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| 1 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044sx65wpcqnuqow6fuw.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 2 | C1q nephropathy in children: clinical characteristics and outcome显示文摘 | Vindya N. Gunasekara Neil J. Sebire Kjell Tullus | 2014 | Pediatric Nephrology2014，，： | 1 |
| 3 | Rahitrexed-a review of its pharmacological andproperties and clinical efficacy in management of advanced colorectal cancer 显示文摘 | NISHAN S GUNASEKARA DIANA F | 1998 | Drugs1998，55，3： | 1 |
| 4 | Comparison of abciximab with' high-dose' tirofiban in patients undergoing percutaneous coronary intervention 显示文摘 | Gunasekara AP Walters DL Aroney CN | 2006 | Int J Cardiol2006，109，1： | 1 |
| 5 | Zolmitriptan显示文摘 | Caroline M Spencer Nishan S Gunasekara Carol Hill s | 1999 | Drugs1999，58，2： | 1 |
| 6 | Zolmitriptan-a review of its use in migraine显示文摘 | Spencer CM Gunasekara NS Hills C | 1999 | Drugs1999，58，2： | 1 |
| 7 | Reframing the role of universities in the development of regional innovation systems 显示文摘 | CHRYS GUNASEKARA | 2006 | The Journal of Technology Transfer2006，31，1： | 1 |
| 8 | Ziprasidone:A review of its use in schizophrenia and schizoaffective disorder显示文摘 | Gunasekara NS Spencer CM Keating GM | 2002 | Drugs2002，，62： | 1 |
| 9 | Isosorbide 5-mononitrate: a review of a sustained-release formulation (Imdur) in stable angina peetorisM 显示文摘 | Gunasekara NS Noble S | 1999 | Drugs1999，57，2： | 1 |
| 10 | The generative and developmental roles of universities in regional innovation systems显示文摘 | GUNASEKARA C | 2006 | Science and Pub- lic Policy2006，33，2： | 1 |
| 11 | Sorption and desorption of naphthalene by soil organic matter: importance of aromatic and aliphatic components 显示文摘 | Gunasekara A S Xing B 2003 | 2003 | J Environ Qual2003，32，： | 1 |
| 12 | Sorption and desorption of naphthaleneby soil organic matter:importance of aromatic and aliphaticcomponents 显示文摘 | GUNASEKARA A S XING B | 2003 | Journal of Environmental Quality2003，32，1： | 1 |
| 13 | Zolmitriptan 显示文摘 | CAROLINE M SPENCER NISHAN S GUNASEKARA CAROL HILLS | 1999 | Drugs1999，58，2： | 1 |
| 14 | Sorption and desorption of naphthalene by soil organic matter:Importance of aromatic and aliphatic components显示文摘 | Gunasekara A S Xing B S | | 0，，1： | 1 |
| 15 | Environmental fate and toxicology of fipronil 显示文摘 | Gunasekara A S Truong T Goh K S | 2007 | Journal of Pesticide Science2007，32，3： | 1 |
| 16 | Paroxetine:An update of its pharmacology and therapeutic use in depression and a review of its use in other disorders显示文摘 | Gunasekara NS Noble S Benfield P | 1998 | Drugs1998，55，1： | 1 |
| 17 | Environmental fate and toxi- cology of fipronil显示文摘 | Gunasekara A S Truong T Goh K S | 2007 | Journal of Pesticide Science2007，32，3： | 1 |
| 18 | Ziprasidone:a review of its use in schizopherenia and schizoaffective disorder显示文摘 | Gunasekara NS Spencer CM Keating GM | 2002 | Drugs2002，62，8： | 1 |
| 19 | Sorption and desorption of naphthalene by soil organic matter:Importance of aromatic and aliphatic components显示文摘 | Gunasekara A S Xing B S | 2003 | Journal of Environmental Quality2003，32，1： | 1 |
| 20 | Refraining the Role of Universities in the Development of Regional Innovation Systerns 显示文摘 | Chrys Gunasekara | 2006 | The Journal of Technology Transfer2006，，31： | 1 |
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