示文摘 | Mignot C Gelot A De Villemeur TB | 2013 | Handb Clin Neurol2013，113，： | 1 |
| 18 | Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors显示文摘 | Rousseaux C Thuru X Gelot A | 2007 | Nat Med2007，13，1： | 1 |
| 19 | Prenatal uhrasonographic diagnosis of polymicrogyria 显示文摘 | Dhombres F Nahama-Altouche C Gelot A | 2008 | Ultrasound Obstet Gynecol2008，32，7： | 1 |
| 20 | Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensi- tivity in the rat显示文摘 | Delafoy L Gelot A Ardid D | 2006 | Gut2006，55，7： | 1 |
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