|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 2 | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?显示文摘Diabetes mellitus(DM) that occurs because of chronic liver disease(CLD) is known as hepatogenous diabetes(HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus(HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease. | Diego García-Compeán José Alberto González-González Fernando Javier Lavalle-González Emmanuel Irineo González-Moreno Jesús Zacarías Villarreal-Pérez Héctor Jesús Maldonado-Garza | 2016 | World Journal of Gastroenterology2016，22，10： | 12 |
| 3 | Mitochondrial protection by low doses of insulin-like growth factor-Ⅰin experimental cirrhosis显示文摘AIM: To characterize the mitochondrial dysfunction in experimental cirrhosis and to study whether insulin-like growth factor-Ⅰ(IGF-Ⅰ) therapy (4 wk) is able to induce beneficial effects on damaged mitochondria leading to cellular protection. METHODS: Wistar rats were divided into three groups: Control group, untreated cirrhotic rats and cirrhotic rats treated with IGF-Ⅰtreatment (2 μg/100 g bw/d). Mitochondrial function was analyzed by flow cytometry in isolated hepatic mitochondria, caspase 3 activation was assessed by Western blot and apoptosis by TUNEL in the three experimental groups. RESULTS: Untreated cirrhotic rats showed a mitochon- drial dysfunction characterized by a significant reduction of mitochondrial membrane potential (in status 4 and 3); an increase of intramitochondrial reactive oxigen species (ROS) generation and a significant reduction of ATPase activity. IGF-Ⅰtherapy normalized mitochondrial func-tion by increasing the membrane potential and ATPase activity and reducing the intramitochondrial free radical production. Activity of the electron transport complexes Ⅰand Ⅲ was increased in both cirrhotic groups. In addition, untreated cirrhotic rats showed an increase of caspase 3 activation and apoptosis. IGF-Ⅰtherapy reduced the expression of the active peptide of caspase 3 and resulted in reduced apoptosis. | Raquel Pérez María García-Fernández Matías Díaz-Sánchez Juan E Puche Gloria Delgado Marian Conchillo Jordi Muntané Inma Castilla-Cortázar | 2008 | World Journal of Gastroenterology2008，14，17： | 11 |
| 4 | Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multicenter phase I/IIa clinical trial显示文摘 | F. Portilla F. Alba D. García-Olmo J. M. Herrerías F. X. González A. Galindo | 2013 | International Journal of Colorectal Disease2013，，3： | 5 |
| 5 | Clinical implications of diabetes in chronic liver disease:Diagnosis,outcomes and management,current and future perspectives显示文摘Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects of the association DM and LC has been intensified.Nevertheless,it has been insufficient and still exist many gaps.The aims of this review are:(1)To discuss the latest understandings of the association of DM and LC in order to identify the strategies of early diagnosis;(2)To evaluate the impact of DM on outcomes of LC patients;and(3)To select the most adequate management benefiting the two conditions.Literature searches were conducted using Pub Med,Ovid and Scopus engines for DM and LC,diagnosis,outcomes and management.The authors also provided insight from their own published experience.Based on the published studies,two types of DM associated with LC have emerged:Type 2 DM(T2 DM)and hepatogenous diabetes(HD).High-quality evidences have determined that T2 DM or HD significantly increase complications and death pre and post-liver transplantation.HD has been poorly studied and has not been recognized as a complication of LC.The management of DM in LC patients continues to be difficult and should be based on drug pharmacokinetics and the degree of liver failure.In conclusion,the clinical impact of DM in outcomes of LC patients has been the most studied item recently.Nevertheless many gaps still exist particularly in the management.These most important gaps were highlighted in order to propose future lines for research. | Diego García-Compeán Emanuela Orsi Ramesh Kumar Felix Gundling Tsutomu Nishida Jesús Zacarías Villarreal-Pérez Ángel N Del Cueto-Aguilera JoséA González-González Giuseppe Pugliese | 2022 | World Journal of Gastroenterology2022，28，8： | 4 |
| 6 | Robotic transanal total mesorectal excision:Is the future now?