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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Menopause and colorectal cencer显示文摘 | Francesehi 5 Gallus S Talamini R | 2000 | Br J Cancer2000，82，11： | 1 |
| 3 | Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys:A pooled analysis显示文摘 | Clifford GM Gallus S H errero R | 2005 | Lancet2005，366，9490： | 1 |
| 4 | Warfarin reversal: consensus guidelines, on be- half of the Australasian Society of Thrombosis and Haemostasis显示文摘 | BAKER R I COUGHLIN P B GALLUS A S | 2004 | Med J Aust2004，181，： | 1 |
| 5 | Design and rotor performance of a 5 : 1 mixed-flow supersonic compressor显示文摘 | Monig R Elmendorf W Gallus H E | 1993 | ASME Journal of Turbomachinery1993，115，： | 1 |
| 6 | Participatory ergonomics:Development of an employee assessment questionnaire 显示文摘 | Matthews R A Gallus J A Henning R A | 2011 | Accident Analysis and Prevention2011，43，1： | 1 |
| 7 | The role of septal surgery in cosmetic rhinoplasty显示文摘 | Parrilla C Artuso A Gallus R | 2013 | Acta Otorhinolaryngol Ital2013，33，3： | 1 |
| 8 | Worldwide distribution of human papillomavirus types in cytologically normal women in the International agency for research on cancer HPV prevalence surveys:a pooled analysis显示文摘 | Clifford G M Gallus S Herrero R | 2005 | Lancet2005，366，9490： | 1 |
| 9 | Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis 显示文摘 | CLIFFORD G M GALLUS S HERRERO R | 2005 | Lancet2005，366，9490： | 1 |
| 10 | Alcohol and the risk of prostate cancer and benign prostatic hyperplasia显示文摘 | Crispo A Talamini R Gallus S | 2004 | Urology2004，64，4： | 1 |
| 11 | Risk factors for prostate cancer in men aged less than 60 years: a case control study from Italy显示文摘 | Gallus S Foschi R Talamini R | 2007 | Urology2007，70，6： | 1 |
| 12 | Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: A pooled analysis 显示文摘 | Clifford G M Gallus S Herrero R | 2005 | Lancet2005，366，9490： | 1 |
| 13 | Worldwide distribution of human papillomavirus types in cytologically normal women in the international Agency for research on caner HPV prevalence surveys: apooled analysis显示文摘 | Clifford GM Gallus S Herrero R etal | 2005 | Cancet2005，366，9490： | 1 |
| 14 | Worldwide distribution of human papil- lomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys:a pooled analysis 显示文摘 | Clifford GM Gallus S Herrero R | 2005 | Lancet2005，366，9490： | 1 |
| 15 | Menopause andcolorectal cancer显示文摘 | Franceshi S Gallus S Talamini R | 2000 | Br J Cancer2000，82，11： | 1 |
| 16 | Worldwide distribution of human papillomavirus types in cytologically normal WOlYlen in the International Agency for Research On Canc- er HPV prevalence surveys: a pooled analysis 显示文摘 | Clifo GM Gallus S Herrem R | 2005 | Lancet2005，366，9490： | 1 |
| 17 | Worldwide distribution ofhuman papillomavirus types in cytologically normal women in theInternational Agency for Research on Cancer HPV prevalencesurveys: a pooled analysis 显示文摘 | Clifford GM Gallus S Herrero R | 2005 | Lancet2005，，69： | 1 |
| 18 | Worldwide distribu-tion of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys:a prevalence surveys:a pooled a-nalysis显示文摘 | Clifford GM Gallus S Herrero R | 2005 | Lancet2005，366，： | 1 |
| 19 | Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys:a pooled analysis显示文摘 | Clifford GM Gallus S Herrero R | 2005 | Lancet2005，366，9490： | 1 |
| 20 | Tobacco smoking, alcohol consumption and pancreatic cancer risk :a case- control study in Italy显示文摘 | Talamini R Polesel J Gallus S | 2010 | Eur J Cancer2010，46，2： | 1 |
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