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| 1 | A review on assessment and treatment of the trunk in stroke A need or luxury显示文摘Trunk function has been identified as an important early predictor of functional outcome after stroke and the same deteriorates on both contralateral and ipsilateral sides of the body following stroke.The primary contribution of the trunk muscles is to allow the body to remain upright,adjust weight shifts,and control movements against constant pull of gravity and is considered central key point of the body.Proximal stability of the trunk is a pre-requisite for distal limb mobility,balance,gait and functional activities and its positive correlation in hemiplegia has been demonstrated in a cross-sectional study.Both isokinetic and handheld dynamometer muscle strength testing demonstrated the weakness of bilateral trunk flexors,extensors and rotator muscles in both acute and chronic hemiplegic patients.This was confirmed by electromyography analysis which identified poor bilateral trunk muscles activity in patients with stroke.Trunk impairment scale is sensitive to evaluate the selective muscle control of upper and lower trunk,and it has been reported that lateral flexion of the trunk is easier than rotation of the trunk and the clinical observation concurs to the difficulty in lower trunk rotation of stroke patients.However,trunk exercises given early after stroke could produce enhanced balance performance post-stroke.This review attempts to report the evidence supporting the involvement of the trunk and its influence on balance and functional performance in post-stroke hemiplegia. | Suruliraj Karthikbabu Mahabala Chakrapani Sailakshmi Ganeshan Kedambadi C Rakshith Syed Nafeez Venkatesan Prem | 2012 | Neural Regeneration Research2012，7，25： | 5 |
| 2 | Current update on molecular cytogenetics, diagnosis and management of gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract and are thought to arise from precursors of the interstitial cells of Cajal.GISTs can arise anywhere in the GI tract,but most commonly originate from the stomach and small intestine.The majority of GISTs occur as a result of activating mutations in two receptor protein tyrosine kinases:KIT and/or platelet-derived growth factor receptor-α.Mutational analyses allow for predicting patient prognosis and treatment response.Clinical presentations can vary from no symptoms,typical in the case of small incidentally found tumors,to GI bleeding,abdominal discomfort,and ulcer-related symptoms when the tumor is enlarged.Imaging plays a critical role in the diagnosis and management of these tumors with multiphasic computed tomography serving as the imaging modality of choice.Magnetic resonance imaging and positron emission tomography-computed tomography can serve as imaging adjuncts in lesion characterization,especially with liver metastases,and subsequent staging and assessment for treatment response or recurrence.Surgical resection is the preferred management for small GISTs,while tyrosine kinase inhibitors−imatinib mesylate and sunitinib malate−serve as crucial molecular-targeted therapies for locally advanced and metastatic GISTs.This review article highlights the clinical presentation,pathology and molecular cytogenetics,imaging features,and current management of GISTs. | Mindy X Wang Catherine Devine Nicole Segaran Dhakshinamoorthy Ganeshan | 2021 | World Journal of Gastroenterology2021，27，41： | 5 |
