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| 1 | Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)represents a global health problem.Infections with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this tumor.Regardless of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis.Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence motifs.Here,we summarize the current literature implicating galectins in the pathogenesis of HCC.Expression of'proto-type'galectin-1,'chimera-type'galectin-3 and'tandem repeat-type'galectin-4 is up-regulated in HCC cells compared to their normal counterparts.On the other hand,the'tandemrepeat-type'lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes.The abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor prognosis.Moreover,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take place.Galectin-based therapies have been proposed to attenuate liver pathologies.Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC. | María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F Troncoso | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 2 | Prediction of firmness and soluble solids content of blueberries using hyperspectral reflectance imaging显示文摘 | GABRIEL A L LU R F AGUILERA J M | 2013 | Journal of Food Engineering2013，115，： | 1 |
| 3 | Differential degradation of nonylphenol isomers by Sphingomonas xenophaga bayram显示文摘 | Gabriel F L P Giger W Guenther K | 2005 | Applied and Environmental Microbiology2005，71，3： | 1 |
| 4 | A functional cloning strategy, based on a binary PVX-expression vector, to isolate HR-inducing cDNAs of plant pathogens 显示文摘 | Takken F L W Luderer R Gabriels S H E J | 2000 | The Plant Journal2000，24，2： | 1 |
| 5 | A novel metabolic pathway for degradation of 4-nonylphenol environmental contaminants by Sphingomonas xenophaga Bayram: ipso-hydroxylation and intramolecular rearrangement 显示文摘 | GABRIEL F L P HEIDLBERGER A RENTSCH D | 2005 | Journal of Biological Chemistry2005，280，15： | 1 |
| 6 | Corrosion behaviour of magnesium sacrificial anodes in tap water显示文摘 | ANDREI M GABRIELE F D BONORA P L | 2003 | Materials and Corrosion2003，54，5： | 1 |
| 7 | Differential degradation of nonylphenol isomers by Sphingomonas xenophaga Bayram 显示文摘 | Gabriel F L Giger W Guenther K | 2005 | Applied and Environmental Microbiology2005，71，3： | 1 |
| 8 | The use of microarray technologies in clinical oncology显示文摘 | Gabriele L Moretti F Pierotti MA | 2006 | J Transl Med2006，4，： | 1 |
| 9 | Differential degradation of nonylphenol isomers by Sphingomonas xenophaga Bayram 显示文摘 | Gabriel F L P Giger W Guenther K | 2005 | Applied and Environmental Microbiology2005，71，3： | 1 |
| 10 | Diterpenoid alkaloids from Delphinium pictum Willd显示文摘 | GABRIEL D L F RAFAEL D A TOMAS O | 1989 | Heterocycles1989，29，2： | 1 |
| 11 | Microtubule-interfering activi- ty of parthenofide 显示文摘 | Miglietta A Bozzo F Gabriel L | 2004 | Chem Biol Interact2004，149，23： | 1 |
| 12 | Multiphase reactor scale-up for Cu-C1 thermochemical hydrogen production 显示文摘 | Wang Z L Naterer G F Gabriel K | 2008 | International Jour- nal of Hydrogen Energy2008，33，23： | 1 |
| 13 | New Cu-C1 thermochemi- eal cycle for hydrogen production with reduced excess steam re- quirements 显示文摘 | Wang Z L Naterer G F Gabriel K | 2009 | International Journal of Green Ejaergy2009，6，6： | 1 |
| 14 | Multiplex Lateral-Flow Test Strips Fabricated by Two-Dimensional Shaping 显示文摘 | Erin M F Monica R M Gabriel P L | 2009 | Applied Materials and Interfaces2009，1，1： | 1 |
| 15 | New DGGE strategies for the analyses of methanotrophic microbial communities using different combinations of existing 16S rRNA-based primers 显示文摘 | Paul L E B Marion M F Gabriel Z | 2005 | FEMS Microbiology Ecologyl2005，52，2： | 1 |
| 16 | Comparison of different copper-chlorine thermochemical cycles for hydrogen production 显示文摘 | Wang Z L Naterer G F Gabriel K S | 2009 | International Joumal of Hydrogen Energy2009，34，8： | 1 |
| 17 | Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathway 显示文摘 | Bocca C Bozzo F Gabriel L | 2007 | The Journal of Nutritional Biochemistry2007，18，5： | 1 |
| 18 | Type I interferons as stimulators of DC - mediated cross - priming: impactonanti - tumor response 显示文摘 | Schiavoni G Mattei F Gabriele L | 2013 | FrontImmuno12013，4，12： | 1 |
| 19 | Risk of connective tissue disease and other disorders after breast implantation显示文摘 | Gabriel S E OFallon W F Kurland L T | 1994 | N Engl J Med1994，330，： | 1 |
| 20 | Corrosion behavior of magnesium sacrificial anodes in tap water 显示文摘 | Andrei M Gabriele F D Bonora P L | 2003 | Materials and Corrosion2003，54，5： | 1 |
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