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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Fundamentals of spiral grooved noncontacting face seals 显示文摘 | Gabriel R P | 1994 | Lubrication Engineering1994，3，： | 1 |
| 3 | Fundamentals of spiral groove non - contacting face seals显示文摘 | Gabriel R P | 1994 | Lubr Eng1994，50，3： | 1 |
| 4 | Stroke Volume Variation as an Indicator ofFluid Responsiveness Using Pulse Contour Analysis in Mechanically Ventilated Patients显示文摘 | Christopher P Gabriele R | 2003 | Anesth Analg2003，96，5： | 1 |
| 5 | Fundamentals of Spiral Groove Non-contacting Face Seals 显示文摘 | Gabriel R P | 1994 | Lubrication Engineering1994，50，： | 1 |
| 6 | Fundamentals of spiral groove noncontact- ing face seals 显示文摘 | Gabriel R P | 1994 | Lubrication Engineering1994，50，3： | 1 |
| 7 | Lung perfusion during cardiac surgery with cardiopulmonary bypass: is it necessary? 显示文摘 | Gabriel EA Fagionato Lcali R Katsumi Matsuoka P | 2008 | Interact CardioVasc Thorac Surg2008，7，6： | 1 |
| 8 | Fundamentals of Spiral Groove Non - Contacting Face Seals 显示文摘 | Gabriel R P | 1994 | Lubrication Engineering1994，50，3： | 1 |
| 9 | Hyperthermia and radiation therapy for inoperable or recurrent parotid carcinoma显示文摘 | Gabriele P Amichetti M Orecchia R | 1995 | Cancer1995，75，4： | 1 |
| 10 | The influence of layered compounds on the properties of starch/layered compound composites 显示文摘 | Helena - M Wilhelm Maria - R Sierakowski Gabriel P Souza | 2003 | Polymer International2003，52，： | 1 |
| 11 | Fundamentals of spiral groove non-contacting face seals 显示文摘 | Gabriel R P | 1994 | Lubrication Engineering1994，50，2： | 1 |
| 12 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 13 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 14 | Fundamentals of spiral groove noncontacting faceseals 显示文摘 | Gabriel R P | 1994 | Lubrication Engineering1994，50，3： | 1 |
| 15 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 16 | Would species richness estimators change the observed species area relationship显示文摘 | BORGES P A V HORTAL J GABRIEL R | 2009 | Acta Oecologica2009，35，1： | 1 |
| 17 | Fundamentals of spiral Groove non-contacting face seals 显示文摘 | Gabriel R P | 1994 | Lubrication Engineering1994，50，3： | 1 |
| 18 | ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma 显示文摘 | Carlo P Gabriele D Antonietta R | 2008 | PNA2008，105，19： | 1 |
| 19 | Fundamentals of Spiral Groove Non- Contacting Face Seals 显示文摘 | Gabriel R P | 1994 | Lubrication Engineering1994，，3： | 1 |
| 20 | A multi-criteria job scheduling framework for large computing farms显示文摘 | BARAGLIA R C GABRIELE D P PAGANO G | 2013 | Journal of Com- puter and System Sciences2013，79，2： | 1 |
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