显示文摘Total mesorectal excision(TME)is the standard surgical treatment for the curative radical resection of rectal cancers.Minimally invasive TME has been gaining ground favored by the continuous technological advancements.New procedures,such as transanal TME(TaTME),have been introduced to overcome some technical limitations,especially in low rectal tumors,obese patients,and/or narrow pelvis.The earliest TaTME reports showed promising results when compared with the conventional laparoscopic TME.However,recent publications raised concerns regarding the high rates of anastomotic leaks or local recurrences observed in national series.Robotic TaTME(R-TaTME)has been proposed as a novel technique incorporating the potential benefits of a perineal dissection together with precise control of the distal margins,and also offers all those advantages provided by the robotic technology in terms of improved precision and dexterity.Encouraging short-term results have been reported for R-TaTME,but further studies are needed to assess the real role of the new technique in the long-term oncological or functional outcomes.The present review aims to provide a general overview of R-TaTME by analyzing the body of the available literature,with a special focus on the potential benefits,harms,and future perspectives for this novel approach. | Juan Carlos Sebastián-Tomás Aleix Martínez-Pérez Elías Martínez-López Nicola de'Angelis Marcos Gómez Ruiz Eduardo García-Granero | 2021 | World Journal of Gastrointestinal Surgery2021，13，8： | 2 |
| 7 | Measurement planning for circular cross-section tunnels using terrestrial laser scanning显示文摘 | Ramón Argüelles-Fraga Celestino Ordó?ez Silverio García-Cortés Javier Roca-Pardi?as | 2013 | Automation in Construction2013，，： | 2 |
| 8 | Extraction and determination of ellagic acid contentin chestnut bark and fruit显示文摘 | S.A. Vekiari M.H. Gordon P. García-Macías H. Labrinea | 2008 | Food Chemistry2008，，4： | 2 |
| 9 | The role of direct high-resolution mass spectrometry in foodomics显示文摘 | IBá?EZ C SIMó C GARCíA-CA?AS V | 2015 | Analytical and Bioanalytical Chemistry2015，407，21： | 1 |
| 10 | Acute transplantation of olfactory ensheathing cells or Schwann cells promotes recovery after spinal cord injury in the rat显示文摘 | García-Aliías G Lpez-Vales R Forés J | 2004 | J Neurosci Res2004，75，5： | 1 |
| 11 | New molecular targets for the treatment of osteoarthritis显示文摘 | Alcaraz MJ Meg i as J Garc i a-Arnandis I | 2010 | Biochem Pharmacol2010，80，1： | 1 |
| 12 | Vascularized free fibular flap for the reconstruction of mandibular defects:clinical experience in 42 cases显示文摘 | García RG Gías NL Francisco JRC | 2008 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2008，106，2： | 1 |
| 13 | Hyperhomocysteinemia in Liver Cirrhosis: Mechanisms and Role in Vascular and Hepatic Fibrosis显示文摘 | Elena Ruiz García-Tevijano Carmen Berasain José Antonio Rodríguez Fernando José Corrales Roberto Arias Antonio Martín-Duce Juan Caballería José María Mato Matías Antonio Avila | 2001 | Hypertension: Journal of the American Heart Association2001，，5： | 1 |
| 14 | MicroporouspheGnolGformaldehyderesinGbasedadsorbentsforpreGcombustionCO2capture显示文摘 | MartínCF PlazaM G GarcíaS etal | 2011 | Fuel2011，90，5： | 1 |
| 15 | Acute transplantation of olfactory ensheathing cells or Schwann cells promotes recovery after spinal cord injury in the rat显示文摘 | García-Alías G López-Vales R Forés J | 2004 | Neurosci Res2004，75，5： | 1 |
| 16 | Reduced systolic performance by tissue Doppler in patients with preserved and abnormal ejection fraction:New insights in chronic heart failure显示文摘 | Perna ER Farías EF | 2006 | Intern J Cardiol2006，108，： | 1 |
| 17 | Micro‐RNA signature of the epithelial–mesenchymal transition in endometrial carcinosarcoma显示文摘 | María ángelesCastilla GemaMoreno‐Bueno LauraRomero‐Pérez Koen VanDe Vijver MicheleBiscuola María ángelesLópez‐García JaimePrat XavierMatías‐Guiu AmparoCano EstherOliva JoséPalacios | 2010 | J Pathol2010，，1： | 1 |
| 18 | Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis:insights into tuberculosis evolution,phylogenetic accuracy of other DNA fingerprinting systems,and recommendations for a minimal standard SNP set显示文摘 | Filliol I Motiwala AS Cavatore M Qi W Hazbón MH Bobadilla del Valle M Fyfe J García-García L Rastogi N Sola C Zozio T Guerrero MI León CI Crabtree J Angiuoli S Eisenach KD Durmaz R Joloba ML Rendón A Sifuentes-Osornio J Ponce de León A Cave MD Fleischmann R Whittam TS Alland D | 2006 | J Bacteriol2006，188，2： | 1 |
| 19 | Response to McAvoy and Tudor-Locke on their commentary on our manuscript:“Association of accelerometer-derived step volume and intensity with hospitalizations and mortality in older adults:A prospective cohort study”显示文摘Dear Editor,We have read with interest the commentary by McAvoy and Tudor-Locke on our article entitled 'Association of accelerometer-derived step volume and intensity with ho spitalizations and mortality in older adults:A prospective cohort study'. The authors expressed some concerns about our methodology used to define accelerometer-derived step intensity and the analytical approach applied in our study. | Asier Mañas Borja del Pozo Cruz Ulf Ekelund JoséLosa Reyna Irene Rodríguez Gómez JoséAntonio Carnicero Carreño Leocadio Rodríguez Mañas Francisco J.García García Ignacio Ara | 2022 | Journal of Sport and Health Science2022，11，6： | 1 |
| 20 | Diagnostic accuracy of FDG PET in the follow-up of platinum-sensitive epithelial ovarian carcinoma显示文摘 | María José García-Velloso Matías Jurado Carolina Ceamanos José Manuel Aramendía María Puy Garrastachu Guillermo López-García José ángel Richter | 2007 | European Journal of Nuclear Medicine and Molecular Imaging2007，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员