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| 1 | Adjunctive aripiprazole for antipsychotic-related hyperprolactinaemia in patients with first-episode schizophrenia:a metaanalysis显示文摘Background Hyperprolactinaemia is a common antipsychotic(AP)-induced adverse effect,particularly in female patients.Aims This meta-analysis examined the efficacy and safety of adjunctive aripiprazole in preventing AP-related hyperprolactinaemia in patients with first-episode schizophrenia.Methods PubMed,PsycINFO,EMBASE,Cochrane Library,WanFang and China Journal Net databases were searched to identify eligible randomised controlled trials(RCTs).Primary outcomes were the reductions of serum prolactin level and prolactin-related symptoms.Data were independently extracted by two reviewers and analysed using RevMan(V.5.3).Weighted/standardised mean differences(WMDs/SMDs)±95%Cis were reported.Results In the five RCTs(n=400),the adjunctive aripiprazole(n=197)and the control groups(n=203)with a mean of 11.2 weeks of treatment duration were compared.The aripiprazole group had a significantly lower endpoint serum prolactin level in all patients(five RCTs,n=385;WMD:-50.43 ng/mL(95%Cl:-75.05 to-25.81),p<0.00001;l2=99%),female patients(two RCTs,n=186;WMD:-22.58 ng/mL(95%Cl:-25.67 to-19.49),p<0.00001;l2=0%)and male patients(two RCTs,n=127;WMD:-68.80 ng/mL(95%Cl:-100.11 to-37.49),p<0.0001).In the sensitivity analysis for the endpoint serum prolactin level in all patients,the findings remained significant(p<0.00001;l2=96%).The aripiprazole group was s叩erior to the control group in improving negative symptoms as assessed by the Positive and Negative Syndrome Scale(three RCTs,n=213;SMD:-0.51(95%Cl:-0.79 to-0.24),p=0.0002;l2=0%).Adverse effects and discontinuation rates were similar between the two groups.Conclusions Adjunctive aripiprazole appears to be associated with reduced AP-induced hyperprolactinaemia and improved prolactin-related symptoms in first-episode schizophrenia.Further studies with large sample sizes are needed to confirm these findings. | Wei Zheng Dong-Bin Cai Xin-Hu Yang Wei Zheng Gabor S Ungvari Chee H Ng Zhan-Ming Shi Mei-Ling Hu Yu-Ping Ning Yu-Tao Xiang | 2019 | General Psychiatry2019，32，5： | 4 |
| 2 | Adjunctive Peony-Glycyrrhiza decoction for antipsychotic-induced hyperprolactinaemia:a meta-analysis of randomised controlled trials显示文摘Background Hyperprolactinaemia is a common adverse effect of antipsychotics(APs). The results of PeonyGlycyrrhiza decoction(PGD) as a potentially useful adjunctive treatment for hyperprolactinaemia are inconsistent.Aim This meta-analysis of randomised controlled trials(RCTs) examined the efficacy and safety of adjunctive PGD therapy for AP-induced hyperprolactinaemia.Methods English(PubMed, Embase, Cochrane Library,PsycINFO) and Chinese(Chinese National Knowledge Infrastructure, Wanfang Data) databases were systematically searched up to 10 June 2018. The inclusion criteria were based on PIC0 S一/^rticipants: adult patients with schizophrenia; Aitervention: PGD plus APs; Cbmparison: APs plus placebo or AP monotherapy;(Xjtcomes: efficacy and safety; Study design: RCTs. The weighted mean difference(WMD) and risk ratio(RR) along with their 95% CIs were calculated using Review Manager(RevMan) V.5.3 software.Results Five RCTs(n=450) were included and analysed.Two RCTs(n=140) were double-blind and four RCTs(n=409) reported ‘random' assignment with specific description. The PGD group showed a significantly lower serum prolactin level at endpoint than the control group(n=380, WMD:-32.69 ng/mL(95% Cl-41.66 to 23.72),/X0.00001, ^=97%). Similarly, the superiority of PGD over the control groups was also found in the improvement of hyperprolactinaemia-related symptoms. No difference was found in the improvement of psychiatric symptoms assessed by the Positive and Negative Syndrome Scale(n=403,WMD:-0.62(95% Cl-2.38 to 1.15), p=0.49, ^=0%). There were similar rates of all-cause discontinuation(n=330, RR0.93(95% Ci 0.63 to 1.37),/t=0.71, ^=0%) and