| 3 | Extrahepatic 胆汁的癌症: 新阶段分类显示文摘 Tumor staging defines the point in the natural history of the malignancy when the diagnosis is made. The most common staging system for cancer is the tumor, node, metastases classification. Staging of cancers provides useful parameters in the determination of the extent of disease and prognosis. Cholangiocarcinoma are rare and refers to cancers that arise from the biliary epithelium. These tumors can occur anywhere along the biliary tree. These tumors have been previously divided into extrahepatic and intrahepatic lesions. Until recently the extrahepatic bile duct tumors have been considered as a single entity per American Joint Com- mission on Cancer (AJCC) staging classification. The most recent changes to the AJCC classification of bile duct cancers divide the tumors into two major catego- ries: proximal and distal tumors. This practical classifi- cation is based on anatomy and surgical management. High quality cross-sectional computed tomography (CT) and/or magnetic resonance (MR) imaging of the abdomen are essential information to accurately stage this tumors. Imaging plays an important role in diag-nosis, localization, staging and optimal management of cholangiocarcinoma. For example, it helps to localize the tumor to either perihilar or distal bile duct, both of which have different management. Further, it helps to accurately stage the disease and identify the presence of significant nodal and distant metastasis, which may preclude surgery. Also, it helps to identify the extent of local invasion, which has a major impact on the management. For example, extensive involvement of hepatic duct reaching up to second-order biliary radi- cals or major vascular encasement of portal vein or hepatic arteries precludes curative surgery and patient may be managed by palliative therapy. Further, imag- ing helps to identify any anatomical variations in the hepatic arterial or venous circulation and biliary ductal system, which is vital information for surgical planning. This review presents relevant clinical presentation and imaging acquisition and presentation for the accurate staging classification of bile duct tumors based on the new AJCC criteria. This will be performed with the as- sistance of anatomical diagrams and representative CT and MR images. The image interpretation must include all relevant imaging information for optimum staging. Detailed recommendations on the items required on the radiology report will be presented. | Dhakshinamoorthy Ganeshan Fanny E Moron Janio Szklaruk | 2012 | World Journal of Radiology2012，4，8： | 5 |
| 4 | Virtual colonoscopy: Utility, impact and overview显示文摘Computed tomography (CT) colonoscopy is a well-established technique for evaluation of colorectal cancer. Significant advances have been made in the technique of CT colonoscopy since its inception. Excellent results can be achieved in detecting both colorectal cancer and significant sized polyps as long as a meticulous technique is adopted while performing CT colonoscopy. Furthermore, it is important to realize that there is a learning curve involved in interpreting these studies and adequate experience is essential to achieve high sensitivity and specificity with this technique. Indications, contraindications, technique and interpretation, including potential pitfalls in CT colonoscopy imaging, are reviewed in this article. Recent advances and the current role of CT colonoscopy in colorectal cancer screening are also discussed. | Dhakshina Ganeshan Khaled M Elsayes David Vining | 2013 | World Journal of Radiology2013，5，3： | 4 |
| 5 | Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma显示文摘瞄准:评估牛角属 procera 的弄干的乳胶(DL ) 的反癌症性质,热带药用的植物,在肝细胞癌并且到的 X15-myc 转基因的老鼠模型阐明它在房间文化的行动的机制。方法:小转基因的老鼠口头上地为 15 wk 用 DL (为 5 d/wk 的 400 mg/kg ) 的水的暂停被喂,他们的肝在 20 wk 为组织病理学说的变化被检验。脉管的内皮生长因素(VEGF ) 的浆液层次也在这些动物被测量。描绘活跃部分, DL 被提取,石油醚由甲醇列在后面。methanolic 摘录是用非极、极的溶剂的联合的硅胶 G 列上的亚 fractionated,十一部分被获得。每部分用 tetrazolium (MTT ) 在肝细胞瘤(Huh7 )(AML12 ) 和 non-hepatoma (COS-1 ) 房间行和非转变的 hepatocytes 上为细胞毒素的效果被分析试金。最后,细胞死亡的机制被测量 Bcl2 的层次调查, caspase 3 并且 DNA 破碎。结果:老鼠的 DL 处理对 hepatocarcinogenesis 显示出完全的保护。没有不利效果在这些动物被观察。浆液 VEGF 水平显著地作为与对照动物相比在对待的老鼠被降低。当 AML12 房间被节省时,房间文化研究表明 methanolic 在 Huh-7 和 COS-1 房间 DL 以及它的部分提取 8 导致的广泛的细胞死亡。这被 DNA 的广泛的破碎在 Huh-7 和 COS-1 房间伴随。在象 Bcl2 和 caspase 那样的 apoptosis 的正规标记的层次的没有变化 3 被观察。结论:C 的 DL。procera 与 apoptosis 的常规小径由于它的可辨的目标和不干涉为反癌症治疗有潜力。 | Tenzin Choedon Ganeshan Mathan Soneera Arya Vijay L Kumar Vijay Kumar | 2006 | World Journal of Gastroenterology2006，12，16： | 3 |
