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| 1 | Tissue expression and developmental regulation of chicken cathelicidin antimicrobial peptides显示文摘Cathelicidins are a major family of antimicrobial peptides present in vertebrate animals with potent microbicidal and immunomodulatory activities. Four cathelicidins, namely fowlicidins 1 to 3 and cathelicidin B1, have been identified in chickens. As a first step to understand their role in early innate host defense of chickens, we examined the tissue and developmental expression patterns of all four cathelicidins. Real-time PCR revealed an abundant expression of four cathelicidins throughout the gastrointestinal, respiratory, and urogenital tracts as well as in all primary and secondary immune organs of chickens. Fowlicidins 1 to 3 exhibited a similar tissue expression pattern with the highest expression in the bone marrow and lung, while cathelicidin B1 was synthesized most abundantly in the bursa of Fabricius. Additionally, a tissue-specific regulatory pattern was evident for all four cathelicidins during the first 28 days after hatching. The expression of fowlicidins 1 to 3 showed an age-dependent increase both in the cecal tonsil and lung, whereas all four cathelicidins were peaked in the bursa on day 4 after hatching, with a gradual decline by day 28. An abrupt augmentation in the expression of fowlicidins 1 to 3 was also observed in the cecum on day 28, while the highest expression of cathelicidin B1 was seen in both the lung and cecal tonsil on day 14. Collectively, the presence of cathelicidins in a broad range of tissues and their largely enhanced expression during development are suggestive of their potential important role in early host defense and disease resistance of chickens. | Mallika Achanta Lakshmi T Sunkara Gan Dai Yugendar R Bommineni Weiyu Jiang Guolong Zhang | 2012 | Journal of Animal Science and Biotechnology2012，3，2： | 3 |
| 2 | Emulation of neutron irradiation effects with protons: validation of principle显示文摘 | G.S Was J.T Busby T Allen E.A Kenik A Jensson S.M Bruemmer J Gan A.D Edwards P.M Scott P.L Andreson | 2002 | Journal of Nuclear Materials2002，，2： | 2 |
| 3 | A review of the pharmacokinetics and pharmacodynamics of remifentanil显示文摘 | GLASS P S GAN T J HOWELL S | 1999 | Anesth Analg1999，，： | 1 |
| 4 | Perioperative fluid management and clinical outcomes in adults 显示文摘 | Grocott M P Mythen M G Gan T J | 2005 | Anesth Analg2005，100，： | 1 |
| 5 | Double-quantum filtered STMAS显示文摘 | Kwak H T Gan Z | 2003 | J Mag Reson2003，164，2： | 1 |
| 6 | The sphingomonas species UG30 pentachlorophenol-4-monooxygenase in p-nitrophenol degradation显示文摘 | LEUNG K T CAMPBELL S GAN Y | 1999 | Fems Microbiology Letters1999，173，1： | 1 |
| 7 | Consensus guidelines for managing postoperative nausea and vomiting 显示文摘 | GAN TJ MEYER T APFEL CC | 2003 | Anesth Analg2003，97，1： | 1 |
| 8 | A comparison of the efficacy,safety,and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procedure显示文摘 | GAN T J GRACZYK S | 1998 | Anesth Analg1998，86，： | 1 |
| 9 | Comparison of the mor-phine sparing effects of diclofenac sodium and ketorolactromethamine after major orthopedic surgery显示文摘 | Alexander R El-Moalem H E Gan T J | 2002 | J Clin Anesth2002，14，3： | 1 |
| 10 | A new surface-inset, permanent-magnet, brushless DC motor drive for electric vehicles显示文摘 | Gan J Y Chau K T Chan C C | 2000 | IEEE Transactions on Magnetics2000，36，5： | 1 |
| 11 | Dielectric property of (TiO2)x-(Ta2O5)l-x thin films显示文摘 | Gan J Y Chang Y C Wu T B | 1998 | Applied Physics Letters1998，72，3： | 1 |
| 12 | Alterations in the ex-pression of atrial calpains in electrical and structural re-modeling during aging and atrial fibrillation 显示文摘 | Xu G J Gan T Y Tang B P | 2013 | Mol Med Rep2013，8，5： | 1 |
| 13 | Dynamic effect of di-2-(ethylhexyl) phthalate on testicular toxicity: epigenetic changes and their impact on gene expression显示文摘 | Wu S Zhu J Li Y Lin T Gan L Yuan X | 2010 | Int J Toxicol2010，29，2： | 1 |
| 14 | 查看详情显示文摘 | Velayutham T S Abd Majid W H Gan W C Khorsand Zak A et at | | 0，，05： | 1 |
| 15 | Consensus guide- lines for the management of postoperative nausea and vomiting显示文摘 | GAN T J DIEMUNSCH P HABIB A S | 2014 | Anesth Analg2014，118，10： | 1 |
| 16 | 显示文摘 | Gan L M Li T D Chew C H | 1995 | Langmuir1995，11，： | 1 |
| 17 | Crystalline/Amorphous Phase Structure and Molecular Mobility of Biodegradable Poly( Butylenes Adipate-co-Butylene Terephthalate) and Related Polyesters显示文摘 | Kuwabara K Gan Zhihua Nakamura T | 2002 | Biomacromolecules2002，3，： | 1 |
| 18 | Pnstharvest residual soil nutrients and yield of spring wheat under water deficit in arid northwest China 显示文摘 | Zhang H J Gan Y T Huang G B | 2009 | Agricuhural Water Management2009，96，6： | 1 |
| 19 | Fast and efficient compressive sensing using structurally random matrices 显示文摘 | DO T T GAN L NGUYEN N | 2012 | IEEE Transactions on Signal Processing2012，60，1： | 1 |
| 20 | Forty-five patients with cirrhosis and clinical analysis of upper gastrointestinal hemorrhage显示文摘 | Gan T | 2010 | Chinese medicine guide2010，8，7： | 1 |
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