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| 1 | Prevalence of Helicobacter pylori infection and intestinal metaplasia in subjects who had undergone surgery for gastric adenocarcinoma in Northwest Italy显示文摘AIM: To investigate the seroprevalence of Helicobacter pylori(H pylorri) infection and its more virulent strains as well as the correlation with the histologic features among patients who had undergone surgery for gastric cancer (GC).METHODS: Samples from 317 (184 males, 133females, mean age 69±3.4 years) consecutive patients who had undergone surgery for gastric non-cardia adenocarcinoma were included in the study. Five hundred and fifty-five (294 males, 261 females, mean age 57.3±4.1 years) patients consecutively admitted to the Emergency Care Unit served as control. Histological examination of tumor, lymph nodes and other tissues obtained at the time of surgery represented the diagnostic 'gold standard'. An enzyme immunosorbent assay was used to detect serum anti-H pylori(IgG)antibodies and Western blotting technique was utilized to search for anti-CagA protein (IgG).RESULTS: Two hundred and sixty-one of three hundred and seventeen (82.3%) GC patients and 314/555 (56.5%)controls were seropositive for anti-H pylori (P<0.0001;OR, 3.58; 95%CI, 2.53-5.07). Out of the 317 cases, 267(84.2%) were seropositive for anti-CagA antibody vs 100 out of 555 (18%) controls (P<0.0001; OR, 24.30;95%CI, 16.5-35.9). There was no difference between the frequency of H pyloriin intestinal type carcinoma (76.2%) and diffuse type cancer (78.8%). Intestinal metaplasia (IM) was more frequent but not significant in the intestinal type cancer (83.4% vs 75.2% in diffuse type and 72.5% in mixed type). Among the patients examined for IM, 39.8% had IM type Ⅰ, 8.3% type Ⅱ and 51.9% type Ⅲ (type Ⅲ vs others, P = 0.4).CONCLUSION; This study confirms a high seroprevalence of H pyloriinfection in patients suffering from gastric adenocarcinoma and provides further evidence that searching for CagA status over H pylori infection might confer additional benefit in identifying populations at greater risk for this tumor. | Giorgio Palestro Rinaldo Pellicano Gian Ruggero Fronda Guido Valente Marco De Giuli Tito Soldati Agostino Pugliese Stefano Taraglio Mauro Garino Donata Campra Miguel Angel Cutufia Elena Margaria Giancarlo Spinzi Aldo Ferrara Giorgio Marenco Mario Rizzetto Antonio Ponzetto | 2005 | World Journal of Gastroenterology2005，11，45： | 5 |
| 2 | 现代氧化铝陶瓷应用于全髋关节置换术的可靠性显示文摘全髋关节置换术中,陶瓷部件失效是一种十分罕见而严重的并发症。随着陶瓷材料质量、制作工艺及假体设计方面的改进,陶瓷部件失效的发生率正稳定地下降。自2000年1月至2006年5月, CeramTec公司生产的BIOLOX品牌陶瓷部件失效的发生率约为0.02%,即一万例中有2例发生。目前全髋关节置换术中陶瓷部件发生失效的风险估计为万分之二,其中大多发生于陶瓷球头。因此,氧化铝陶瓷在现代全髋关节置换术中的应用安全可靠,且具有极低的失效风险。 | Jonathan Garino Mohamed N.Rahaman B.Sonny Bal 沈彬 | 2009 | 国际骨科学杂志2009，30，2： | 4 |
| 3 | Morbidity and mortality after D1 and D2 gastrectomy for cancer: Interim analysis of the Italian Gastric Cancer Study Group (IGCSG) randomised surgical trial显示文摘 | M Degiuli M Sasako M Calgaro M Garino F Rebecchi M Mineccia D Scaglione D Andreone A Ponti F Calvo | 2004 | European Journal of Surgical Oncology2004，，3： | 2 |
| 4 | Low tfiiodothyronine serum levels as a predictor of poor prognosis in bum patients 显示文摘 | Gangemi EN Garino F Berehialla P | 2008 | Burns2008，34，6： | 1 |
| 5 | Total hip arthroplasty in patient with avascular necrosis of the femoral head显示文摘 | Garino JP Steinberg ME | 1997 | Clin Orthop1997，334，1： | 1 |
| 6 | Determining lesion size in osteoneerosis of the femoral head 显示文摘 | Steinberg DR Steinberg ME Garino JP | 2006 | J Bone Joint Surg Am2006，88，3： | 1 |
| 7 | Get the right mix of bricks and clicks显示文摘 | Gulati R Garino J | 2001 | Harvard Business Review2001，78，3： | 1 |
| 8 | Regulation of BMP-induced transcription in cultured human bone marrow stromal cel s显示文摘 | Diefenderfer DL Osyczka AM Garino JP | | 0，，3： | 1 |
| 9 | Active chemotherapy for sarcomatoid and rapidly progressing renal cell carcinoma显示文摘 | NANUS DM GARINO A MILOWSKY MI | 2004 | Cancer2004，101，7： | 1 |
| 10 | The mechanical properties,dimensional tolerance and microstructural characterization of micro-molded ceramic and metal components显示文摘 | GARINO T J MORALES A M BOYCE B L | 2004 | Microsystem Technologies2004，，10： | 1 |
| 11 | A review of ceramic bearing materials in total joint arthroplasty显示文摘 | Bal BS Garino J Ries M | | 0，，01： | 1 |
| 12 | Autologous blood reinfusion in patients undergoing bilateral total hip arthroplasty显示文摘 | Gee A O Garino J P Lee G C | 2011 | J Orthop Surg(Hong Kong)2011，19，2： | 1 |
| 13 | Long term followup of thorough debridement and cancellous bone grafting of the femoral head for avascular necrosis显示文摘 | Garino JP Kiernan HA | 1994 | Clin orthop1994，306，： | 1 |
| 14 | Computer-aided interactive indirect bonding显示文摘 | Garino F Garino GB | 2005 | Prog Orthod2005，6，2： | 1 |
| 15 | Determining lesion size in osteonecrosis of femoral head显示文摘 | Steinberg DR Steinberg ME Garino JP | | 0，，01： | 1 |
| 16 | Long term followup of thorough debridement and cancellous bone grafting of the femoral head for avascular necrosis显示文摘 | Rosenwasser MP Garino JP Kieman HA | 1994 | Clin Orthop Relat Res1994，，306： | 1 |
| 17 | Long term follow-up of thorough debridement and cancellous bone grafting of the femoral head for avascular necrosis显示文摘 | Rosenwasser MP Garino JP Kiernan HA | 1994 | Clin Orthop1994，306，： | 1 |
| 18 | Active chemotherapy for sarcomatoid and progressing renal cell carcinoma 显示文摘 | NANUS D M GARINO A MILOWSKY M I | 2004 | Cancer2004，101，7： | 1 |
| 19 | Seven-year results of a tapered, titanium, hydroxyapatite-coated cementless femoral stem in primary total hip arthroplasty 显示文摘 | Cho JH Garino JP Choo SK | 2010 | Clin Orthop Surg2010，2，4： | 1 |
| 20 | Naphthyl and coumaxinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors: Design, synthe- sis, and enzymatic BACE-1 and cell assays 显示文摘 | Garino C Tomita T Pietrancosta N | 2006 | J Med Chem2006，49，14： | 1 |
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