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| 1 | Diagnosis of clinical and subclinical varicocele: how has it evolved?显示文摘在这评论,我们为在一个精索静脉曲张病人的评估以 venography, scintigraphy,和 thermography 和他们的角色开始的精索静脉曲张检验各种各样的诊断形式的进化和申请。一些这些方法被不太侵略、更容易执行的诊断形式,特别超声和阴囊的 Doppler 检查取代了。在超声和磁性的回声成像的进展保持潜力在精索静脉曲张的视觉证实和描述的以外扩展成像的角色。基于成像调查结果识别阴囊的机能障碍的早指示物的能力以后可以为精索静脉曲张的管理有含意。 | Ruth E Belay Gene Omar Huang Jim Ken-Chie Shen Edmund Yuey Kun Ko | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Neurocognitive Performance in Hypertensive Patients after Spine Surgery显示文摘 | Gene T. Yocum John G. Gaudet Lauren A. Teverbaugh Donald O. Quest Paul C. McCormick E Sander Connolly Eric J. Heyer | 2009 | Anesthesiology2009，，2： | 2 |
| 4 | Erythropoietin downreg- ulates bax and DP5 pro-apoptotie gene expression in neo- natal hypoxie-isehemie brainInjury 显示文摘 | Kumral A Gene S Ozer E | 2005 | Biol Neonate2005，89，3： | 1 |
| 5 | What is the best strategy for diagosis and treatment of Helicobacter pylori in the prevention of recurrent peptic ulcer bleeding?A cost-effectiveness analysis显示文摘 | Gene E Sanchez-Delgado J Calvet X | 2009 | Value Health2009，12，5： | 1 |
| 6 | coli cytoplasm 显示文摘 | LAVALLIE ER DIBLASIO EA KOVACIC S l A thioredoxin gene fusion expression system that circumvents inclusion body formation in the E | 1993 | Biotechn ology1993，11，2： | 1 |
| 7 | Pneumococcal serotypes causing acute otitis media among children in Barcelona (1992-2011):emergence of the multiresistant clone ST320 of serotype 19A显示文摘 | Gene A del Amo E I(n)igo M | | 0，，04： | 1 |
| 8 | 显示文摘 | Rahman M McVetty P B E,Li G Y,Development of SRAP1SNP and multiplexed SCAR molecular markers for the major seed coat color gene in Brassica rapa L | 2007 | Theoretical and Applied Genetics2007，115，8： | 1 |
| 9 | Suitability of the YNZ22 (D17S5) VNTR polymorphismfor legal medicine investigations in the population of Catalonia(Spain)显示文摘 | Gene M Huguet E Sanchez Garcia C | 1995 | Int J Leagel Med1995，107，4： | 1 |
| 10 | Cadmium toxicity among wildlife in the Colorado Rocky Mountaion显示文摘 | James R L Gene E L John W F | | 0，，13： | 1 |
| 11 | a Primer for Neurosurgeons显示文摘 | Chiocca E A Gene Therapy | 2003 | Neurosurgery2003，53，2： | 1 |
| 12 | Starvation proteins in Escherichia coli:Kinetics of synthesis and role in starvation survival, 显示文摘 | Gene GR Schuhz JE Zychlinsky E | 1986 | J Bacteriol1986，168，2： | 1 |
| 13 | Agro-forestry practice and policy in the United States of America显示文摘 | H E Gene Garrett Louise Buck | 1997 | Forest Ecology and Management1997，91，1： | 1 |
| 14 | Embrologic and anatomic basis of inguinal herniorrhaphy显示文摘 | John E skandalakis Gene L | 1993 | Sury clin North Am1993，73，4： | 1 |
| 15 | erring显示文摘 | DE ROSSI E BRANZONI M CANTONI mmr a Mycobacterium tuberculosis gene resistance to small cationic dyes and inhibit | 1998 | JBacteriol1998，180，： | 1 |
| 16 | a Study of Teachers’Concerns About an Innovation:Its Concept,Assessing Technique,And Implications显示文摘 | See Gene E Hall Wen-haur Shieh | 1998 | 花莲师院学报(台湾)1998，，8： | 1 |
| 17 | Erythropoietin downregu-lates bax and DP5 proapoptotic gene expression in neonatalhypoxic- ischemic brain injury 显示文摘 | Kumral A Gene S Ozer E | 2006 | Biol Neonate t2006，89，3： | 1 |
| 18 | coli显示文摘 | Transposition of Pseudomonas toluene-degrading genes and expression in E | 1978 | Nature1978，274，： | 1 |
| 19 | Erythropoietin downregulates Bax and DP5 pro-apoptotic gene expression in neonatal hypoxic-ischemic brain injury 显示文摘 | Kumral A Gene S Ozer E | 2005 | Biol Neonate2005，89，3： | 1 |
| 20 | Simple Partitioning of Anions and Dissolved Organic Carbon in A Forest Soil显示文摘 | NODVIN STEPHEN C DRISCOLL CHARLES T LIKENS GENE E | 1986 | Soil Science1986，142，1： | 1 |
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