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| 1 | Synthetic biodegradable functional polymers for tissue engineering:a brief review显示文摘Scaffolds play a crucial role in tissue engineering. Biodegradable polymers with great processing flexibility are the predominant scaffolding materials. Synthetic biodegradable polymers with well-defined structure and without immunological concerns associated with naturally derived polymers are widely used in tissue engineering. The synthetic biodegradable polymers that are widely used in tissue engineering, including polyesters, polyanhydrides, polyphosphazenes, polyurethane, and poly(glycerol sebacate) are summarized in this article. New developments in conducting polymers, photoresponsive polymers, amino-acid-based polymers, enzymatically degradable polymers, and peptide-activated polymers are also discussed. In addition to chemical functionalization, the scaffold designs that mimic the nano and micro features of the extracellular matrix(ECM) are presented as well, and composite and nanocomposite scaffolds are also reviewed. | GUO BaoLin MA Peter X | 2014 | Science China Chemistry2014，57，4： | 14 |
| 2 | Crop 3D a LiDAR based platform for 3D high-throughput crop phenotyping显示文摘With the growing population and the reducing arable land, breeding has been considered as an effective way to solve the food crisis.As an important part in breeding, high-throughput phenotyping can accelerate the breeding process effectively. Light detection and ranging(LiDAR) is an active remote sensing technology that is capable of acquiring three-dimensional(3 D) data accurately,and has a great potential in crop phenotyping. Given that crop phenotyping based on LiDAR technology is not common in China,we developed a high-throughput crop phenotyping platform, named Crop 3 D, which integrated LiDAR sensor, high-resolution camera, thermal camera and hyperspectral imager. Compared with traditional crop phenotyping techniques, Crop 3 D can acquire multi-source phenotypic data in the whole crop growing period and extract plant height, plant width, leaf length, leaf width, leaf area, leaf inclination angle and other parameters for plant biology and genomics analysis. In this paper, we described the designs,functions and testing results of the Crop 3 D platform, and briefly discussed the potential applications and future development of the platform in phenotyping. We concluded that platforms integrating LiDAR and traditional remote sensing techniques might be the future trend of crop high-throughput phenotyping. | Qinghua Guo Fangfang Wu Shuxin Pang Xiaoqian Zhao Linhai Chen Jin Liu Baolin Xue Guangcai Xu Le Li Haichun Jing Chengcai Chu | 2018 | Science China(Life Sciences)2018，61，3： | 14 |
| 3 | Functionalized scaffolds to enhance tissue regeneration显示文摘Tissue engineering scaffolds play a vital role in regenerative medicine.It not only provides a temporary 3-dimensional support during tissue repair,but also regulates the cell behavior,such as cell adhesion,proliferation and differentiation.In this review,we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nanocomposites of hydroxyapatite(HA)and bioactive glasses(BGs)with various biodegradable polymers.Furthermore,the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning,deposition and thermally induced phase separation is discussed.Moreover,bioactive molecules and surface properties of scaffolds are very important during tissue repair.Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed. | Baolin Guo Bo Lei Peng Li Peter X.Ma | 2015 | Regenerative Biomaterials2015，2，1： | 8 |
| 4 | Classification of cultivated Chinese medicinal plants based on fractal theory and gray level co-occurrence matrix textures显示文摘 | ZHENG Shudan ZHENG Jianghua SHI Minghui GUO Baolin SEN Bati SUN Zhiqun JIA Xiaoguang LI Xiaojin | 2014 | 遥感学报2014，18，4： | 5 |