| 6 | p-Coumaric acid ameliorates ethanol-induced kidney injury by inhibiting inflammatory cytokine production and NF-κB signaling in rats显示文摘Objective: To examine the effects of p-coumaric acid on ethanol-induced kidney injury in Swiss Wistar rats.Methods: Ethanol(25% v/v) was used to induce nephrotoxicity in rats. p-Coumaric acid was orally administered at 50, 100, or 200 mg/kg body weight. The levels of oxidative parameters were determined; pro-inflammatory biomarkers were analyzed by Western blotting and apoptotic protein was analyzed by immunohistochemistry. Results: Ethanol treated rats showed decreased levels of antioxidants and aberrant production of pro-inflammatory cytokines(IL-6, IL1β, TNF-α), NF-κB activation and imbalance of proand anti-apoptotic proteins(Bcl-2, Bax, caspase 3). Meanwhile, p-coumaric acid restored antioxidant levels and decreased the levels of inflammatory cytokines, NF-κB, and proapoptotic proteins and increased Bcl-2 expression. Conclusions: p-Coumaric acid ameliorates ethanol-induced kidney injury by restoring antioxidant production and suppressing cellular apoptosis and inhibiting NF-κB expression.p-Coumaric acid should be further investigated as a promising candidate for ethanol-induced kidney toxicity. | Ramakrishnan Sabitha Kumari Nishi Vinoth Prasanna Gunasekaran Govindhan Annamalai Balupillai Agilan Mathan Ganeshan | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，5： | 2 |
| 7 | Features of primary pancreatic lymphoma:A bi-institutional review with an emphasis on typical and atypical imaging features显示文摘BACKGROUND Primary pancreatic lymphoma(PPL)is a rare neoplasm.Being able to distinguish it from other pancreatic malignancies such as pancreatic ductal adenocarcinoma(PDAC)is important for appropriate management.Unlike PDAC,PPL is highly sensitive to chemotherapy and usually does not require surgery.Therefore,being able to identify PPL preoperatively will not only direct physicians towards the correct avenue of treatment,it will also avoid unnecessary surgical intervention.AIM To evaluate the typical and atypical multi-phasic computed tomography(CT)imaging features of PPL.METHODS A retrospective review was conducted of the clinical,radiological,and pathological records of all subjects with pathologically proven PPL who presented to our institutions between January 2000 and December 2020.Institutional review board approval was obtained for this investigation.The collected data were analyzed for subject demographics,clinical presentation,laboratory values,CT imaging features,and the treatment received.Presence of all CT imaging findings including size,site,morphology and imaging characteristics of PPL such as the presence or absence of nodal,vascular and ductal involvement in these subjects were recorded.Only those subjects who had a pre-treatment multiphasic CT of the abdomen were included in the study.RESULTS Twenty-nine cases of PPL were diagnosed between January 2000 and December 2020(mean age 66 years;13 males/16 females).All twenty-nine subjects were symptomatic but only 4 of the 29 subjects(14%)had B symptoms.Obstructive jaundice occurred in 24%of subjects.Elevated lactate dehydrogenase was seen in 81%of cases,whereas elevated cancer antigen 19-9 levels were present in only 10%of cases for which levels were recorded.The vast majority(90%)of tumors involved the pancreatic head and uncinate process.Mean tumor size was 7.8 cm(range,4.0-13.8 cm).PPL presented homogenous hypoenhancement on CT in 72%of cases.Small volume peripancreatic lymphadenopathy was seen