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| 1 | Change in subfoveal choroidal thickness after argon laser panretinal photocoagulation显示文摘AIM:To evaluate changes in subfoveal choroidal thickness(SFCT) and macular thickness as measured by enhanced depth imaging spectral-domain optical coherence tomography(EDI-OCT) after argon laser panretinal photocoagulation(PRP) in patients with severe diabetic retinopathy.·METHODS:This prospective,comparative case series included 21 patients(28 eyes) with severe diabetic retinopathy.All patients underwent three sessions of PRP.The SFCT and macular thickness were measured using EDI-OCT at baseline and one week after completion of 3 sessions of PRP.·RESULTS:SFCT before PRP was(318.1±96.5)μm and increased to(349.9 ±108.3)μm(P =0.001) after PRP.Macular thickness significantly increased at one week after PRP(from 273.1 ±23.9μm at baseline vs 295.8 ±25.3μm at one week;P <0.001).No significant relationship between the changes in macular thickness and SFCT was observed(r =-0.13,P =0.52).·CONCLUSION:PRP induced increases in both SFCT and macular thickness.Changes in SFCT did not correlate with changes in macular thickness. | Ga Eun Cho Hee Yun Cho Yun Taek Kim | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 14 |
| 2 | Association of low muscle strength with metabolic dysfunctionassociated fatty liver disease:A nationwide study显示文摘BACKGROUND There is limited evidence regarding the association between muscle strength and metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the association between muscle strength and MAFLD in the general population in Korea.METHODS This nationwide representative cross-sectional study included 31649 individuals aged≥19 years who participated in the Korea National Health and Nutrition Examination Survey between 2015 and 2018.Odds ratios(ORs)and 95%confidence intervals(95%CIs)for MAFLD according to sex-specific quartiles of muscle strength,defined by relative handgrip strength,were calculated using multivariable logistic regression analysis.Additionally,multivariable logistic regression analysis was used to assess the association between muscle strength and probable liver fibrosis in patients with MAFLD.RESULTS Of all the participants,29.3%had MAFLD.The prevalence of MAFLD was significantly higher in the lower muscle strength quartile groups for all participants,sexes,and age groups(P<0.001).A 1.92-fold(OR=1.92,95%CI:1.70–2.16)and 3.12-fold(OR=3.12,95%CI:2.64–3.69)higher risk of MAFLD was observed in the lowest quartile(Q1)group than in the other groups(Q2–Q4)and the highest quartile(Q4)group,respectively.The ORs of MAFLD were significantly increased in the lower muscle strength quartile groups in a dose-dependent manner(P for trend<0.001).These associations persisted in both sexes.An inverse association between muscle strength and the risk of MAFLD was observed in all subgroups according to age,obesity,and diabetes mellitus.In patients with MAFLD,the odds of severe liver fibrosis were higher in Q1(OR=1.83,95%CI:1.25–2.69)than in other groups(Q2–Q4).CONCLUSION Among Korean adults,low muscle strength was associated with an increased risk of MAFLD and liver fibrosis in patients with MAFLD. | Gyu Bae Lee Youn Huh Sang Hyun Lee Byoungduck Han Yang-Hyun Kim Do-Hoon Kim Seon Mee Kim Youn Seon Choi Kyung Hwan Cho Ga Eun Nam | 2023 | World Journal of Gastroenterology2023，29，45： | 1 |
| 3 | Acute respiratory distress syndrome and severe pneumonitis after atezolizumab plus bevacizumab for hepatocellular carcinoma treatment:A case report显示文摘BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common cancers worldwide and has a high mortality.However,the treatment options for advanced HCC are limited to tyrosine kinase inhibitors,such as sorafenib and lenvatinib.Since previous regimens have an insufficient efficacy,the combination therapy of atezolizumab and bevacizumab(Ate/Bev)has been investigated,which showed an improvement in progression-free and overall survival.However,the adverse events of this combination therapy in advanced HCC have not been established.Herein,we report a novel case of an unresectable HCC and acute respiratory distress syndrome(ARDS)after a combination therapy of Ate/Bev.CASE SUMMARY An 82-year-old male visited our outpatient clinic for an incidentally detected liver mass.Liver magnetic resonance imaging and enhanced chest computed tomography(CT)were performed,which showed arterial hyperenhancement with washout in delayed phase suggesting HCC,and a well-defined metastatic solid nodule,respectively.F-18 fluorodeoxyglucose positron emission tomography(PET)-CT exhibited multiple hypermetabolic lesions in the iliac bone,lumbar vertebrae,and femur.Because of the high burden of the intrahepatic tumor,transarterial radioembolization was initially performed;after 37 d,a combination therapy of Ate/Bev was administered.The patient visited the emergency department three days after Ate/Bev treatment complaining of dyspnea.He was diagnosed with severe pneumonitis based on CT.Despite administering oxygen via a high-flow nasal cannula,the P/F ratio was only 74;therefore,the patient was diagnosed with ARDS based on the overall examination results.Low tidal volume with high positive end-expiratory pressure,sedative agents combined with a neuromuscular blocker,and a systemic steroid were promptly applied to manage the ARDS.However,the patient did not recover from the hypoxia and expired 31 h after being admitted.CONCLUSION Clinicians should be aware of severe pneumonitis due to the immune-related adverse events of this combination therapy,and patients should be closely monitored after therapy. | Su Hyeon Cho Ga Ram You Chan Park Sang-Geon Cho Jong Eun Lee Sung Kyu Choi Sung Bum Cho Jae Hyun Yoon | 2023 | World Journal of Gastrointestinal Oncology2023，15，5： | 0 |
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