| 5 | Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering显示文摘Conductive biomaterials based on conductive polymers,carbon nanomaterials,or conductive inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering,owing to the similar conductivity to human skin,good antioxidant and antibacterial activities,electrically controlled drug delivery,and photothermal effect.However,a review highlights the design and application of conductive biomaterials for wound healing and skin tissue engineering is lacking.In this review,the design and fabrication methods of conductive biomaterials with various structural forms including film,nanofiber,membrane,hydrogel,sponge,foam,and acellular dermal matrix for applications in wound healing and skin tissue engineering and the corresponding mechanism in promoting the healing process were summarized.The approaches that conductive biomaterials realize their great value in healing wounds via three main strategies(electrotherapy,wound dressing,and wound assessment)were reviewed.The application of conductive biomaterials as wound dressing when facing different wounds including acute wound and chronic wound(infected wound and diabetic wound)and for wound monitoring is discussed in detail.The challenges and perspectives in designing and developing multifunctional conductive biomaterials are proposed as well. | Rui Yu Hualei Zhang Baolin Guo | 2022 | Nano-Micro Letters2022，14，1： | 4 |
| 6 | Emerging hemostatic materials for non-compressible hemorrhage control显示文摘Non-compressible hemorrhage control is a big challenge in both civilian life and the battlefield,causing a majority of deaths among all traumatic injury mortalities.Unexpected non-compressible bleeding not only happens in pre-hospital situations but also leads to a high risk of death during surgical processes throughout in-hospital treatment.Hemostatic materials for pre-hospital treatment or surgical procedures for non-compressible hemorrhage control have drawn more and more attention in recent years and several commercialized products have been developed.However,these products have all shown non-negligible limitations and researchers are focusing on developing more effective hemostatic materials for non-compressible hemorrhage control.Different hemostatic strategies(physical,chemical and biological)have been proposed and different forms(sponges/foams,sealants/adhesives,microparticles/powders and platelet mimics)of hemostatic materials have been developed based on these strategies.A summary of the requirements,state-of-the-art studies and commercial products of non-compressible hemorrhage-control materials is provided in this review with particular attention on the advantages and limitations of their emerging forms,to give a clear understanding of the progress that has been made in this area and the promising directions for future generations. | Ruonan Dong Hualei Zhang Baolin Guo | 2022 | National Science Review2022，9，11： | 3 |
| 7 | Antibacterial biomaterials for skin wound dressing显示文摘Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human health.And bacterial contamination could significantly menace the wound healing process.Considering the sophisticated wound healing process,novel strategies for skin tissue engineering are focused on the integration of bioactive ingredients,antibacterial agents included,into biomaterials with different morphologies to improve cell behaviors and promote wound healing.However,a comprehensive review on antibacterial wound dressing to enhance wound healing has not been reported.In this review,various antibacterial biomaterials as wound dressings will be discussed.Different kinds of antibacterial agents,including antibiotics,nanoparticles(metal and metallic oxides,lightinduced antibacterial agents),cationic organic agents,and others,and their recent advances are summarized.Biomaterial selection and fabrication of biomaterials with different structures and forms,including films,hydrogel,electrospun nanofibers,sponge,foam and three-dimension(3D)printed scaffold for skin regeneration,are elaborated discussed.Current challenges and the future perspectives are presented in thismultidisciplinary field.We envision that this review will provide a general insight to the elegant design and further refinement of wound dressing. | Yuqing Liang Yongping Liang Hualei Zhang Baolin Guo | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，3： | 3 |
