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| 1 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 2 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 3 | A tandemly repeated sequence at the termini of the extra chromosomal ribosonal RNA genes in Tetrahymena显示文摘 | Blackburn E H Gall J G | 1978 | Mol Biol1978，120，： | 1 |
| 4 | Secoviridae:a proposed family of plant viruses within the order Picornavirales that combines the families Sequiviridae and Comoviridae,the unassigned genera Cheravirus and Sadwavirus and the proposed genus Torradovirus显示文摘 | SANFACON H WELLINK J LE GALL O | 2009 | Archives of Virol2009，，154： | 1 |
| 5 | Green Purchasing Strategies: Trends and Implications显示文摘 | Min H and Galle P | 1997 | Journal of Supply Chain Management1997，33，3： | 1 |
| 6 | Mice, melatonin and the circadian system 显示文摘 | KORF H W VON GALL C | 2006 | Mol Cell Endocrinol2006，252，12： | 1 |
| 7 | Molecular variation in the nucleoprotein gene(ORF7) of the porcine reproductive and respiratory syndrome virus (PRRSV)显示文摘 | Le Gall A L Legeay O Bourhy H | 1998 | Virus Research1998，54，1： | 1 |
| 8 | Effect of microstructure on the fatigue of hot-rolled and cold-drawn Ni-Ti shape memory alloys 显示文摘 | GALL K TYBER J WILKESANDERS G ROBERTSON S W R1TCHIE R O MAIER H J | 2008 | Materials Science and Engineering A2008，486，12： | 1 |
| 9 | Instrumented micro-indentation of NiTi shape-memory alloys显示文摘 | GALL K JUNTUNEN K MAIER H J SEHITOGLU H CHUMLYAKOV Y I | 2001 | Acta Materialia2001，49，： | 1 |
| 10 | 查看详情显示文摘 | Gall K Lim T J Mcdowell D L Sehitoglu H Chumlyakov Y I | | 0，，： | 1 |
| 11 | Cyclic deformation mechanisms in precipitated NiTi shape memory alloys显示文摘 | GALL K MAIER H J | 2002 | Acta Materialia2002，50，： | 1 |
| 12 | Secoviridae: a proposed family of plant viruses within the order Picor- navirales that combines the families Sequiviridae and Comoviridae, the unassigned genera Cheravirus and Sadwavirus, and the proposed genus Torradovirus显示文摘 | Sanfacon H Wellink J Gall O L | 2009 | Arch Virol2009，154，： | 1 |
| 13 | Thermal processing of polycrystalline Ni-Ti shape memory alloys 显示文摘 | FRICK C P ORTEGA A M TYBER J MAKSOUND A E M MAIER H J LIU Y N GALL K | 2005 | Materials Science and Engineering A2005，405，12： | 1 |
| 14 | The 1979 - 2005 Greenland ice sheet melt extent from passive microwave data using an improved version of the melt retrieval XPGR algorithm显示文摘 | Fettweis X van Ypersele J P Galle' e H | 2007 | Geophysical Research Letters2007，34，5： | 1 |
| 15 | 2005, Deposition velocities to Sorbus aria, Acer campestre, Populusdeltoidstrichocarpa 'Beaupre', Pinusnigra and Cupressocyparisleylandii for coarse, fine and ultra-fine particles in the urban environment 显示文摘 | FREER-SMITH P H KPBECKETT GAlL TAYLOR | 2005 | EnvironmentalPollution2005，133，1： | 1 |
| 16 | Green Purchasing strategies: Trends and Implications显示文摘 | Min H Galle W P | 1997 | International Journal of Purchasing and Materials Management1997，33，3： | 1 |
| 17 | Identification of placental cytokine-producing cells in term and preterm labor 显示文摘 | Steinbom A von Gall C Hildenbrand R Stutte H J Kaufmann M | 1998 | Obstet Gynecol1998，91，3： | 1 |
| 18 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 19 | A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in tetrahymena 显示文摘 | Blackburn E H Gall J G | 1978 | J Mol Biol1978，120，： | 1 |
| 20 | Anaphylactic shock reaction to dibutyl-phthalate-containing capsules显示文摘 | Gall H Kaehler A Peter RU | 1999 | Dermatology1999，199，： | 1 |
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