4篇
您的检索式：作者名="Gaurisankar"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts显示文摘Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion.CD81 cytotoxic T lymphocytes(CTLs)are involved in antigen-specific tumor destruction and CD41 T cells are essential for helping this CD81 T cell-dependent tumor eradication.Tumors often target and inhibit T-cell function to escape from immune surveillance.This dysfunction includes loss of effector and memory T cells,bias towards type 2 cytokines and expansion of T regulatory(Treg)cells.Curcumin has previously been shown to have antitumor activity and some research has addressed the immunoprotective potential of this plant-derived polyphenol in tumor-bearing hosts.Here we examined the role of curcumin in the prevention of tumor-induced dysfunction of T cell-based immune responses.We observed severe loss of both effector and memory T-cell populations,downregulation of type 1 and upregulation of type 2 immune responses and decreased proliferation of effector T cells in the presence of tumors.Curcumin,in turn,prevented this loss of T cells,expanded central memory T cell(TCM)/effector memory T cell(TEM)populations,reversed the type 2 immune bias and attenuated the tumor-induced inhibition of T-cell proliferation in tumor-bearing hosts.Further investigation revealed that tumor burden upregulated Treg cell populations and stimulated the production of the immunosuppressive cytokines transforming growth factor(TGF)-b and IL-10 in these cells.Curcumin,however,inhibited the suppressive activity of Treg cells by downregulating the production of TGF-b and IL-10 in these cells.More importantly,curcumin treatment enhanced the ability of effector T cells to kill cancer cells.Overall,our observations suggest that the unique properties of curcumin may be exploited for successful attenuation of tumor-induced suppression of cell-mediated immune responses. | Sankar Bhattacharyya Dewan Md Sakib Hossain Suchismita Mohanty Gouri Sankar Sen Sreya Chattopadhyay Shuvomoy Banerjee Juni Chakraborty Kaushik Das Diptendra Sarkar Tanya Das Gaurisankar Sa | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 2 | Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction显示文摘 | Tathagata Choudhuri Suman Pal Munna L Agwarwal Tanya Das Gaurisankar Sa | 2002 | FEBS Letters2002，，1： | 1 |
| 3 | GM1 and tumor necrosis factor-, overexpressed in renal cell carcinoma, synergize to induce T-cell apoptosis 显示文摘 | TANYA D GAURISANKAR S CYNTHIA H | 2008 | Cancer Research2008，68，6： | 1 |
| 4 | Protein A-in Juced apoptosis of cancer cells is effected by soluble immune mediators 显示文摘 | Tanya D Gaurisankar S Sreya C | 2002 | Cancer Immunology Immuno- therapy2002，51，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员