|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Insomnia is associated with increased mortality in patients with first-ever stroke:a 6-year follow-up in a Chinese cohort study显示文摘Objective Insomnia is a highly prevalent disorder among patients suffering from stroke.The association between insomnia and stroke mortality is less studied,particularly using the latest diagnostic criteria.The current study examined the relationship between insomnia and mortality among patients with first-evonal hazard models were used to calculate HRs for stroke er stroke in China.Methods Patients with acute cerebrovascular diseases(stroke)were recruited from 56 hospitals in China's Mainland.Insomnia was defined as difficulty falling asleep,or difficulty staying asleep or waking up early,for at least two consecutive visits.Demographic data,medical history and clinical data were collected.Four follow-up visits occurred within the first year after stroke,and the last follow-up call was conducted 6 years later.Cox proportional hazard models were used to calculate HRs for stroke mortality.results Insomnia was reported by 38.4%(489/1273)of patients at baseline.During the 6 years of follow-up,after adjusting for all confounders,insomnia was found to be associated with increased mortality(HR=1.66,95%CI 1.10 to 2.48).Old age(HR=1.08,95%CI 1.06 to 1.10),stroke recurrence in the first year of follow-up(HR=2.53,95%CI 1.48 to 4.31)and stroke survivors with hypertension(HR=1.62,95%CI 1.04 to 2.53)had substantially higher risk of mortality.Conclusions Besides old age,stroke recurrence in the first year of follow-up and hypertension,insomnia is associated with increased risk of mortality in patients with first-ever stroke in China.More studies about prompt and efficient interventions for insomnia are expected in the future.Trial registration number rctn62169508. | Li-Jun Li Yang Yang Bo-Yuan Guan Qi Chen An-Xin Wang Yong-Jun Wang Ning Zhang Chun-Xue Wang | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 2 | Prognostic values of serum cystatin C and β2 microglobulin, urinary β2 microglobulin and N-acetyl-β-D-glucosaminidase in early acute renal failure after liver transplantation显示文摘在肝移植以后的背景尖锐肾的失败(ARF ) 与高死亡和病态被联系。早治疗学或预防的干预被早有效的预示的因素的缺乏妨碍。最近的研究显示那浆液 cystatin 铺平 C 和 2-microglobulin (132 MG ) 象一样尿 2 MG 和 N 乙酰 --D- glucosaminidase (唠叨) 将与早、温和的肾的缺陷在病人增加。在这研究,这些因素在接受了 orthotopic 肝移植( OLT )的病人在不同阶段期间被检测,并且他们在 OLT 以后预言早 ARF 的可行性也是 analyzed.Methods 没有,接待了的有正常的血脲氮(甜面包)和浆液 creatinine ( SCr )的六十个病人修改了骑在背肩上的肝移植veno静脉绕过有希望地被学习。血样品为浆液 2 MG (n=60 ) 的决心从病人被拉, SCr (n=60 ) 和在跟随 5 间隔的浆液 Cystatin C (n=39 ) :在操作前(到) ,在 anhepatic 阶段(T1 ) 前的 20 分钟,在 anhepatic (T2 ) 的 25 分钟,在 repeffusion (T3 ) 以后并且在操作(T4 ) 的结束的 60 分钟。尿 2 MG (n=-60 ) 并且唠叨(n=60 ) 也在跟随 3 间隔被检验:在操作前(到) ,在灌注(T3 ) 以后并且在操作(T4 ) 的结束的 60 分钟。根据 Rimola 在在操作以后的 24 个小时的 ARF 的 A 标准,所有病人被划分成二个组:ARF 组和 non-ARF 组。数据统计上被分析评估在六十个盒子中的十个显示出的 operation.Results 前与正常 SCr 和甜面包在病人在肝移植以后为早 ARF 认为这些因素是预示的因素的 feasibiliy ARF (16.7%) 。逻辑回归分析证明浆液的层次并且尿在操作前的 2 MG 以及浆液 cystatin C 在肝移植以后与早 ARF 被相关( P < 0.05 ),当仅仅浆液 cystatin 铺平时,在操作的结束的 C 和 Cr 与早 ARF 相关( P < 0.05 , P < 0.01 )在肝移植以后。浆液 2 MG, Cystatin C, SCr 并且尿在 ARF 组的 2 个 MG 层次在 non-ARF 组比那更多高(P < 0.05, P < 0.01 ) 。浆液 cystatin C 的正确、假的预兆的积极比率之间有重要差别,浆液并且尿在操作前的 2 个 MG 层次( P < 0.05 , P < 0.01 ),当仅仅 SCr 在手术的结束显示出这些组之间的重要差别时( P < 0.01 )结果揭示了的 .Conclusions 在在手术,和那肝移植前表明了正常 SCr 和甜面包的那些病人之中有潜在的肾的损坏,这能加重这损坏并且引起 ARF 。这里,我们提供了浆液 Cystatin C 的预示的价值, 2 MG,尿 2 MG 并且在肝移植以后与早尖锐的肾的失败在病人唠叨。 | HEI Zi-qing LI Xiao-yun SHEN Ning PANG Hong-yu ZHOU Shao-li GUAN Jian-qiang | 2008 | Chinese Medical Journal2008，，14： | 26 |
| 3 | Safety and efficacy of ciprofol vs.propofol for sedation in intensive care unit patients with mechanical ventilation:a multi-center,open label,randomized,phase 2 trial显示文摘Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416. | Yongjun Liu Xiangyou Yu Duming Zhu Jun Zeng Qinhan Lin Bin Zang Chuanxi Chen Ning Liu Xiao Liu Wei Gao Xiangdong Guan | 2022 | Chinese Medical Journal2022，，9： | 19 |
