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| 1 | Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia显示文摘AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) screening.METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.RESULTS: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) respectively.CONCLUSION: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. | Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen Geir Hoff Tomm Bernklev Anette Hjartaker Paula Berstad | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 2 | Psychological effects of colorectal cancer screening: Participants vs individuals not invited显示文摘AIM To investigate the possible long-term psychological harm of participating in colorectal cancer(CRC)screening in Norway.METHODS In a prospective, randomized trial, 14294 participants(aged 50-74 years) were invited to either flexible sigmoidoscopy(FS) screening, or a faecal immunochemical test(FIT)(1:1). In total, 4422 screening participants(32%) completed the questionnaire, which consisted of the Hospital Anxiety and Depression Scale and the SF-12, a generic health-related quality of life(HRQOL) measurement, when invited to screening and one year after the invitation. A control group of 7650 individuals was invited to complete the questionnaire only, at baseline and one year after, and 1911(25%) completed the questionnaires.RESULTS Receiving a positive or negative screening result and participating in the two different screening modalities did not cause clinically relevant mean changes in anxiety, depression or HRQOL after one year. FS screening, but not FIT, was associated with an increased probability of being an anxiety case(score ≥ 8) at the one-year follow-up(5.6% of FS participants transitioned from being not anxious to anxious, while 3.0% experienced the reverse). This increase was moderately significantly different from the changes in the control group(in which the corresponding numbers were 4.8% and 4.5%, respectively), P = 0.06. CONCLUSION Most individuals do not experience psychological effects of CRC screening participation after one year, while FS participation is associated with increased anxiety for a smaller group. | Benedicte Kirk?en Paula Berstad Edoardo Botteri Linn Bernklev Badboni El-Safadi Geir Hoff Thomas de Lange Tomm Bernklev | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 3 | Improvement in caecal intubation rate and pain reduction by using 3-dimensional magnetic imaging for unsedated colonoscopy: A randomized trial of patients referred for colonoscopy显示文摘 | Geir Hoff Michael Bretthauer Stein Dahler Gert Huppertz-Hauss Jostein Sauar J?rn Paulsen Birgitte Seip Volker Moritz | 2007 | Scandinavian Journal of Gastroenterology2007，，7： | 1 |
| 4 | Different standards for healthy screenees than patients in routine clinics?显示文摘Less than 5%of colorectal adenomas will become malignant,but we do not have sufficient knowledge about their natural course to target removal of these5%only.Thus,95%of polypectomies are a waste of time exposing patients to a small risk of complications.Recently,a new type of polyps,sessile serrated polyps,has attracted attention.Previously considered innocuous,they are now found to have molecular similarities to cancer and some guidelines recommend to have them removed.These lesions are often flat,covered by mucous,not easily seen and situated in the proximal colon where the bowel wall is thinner.Thus,polypectomy carries a higher risk of perforation than predominantly left-sided,stalked adenomas-and we do not know what is gained in terms of cancer prevention.Screening is a neat balance between harms and benefit for presumptively healthy participants not interested in risk exposure to obtain confirmation of being healthy.The situation is quite different for patient worried about symptom.Thus,the standards set for evidence-based practice may be higher for screening than for routine clinics-a mechanism which may benefit patients in the long run. | Geir Hoff | 2013 | World Journal of Gastroenterology2013，19，46： | 1 |
| 5 | The Norwegian Gastronet project: Continuous quality improvement of colonoscopy in 14 Norwegian centres显示文摘 | Geir Hoff Michael Bretthauer Gert Huppertz-Hauss Eirik Kittang Asbj?rn Stallemo Ole H?ie Stein Dahler Sverre Nyhus Fred-Arne Halvorsen Jens Pallenschat K?re Vetvik Per Kristian Sandvei Joachim Friestad Reidar Pytte Peter Coll | 2006 | Scandinavian Journal of Gastroenterology2006，，4： | 1 |
| 6 | Magnetic endoscopic imaging versus standard colonoscopy in a routine colonoscopy setting: a randomized, controlled trial显示文摘 | ?yvind Holme Ole H?ie Jon Matre Asbj?rn Stallemo Kjetil Garborg Audun Hasund Haavard Wiig Geir Hoff Michael Bretthauer | 2011 | Gastrointestinal Endoscopy2011，，6： | 1 |
| 7 | Improvement in caecal intubation rate and pain reduction by using 3-dimensional magnetic imaging for unsedated colonoscopy: A randomized trial of patients referred for colonoscopy显示文摘 | Geir Hoff Michael Bretthauer Stein Dahler Gert Huppertz-Hauss Jostein Sauar J?rn Paulsen Birgitte Seip Volker Moritz | 2007 | Scandinavian Journal of Gastroenterology2007，，7： | 1 |
| 8 | 癌症筛检项目效果比较研究显示文摘癌症大规模筛检项目在获得新证据或对新证据作出应答方面,往往经不起考验。为了克服筛检项目的这些缺点,本文作者根据筛检效果的比较研究概述了在挪威实施的一种新的筛检方法? | Michael Bretthauer Geir Hoff 许群(译) 乌正赉(校) | 2012 | 英国医学杂志中文版2012，15，5： | 0 |
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