3篇
您的检索式：作者名="GUIHUAN LI"
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| 1 | Propofol inhibits cells migration and invasion via HOTAIR/miR-93/HIF-1α-mediated lactate secretion in colon cancer显示文摘Propofol,a common intravenous anesthetic used in clinical,has been shown to regulate cells proliferation,inflammation,angiogenesis and metastasis as well as exerting anti-cancer effect in several different types of cancer.However,the functions and mechanisms of propofol in lactate secretion and invasion of cancer cells remain unknown.The primary aim of this study was to investigate the role of propofol in cells migration and invasion of colon cancer(CRC).Scratches assay,Transwell assay were used to detect colon cells migration and invasion.Realtime Quantitative Polymerase Chain Reaction(RT-qPCR),Western blotting were utilized to detect the expression of related molecules.Dual-luciferase assay was performed to identify transcriptional activity of target genes,RNA pulldown assay was used to confirm the interactions of RNAs.Results indicated that propofol inhibited cell migration and invasion through suppressing lactic acid production in CRC.Moreover,propofol reduced lactic acid production by down-regulating the expression of hypoxia inducible factor-1α(HIF-1α)and monocarboxylate transporter 4(MCT4).In addition,propofol inhibited the expression of HIF-1αand cells migration/invasion via suppressing the interaction of HOX transcript antisense RNA(HOTAIR)with miR-93.The present study indicated that propofol inhibited colon cancer cell migration and invasion by reducing lactic acid production and the expression of HIF-1αand MCT4 via HOTAIR/miR-93 axis.These data may provide potential metabolic targets for CRC treatment. | RUONAN GU WENJING GUO WENYANG WANG GUIHUAN LI XIAOJU LAI ZHIBIN HUANG WANLU ZHAO ZHICONGWU HUA CHEN WENYANG LUO FANGYIN ZENG FAN DENG | 2021 | BIOCELL2021，45，6： | 0 |
| 2 | China connection of the Arnold Arboretum of Harvard University显示文摘The Arnold Arboretum of Harvard University,located in the Jamaica Plain and Roslindale sections of Boston,is famous for its collection and scientific study of ligneous species in North America and eastern Asia.In the 140-year history of the Arboretum(established in 1872),it has built a strong connection with Chinese botany and Chinese botanists,which can be traced back to over a hundred years ago. | Guihuan Luo Ang Li Ming Li | 2012 | Protein & Cell2012，3，2： | 0 |
| 3 | Maturation of induced pluripotent stem cell-derived cardiomyocytes and its therapeutic effect on myocardial infarction in mouse显示文摘Induced pluripotent stem cell-derived cardiomyocytes(iPSC-CMs)have an irreplaceable role in the treatment of myocardial infarction(MI),which can be injected into the transplanted area with new cardiomyocytes(Cardiomyocytes,CMs),and improve myocardial function.However,the immaturity of the structure and function of iPSC-CMs is the main bottleneck at present.Since collagen participates in the formation of extracellular matrix(ECM),we synthesized nano colloidal gelatin(Gel)with collagen as the main component,and confirmed that the biomaterial has good biocompatibility and is suitable for cellular in vitro growth.Subsequently,we combined the PI3K/AKT/mTOR pathway inhibitor BEZ-235 with Gel and found that the two combined increased the sarcomere length and action potential amplitude(APA)of iPSC-CMs,and improved the Ca^(2+)processing ability,the maturation of mitochondrial morphological structure and metabolic function.Not only that,Gel can also prolong the retention rate of iPSC-CMs in the myocardium and increase the expression of Cx43 and angiogenesis in the transplanted area of mature iPSC-CMs,which also provides a reliable basis for the subsequent treatment of mature iPSC-CMs. | Peng Wu Xiyalatu Sai Zhetao Li Xing Ye Li Jin Guihuan Liu Ge Li Pingzhen Yang Mingyi Zhao Shuoji Zhu Nanbo Liu Ping Zhu | 2023 | Bioactive Materials2023，，2： | 0 |
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