| 8 | Hybrid polymer biomaterials for bone tissue regeneration显示文摘Native tissues possess unparalleled physiochemical and biological functions, which can be attributed to their hybrid polymer composition and intrinsic bioactivity. However, there are also various concerns or limitations over the use of natural materials derived from animals or cadavers, including the potential immunogenicity, pathogen transmission, batch to batch consistence and mismatch in properties for various applications. Therefore, there is an increasing interest in developing degradable hybrid polymer biomaterials with controlled properties for highly efficient biomedical applications. There have been efforts to mimic the extracellular protein structure such as nanofibrous and composite scaffolds, to functionalize scaffold surface for improved cellular interaction, to incorporate controlled biomolecule release capacity to impart biological signaling, and to vary physical properties of scaffolds to regulate cellular behavior. In this review, we highlight the design and synthesis of degradable hybrid polymer biomaterials and focus on recent developments in osteoconductive, elastomeric, photoluminescent and electroactive hybrid polymers. The review further exemplifies their applications for bone tissue regeneration. | Bo Lei Baolin Guo Kunal J.Rambhia Peter X.Ma | 2019 | Frontiers of Medicine2019，13，2： | 3 |
| 9 | Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing显示文摘With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds,the development of new antibacterial and accelerated wound healing dressings has become a serious challenge.In order to solve this problem,we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan(CSG-PEG),methacrylamide dopamine(DMA)and zinc ion for disinfection of drug-resistant bacteria and promoting wound healing.The mechanical properties,rheological properties and morphology of hydrogels were characterized,and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility tests.These hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation model.In addition,it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus(MRSA).In the full-thickness skin defect model infected with MRSA,the wound closure ratio,thickness of granulation tissue,number of collagen deposition,regeneration of blood vessels and hair follicles were measured.The inflammation-related cytokines(CD68)and angiogenesis-related cytokines(CD31)expressed during skin regeneration were studied.All results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™Film,revealing that they have become promising alternative in the healing of infected wounds. | Yutong Yang Yongping Liang Jueying Chen Xianglong Duan Baolin Guo | 2022 | Bioactive Materials2022，7，2： | 3 |
| 10 | Injectable Self‑Healing Adhesive pH‑Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing显示文摘Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)are well-established therapeutics for gastrointestinal neoplasias,but complications after EMR/ESD,including bleeding and perforation,result in additional treatment morbidity and even threaten the lives of patients.Thus,designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge.Herein,a series of injectable pH-responsive selfhealing adhesive hydrogels based on acryloyl-6-aminocaproic acid(AA)and AA-g-N-hydroxysuccinimide(AA-NHS)were developed,and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model.The hydrogels showed a suitable gelation time,an autonomous and efficient self-healing capacity,hemostatic properties,and good biocompatibility.With the introduction of AA-NHS as a micro-cross-linker,the hydrogels exhibited enhanced adhesive strength.A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding.A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition,α-SMA expression,and blood vessel formation.These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment. | Jiahui He Zixi Zhang Yutong Yang Fenggang Ren Jipeng Li Shaojun Zhu Feng Ma Rongqian Wu Yi Lv Gang He Baolin Guo Dake Chu | 2021 | Nano-Micro Letters2021，13，5： | 1 |
| 11 | Insight into the microstructural evolution of anthracite during carbonization-graphitization process from the perspective of materialization显示文摘Materialization of coal is one of effective and clean pathways for its utilization. The microstructures of coal-based carbon materials have an important influence on their functional applications. Herein, the microstructural evolution of anthracite in the temperature range of 1000–2800 ℃ was systematically investigated to provide a guidance for the microstructural regulation of coal-based carbon materials.The results indicate that the microstructure of anthracite undergoes an important change during carbonization-graphitization process. As the temperature increases, aromatic layers in anthracite gradually transform into disordered graphite microcrystals and further grow into ordered graphite microcrystals, and then ordered graphite microcrystals are laterally linked to form pseudo-graphite phase and eventually transformed into highly ordered graphite-like sheets. In