in 28%of subjects.Tumors demonstrated encasement of superior mesenteric vessels in 69%of cases but vascular stenosis or occlusion only manifested in 5 out of the twentynine individuals(17%).Mild pancreatic duct dilatation was also infrequent and seen in only 17%of cases,whereas common bile duct(CBD)dilation was seen in 41%of subjects.Necrosis occurred in 10%of cases.Size did not impact the prevalence of pancreatic and CBD dilation,necrosis,or mesenteric root infiltration(P=0.525,P=0.294,P=0.543,and P=0.097,respectively).Pancreatic atrophy was not present in any of the subjects.CONCLUSION PPL is an uncommon diagnosis best made preoperatively to avoid unnecessary surgery and ensure adequate treatment.In addition to the typical CT findings of PPL,such as homogeneous hypoenhancement,absence of vascular stenosis and occlusion despite encasement,and peripancreatic lymphadenopathy,this study highlighted many less typical findings,including small volume necrosis and pancreatic and bile duct dilation. | Nicole Segaran Kumaresan Sandrasegaran Catherine Devine Mindy X Wang Chintan Shah Dhakshinamoorthy Ganeshan | 2021 | World Journal of Clinical Oncology2021，12，9： | 2 |
| 8 | Optimal procurement portfolios when using B2Bs: A model and analysis显示文摘 | Ganeshan R Boone T Aggarwal P | 2009 | International Journal of Production Economics2009，118，1： | 1 |
| 9 | Inventory control under gamma demand and randon lead time显示文摘 | Tyworth J E Guo Y Ganeshan R | 1996 | Journal of bussiness logistics1996，17，1： | 1 |
| 10 | Ladder-type Diindenopyrazine Based Conjugated Copolymers for Organic Solar Cells with High Open-circuit Voltages显示文摘当为构造的一块积木结合了共聚物,梯子类型 diindenopyrazine (IPY ) 被综合并且使用。三共聚物经由与不同单体联合反应的铃木基于 IPY 一半被获得,包括 4,7-dithien-2-yl-2,1,3-benzothiadiazole (DBT ) , 5,8-dithien-2-yl-2,3-diphenylquinoxaline (DTQ ) ,和 5,8-dithien-2-yl-2,3-di (4-fluorophenyl ) quinoxaline (DFTQ ) 。获得的聚合物被 1H NMR 光谱学,紫外力的吸收光谱学,周期的 voltammetry,和胶化浸透层析(GPC ) 描绘。由于 IPY 单位上的四增溶的烷基链,所有三共聚物在普通溶剂有好溶解度。这些聚合物在 5.555.60 eV,和展览的范围有 deep-lying 人精力层次 ? 象 0.006 cm2 瑵愠瑮 ? 牡浯瑡捩爠灥慥楴杮甠楮獴椠瑮 ? 一样高的高龄效果活动性潣橮杵瑡摥瀠汯浹牥 ? 慨 ?敢湥攠灸潬敲 | Shanci Chen Changquan Tang Zhigang Yin Yunlong Ma Dongdong Cai Dhanavel Ganeshan Qingdong Zheng | 2013 | Chinese Journal of Chemistry2013，31，11： | 1 |
| 11 | Using Risk-Management Tools on B2Bs: An Exploratory Investigation显示文摘 | Aggarwal P R Ganeshan | 2007 | International Journal of Production Economics2007，108，12： | 1 |
| 12 | Managing supply chain inventories: A multiple retailer, one warehouse, multiple supplier model显示文摘 | Ram Ganeshan | 1999 | Int J Production Economics1999，59，： | 1 |
| 13 | Object-oriented Model for Integrating Construction Product and Process Information显示文摘 | Stumpf A Ganeshan R | | 0，，3： | 1 |
| 14 | Endovascular Treatment Options in the Management of Lower Limb Deep Venous Thrombosis显示文摘 | Sarfraz Ahmed Nazir Arul Ganeshan Sheraz Nazir Raman Uberoi | 2009 | CardioVascular and Interventional Radiology2009，，5： | 1 |
| 15 | Hepatic enhancement in colorectal cancer texture analysis correlates with hepatic hemodynamics and patient survival显示文摘 | Ganeshan B Miles KA Young RC | 2007 | Acad Radiol2007，14，12： | 1 |
| 16 | Inventory control under gamma demand and random demand显示文摘 | John E Tyworth Ram Ganeshan | 1996 | Journal of Business Logistics1996，17，1： | 1 |
| 17 | Cerebral venous thrombosis-A pictorial review显示文摘 | Ganeshan D Narlawar R McCann C | | 0，，： | 1 |
| 18 | Managing supply chain inventories:Amuhiple re- tailer,one warehouse, multiple supplier model显示文摘 | Ram Ganeshan | | Int J0，，： | 1 |
| 19 | Imaging of the aor- tic valve with MRI and CT angiography显示文摘 | Harvey J J Hoey ET Ganeshan A | 2013 | Clin Radi- o/2013，68，12： | 1 |
| 20 | Imaging of primary and sec- ondary renal lymphoma显示文摘 | Ganeshan D lyer R Devine C | 2013 | AJR2013，201，5： | 1 |
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