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| 1 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 2 | Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials. | Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves Pierre Cordelier Louis Buscail | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 3 | Laparoscopic pericys - tectomy of a liver hydatid cyst 显示文摘 | Guibert L Gayral F | 1995 | Surg Endosc1995，9，： | 1 |
| 4 | INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse 显示文摘 | Jacoby M Cox JJ Gayral S | 2009 | Nat Genet2009，41，9： | 1 |
| 5 | INPPSE mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse显示文摘 | Jacoby M Cox JJ Gayral S | 2009 | Nat Genet2009，41，9： | 1 |
| 6 | Targeting miR-21 for the therapy of pancreatic cancer显示文摘 | Sicard F Gayral M Lulka H | 2013 | Mol Ther2013，21，5： | 1 |
| 7 | Single banana streak virus integration event in the banana genome as the origin of infectious endogenous pararetrovirus显示文摘 | Gayral P Noa-Carrazana J C Lescot M | 2008 | Journal of Virology2008，82，13： | 1 |
| 8 | Molluscicides in schisto- somiasis control 显示文摘 | McCullough FS Gayral P Duncan J | 1980 | Bull World Health Organ1980，58，5： | 1 |
| 9 | Genetic and pharmacological targeting of phosphoinositide 3-kinase-3, reduces atherosclerosis and favors plaque stability by modulating inflammatory processes 显示文摘 | Fougerat A Gayral S Gourdy P | 2008 | Circulation2008，117，10： | 1 |
| 10 | Phosphoinositide 3-kinases and their role in inflammation:potential clinical targets in atherosclerosis?显示文摘 | Fougerat A Gayral S Malet N | 2009 | Clin Sci (Lond)2009，116，11： | 1 |
| 11 | Targeting miR-21 for the Ther- apy of Pancreatic Cancer显示文摘 | Sicard F Gayral M Lulka H | 2013 | Mol Ther2013，21，5： | 1 |
| 12 | Phosphoinositide 3-kinases and their role in inflammation:potential clinical targets in atherosclerosis显示文摘 | Fougerat A Gayral S Malet N | | 0，，11： | 1 |
| 13 | InAs quantum dots:artificial atoms for solidstate cavity-quantum electrodynamics显示文摘 | Gerard J M Gayral B | | 0，，01： | 1 |
| 14 | Value of celioscopy in the diagnosis of abdominal wounds显示文摘 | De Watteville J C Molinier N Gayral F | 1995 | Ann Chir1995，49，7： | 1 |
| 15 | High-Q wet-etched GaAs microdisks containing InAs quantum boxes显示文摘 | Gayral B Gerard J M Lemaitre A | 1999 | Applied Physics Letters1999，75，： | 1 |
| 16 | Targeting PI3Kgamma activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response显示文摘 | Smirnova NF Gayral S Pedros C | 2014 | J Exp Med2014，211，： | 1 |
| 17 | Targeting mi R-21 for the therapy of pancreatic cancer显示文摘 | Sicard F Gayral M Lulka H | 2013 | Mol Ther2013，21，5： | 1 |
| 18 | Molluscicides in schistosomiasis control显示文摘 | McCullough FS Gayral P Duncan J et ol | 1980 | Bull World Health Organ1980，58，5： | 1 |
| 19 | A single banana streak virus integration event in the banana genome as the ori gin of infectious endogenous pararetrovirus 显示文摘 | Gayral P Carrazana J N Lescot M | 2008 | Journal of Virology2008，7，： | 1 |
| 20 | Reference - free population genomics from next - generation transcriptome data and the vertebrate - invertebrate gap 显示文摘 | Gayral P Melo - Ferreira J Glgmin S | 2013 | PLoS Genetics2013，9，10： | 1 |
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