adverse drug reactions between the two groups. According to the Grading of Recommendations Assessment, Development and Evaluation approach, the level of evidence of primary and secondary outcomes ranged from ‘very low'(14.3%),‘low'(42.8%),‘moderate'(14.3%),to ‘high,(28.6%>.Conclusions Current evidence supports the adjunctive use of PGD to suppress elevated prolactin and improve prolactininduced symptoms without significant adverse events in adult patients with AP-induced hyperprolactinaemia. Highquality RCTs with longer duration are needed to confirm these findings.Trial registration number 42016037017. | Wei Zheng Dong-Bin Cai Hai-Yan Li Yu-Jie Wu Chee H Ng Gabor S Ungvari Shan-Shan Xie Zhan-Ming Shi Xiao-Min Zhu Yu-Ping Ning Yu-Tao Xiang | 2018 | General Psychiatry2018，31，4： | 3 |
| 3 | Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012显示文摘 | Yu-Xi Wang Yu-Tao Xiang Yun-Ai Su Qian Li Liang Shu Chee H Ng Gabor S Ungvari Helen FK Chiu Yu-Ping Nin Gao-Hua Wang Pei-Shen Bai Tao Li Li-Zhong Sun Jian-Guo Shi Xian-Sheng Chen Qi-Yi Mei Ke-Qing Li Xin Yu Tian-Mei Si | 2015 | Chinese Medical Journal2015，，14： | 2 |
| 4 | Complete genome sequence of simian adenovirus 1: an Old World monkey adenovirus with two fiber genes显示文摘 | Gabor MK Balazs H Alexander N | 2005 | Journal of General Virology2005，86，： | 1 |
| 5 | Surface shading in the cuberille environment 显示文摘 | Chen L S Gabor T H | 1985 | IEEE Computer Graphics and Application1985，5，12： | 1 |
| 6 | Early enteral feeding compared with parenteral nutrition after oesophageal or oesophagogastric resection and reconstruction显示文摘 | Gabor S Renner H Matzi V | 2005 | Br J Nutr2005，93，4： | 1 |
| 7 | Indications for sur- gery in tracheobronchial ruptures显示文摘 | Gabor S Renner H Pinter H | 2001 | Eur J Cardiothorac Surg2001，20，2： | 1 |
| 8 | Babesia canis canis in dogs from Hungary: detection by PCR and sequencing 显示文摘 | Gabor F Eva H Robert F | 2005 | Veterinary Parasitology2005，127，： | 1 |
| 9 | Extremely efficient multiple electron-hole pair generation in carbon nanotube photodiodes显示文摘 | Gabor N Zhong Z H Bosnick K | 2009 | Science2009，325，5949： | 1 |
| 10 | Steady-state thermal conductivity measurements of super-hard materials显示文摘 | KHORUNZHII I GABOR H JOB R | 2002 | Measurement:J of Int Measurement Confederation2002，32，3： | 1 |
| 11 | Indications for surgery in tracheobronchial ruptures 显示文摘 | Gabor S Renner H Pinter H | 2001 | Eur J Cardiothorac Surg2001，20，2： | 1 |
| 12 | Influence of heavy organic pollutants of anthrop icorigin on PAH retention by kaolinite显示文摘 | Gabor I H Saada A | 2001 | Chemosphere2001，44，7： | 1 |
| 13 | Band-gap engineering in Cu(In,Ga)Se2 thin films grown from (In,Ga)2Se3 precursors显示文摘 | Gabor A M Tuttle J R Bode M H | 1996 | Sol Energy Mater & Sol Cells1996，4142，： | 1 |
| 14 | Early enteral feeding compared with parenteral nutrition after oesophageal or oesophagogastric resection and reconstruction显示文摘 | Gabor S Renner H Matzi V | 2005 | Br J Nutr2005，93，4： | 1 |
| 15 | Cyclic stress-strain response and low-cycle fatigue damage in ultrafine grained copper显示文摘 | MAIER H J GABOR P KARAMAN I | | 0，，： | 1 |
| 16 | Detection of Uric Acid with New Type of Conducting Polymer-Based BnzymaticSensor by Bipotentiostatic Technique显示文摘 | Gabor H Csaba V | 1999 | Anal Chim ACTA1999，385，： | 1 |
| 17 | Cyclic stress strain re-sponse and low-cycle fatigue damage in ultrafine grained cop- per显示文摘 | Maier H J Gabor P Karaman I | 2005 | Mater SciEng A2005，，： | 1 |
| 18 | Indications for surgery in tracheo-bronchial ruptures 显示文摘 | Gabor S Renner H Pinter H | 2001 | Eur J Cardio -thoracic Surg2001，20，2： | 1 |
| 19 | Detection of uric with a new type of conducting polyner-based enzymatic sensor by biopotentiostatic technique显示文摘 | Robert D Gabor H Csaba V | 1999 | Analytica Chimica Acta1999，385，： | 1 |
| 20 | Cyclic Stress-strain Response and Low-cycle Fatigue Damage in Ultrafine Grained Copper显示文摘 | MAIER H J GABOR P KARAMAN I | | 0，，： | 1 |
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