particular, 2000–2200 ℃ is a critical temperature region for the qualitative change of ordered graphite crystallites to pseudo-graphite phase,in which the relevant structural parameters including stacking height, crystallite lateral size and graphitization degree show a rapid increase. Moreover, both aromaticity and graphitization degree have a linear positive correlation with carbonization-graphitization temperature in a specific temperature range.Besides, after initial carbonization, some defect structures in anthracite such as aliphatic carbon and oxygen-containing functional groups are released in the form of gaseous low-molecular volatiles along with an increased pore structure, and the intermediates derived from minerals could facilitate the conversion of sp^(3) amorphous carbon to sp^(2) graphitic carbon. This work provides a valuable reference for the rational design of microstructure of coal-based carbon materials. | Huihui Zeng Baolin Xing Yijun Cao Bing Xu Lei Hou Hui Guo Song Cheng Guangxu Huang Chuanxiang Zhang Qi Sun | 2022 | International Journal of Mining Science and Technology2022，32，6： | 1 |
| 12 | Characterization and catalytic performance of TiO2 nanotubes-supported gold and copper particles显示文摘 | Zhu Baolin Guo Qi | 2006 | J Mol Catal A2006，249，12： | 1 |
| 13 | Brevicornin,a flavonal from Epimedium brivicornum显示文摘 | Guo Baolin | 1996 | Phytochemistry1996，41，3： | 1 |
| 14 | Preparation and properties of a pH / temperature-responsive carboxymethyl chitosan / poly (N-isopropylacrylamide)semi-IPN hydrogel for oral delivery of drugs 显示文摘 | Guo Baolin Gao Qingyu | 2007 | Carbohydrate Research2007，342，16： | 1 |
| 15 | Structural and Functional Design of Electrospun Nanofibers for Hemostasis and Wound Healing显示文摘Electrospun nanofibers have been extensively studied in the biomedical field,including the controlled release of drugs,bionics,cell scaffolds,hemostasis,wound healing,and tissue engineering because of their high porosity,large surface area-to-volume ratio,and programmable features.In recent years researchers have continuously broadened the structural design of electrospun nanofibers,which have evolved from one-dimensional to three-dimensional structures,in order to diversify their function.These properties enable nanofibers to structurally and functionally mimic natural extracellular matrix(ECM),thereby obtaining a favorable physiological microenvironment for both wound healing and hemostasis due to improved blood coagulation and concentration.A comprehensive review summarizing the recent research progress of the structural and functional design of electrospun nanofibers for hemostasis and wound healing,on the other hand,is lacking.This review summarizes electrospun nanofibers used for hemostasis and wound healing,with a focus on structural design and modification strategies.The wide application of electrospun nanofibers in hemostasis and wound healing is clarified using a special structural and innovative design for electrospinning.The advantages and limitations of electrospun nanofibers with various structural forms are also discussed,as are the main challenges and future development directions for the development of structurally specific electrospun nanofibers for hemostasis and wound healing. | Yutong Yang Yuzhang Du Jie Zhang Hualei Zhang Baolin Guo | 2022 | Advanced Fiber Materials2022，4，5： | 1 |
| 16 | Preparation and properties of a pH/temperature-responsive carboxymethyl chitosan/poly(犖-isopropylacrylamide)semi-IPN hydrogel for o-ral delivery of drugs显示文摘 | Guo Baolin Gao Qingyu | | 0，，16： | 1 |
| 17 | Fast quality control of herba epimedii by using fourier transform infrared spectroscopy显示文摘 | PEI Likuan SUN Suqin GUO Baolin | 2008 | Spectrochim Acta Part A2008，70，2： | 1 |
| 18 | Fast quality control of herb aepimedii by using fourier transform infrared spectroscopy显示文摘 | PEIL ikuan SUN Suqin GUO Baolin | 2008 | Spectrochim Acta Part A2008，70，： | 1 |
| 19 | Preparation and release profiles of pH/temperature-responsive carboxymethyl chitosan/P(2-(dimethylamino) ethyl methacrylate) semi-IPN amphoteric hydrogel显示文摘 | Baolin Guo Jinfang Yuan Li Yao | 2007 | Colloid & Polymer Science2007，285，6： | 1 |
| 20 | Degradable and electroactive hydrogels with tunable electricalconductivity and swelling behavior显示文摘 | Guo Baolin Anna Finne-Wistrand Ann-Christine Albertsson | 2011 | Chemistry of Matericals2011，23，5： | 1 |
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