| 4 | miR-27b inhibits gastric cancer metastasis by targeting NR2F2显示文摘增加的注意在癌症过程集中于 miRNAs 的下面规定。原子受体亚科 2 (NR2F2,也作为 COUP-TFII 知道) 涉及癌症的许多类型的发展,但是它在胃的癌症的角色留下逃犯。在这个实验, oncomine 和 Kaplan-meier 数据库表明 NR2F2 在胃的癌症是起来调整的并且高 NR2F2 表示贡献了差的幸存。MicroRNA-27b 被指向并且由在人的胃的癌症纸巾和房间的 NR2F2 下面调整。miR-27b 的宫外的表示在 vitro 并且在 vivo 禁止了胃的癌症房间增长和肿瘤生长。试金建议 miR-27b 的 overexpression 能支持 MGC-803 房间移植和侵略并且延迟他们的转移到肝。另外, miR-27b 的下面规定在 vitro 提高了 GES-1 房间增长和转移。这些调查结果表明 miR-27b 为改进病人是在胃的癌症和 biomarker 的肿瘤 suppressor 幸存。 | Qingzhao Feng Xionglin Wu Fuchao Li Beibei Ning Xiaofeng Lu Yin Zhang Ying Pan Wenxian Guan | 2017 | Protein & Cell2017，8，2： | 16 |
| 5 | Persistent depression is a predictor of quality of life in stroke survivors: results from a 5-year follow-up study of a Chinese cohort显示文摘Background:Whether the time course of post-stroke depression (PSD) can be used to predict the quality of life (QoL) of patients with late-stage stroke remains unclear,this study investigated whether persistent depression at 1 year after stroke predicts QoL at 5 years following stroke.Methods:We analyzed the demographic and clinical data of patients with stroke in 56 hospitals across China that participated in the Prospective Cohort Study on the Incidence and Outcome of Patients with PSD in China Study.Follow-up assessments were performed at the following time points after stroke:in person,2 weeks,3 months,6 months,and 1 year;by telephone,5 years.National Institutes of Health Stroke Scale (NIHSS) score on admission,recurrence,disability,depression,QoL,and chronic complications were recorded.Depression was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders.QoL was measured using short form-12 (SF-12).Multivariable ordinal logistic regression analysis was used to identify factors that independently affected the physical component summary (PCS) and mental component summary (MCS) scores of the SF-12.Results:Of the 801 patients evaluated in this study,80 had persistent depression.The multivariable regression analysis of data obtained at 5 years showed that persistent depression at 1 year (odds ratio [OR]:0.48;95% confidence interval [CI]:0.29-0.81) and disability at 5 years (OR:0.34;95% CI:0.23-0.49) were associated with poor MCS scores at 5 years.Old age,a high NIHSS score on admission,disability at 5 years,and stroke recurrence within 5 years were associated with poor PCS scores at the 5-year follow-up.Conclusions:Persistent depression at the 1-year follow-up could predict poor MCS scores at the 5-year follow-up.The development of interventional strategies targeting post-stroke patients with persistent depression is warranted. | Li-Jun Li Xiao-Mei Yao Bo-Yuan Guan Qi Chen Ning Zhang Chun-Xue Wang | 2019 | Chinese Medical Journal2019，，18： | 11 |
| 6 | Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration显示文摘The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property.Bone marrow stem cells(BMSCs)derived exosomes(Exos)contain multiple biosignal molecules and have been demonstrated to exhibit immunomodulatory functions.Herein,we develop a BMSC-derived Exos-functionalized implant to accelerate bone integration by immunoregulation.BMSC-derived Exos were reversibly incorporated on tannic acid(TA)modified sulfonated polyetheretherketone(SPEEK)via the strong interaction of TA with biomacromolecules.The slowly released Exos from SPEEK can be phagocytosed by co-cultured cells,which could efficiently improve the biocompatibilities of SPEEK.In vitro results showed the Exos loaded SPEEK promoted macrophage M2 polarization via the NF-κB pathway to enhance BMSCs osteogenic differentiation.Further in vivo rat air-pouch model and rat femoral drilling model assessment of Exos loaded SPEEK revealed efficient macrophage M2 polarization,desirable new bone formation,and satisfactory osseointegration.Thus,BMSC-derived Exos-functionalized implant exerted osteoimmunomodulation effect to promote osteogenesis. | Lei Fan Pengfei Guan Cairong Xiao Huiquan Wen Qiyou Wang Can Liu Yian Luo Limin Ma Guoxin Tan Peng Yu Lei Zhou Chengyun Ning | 2021 | Bioactive Materials2021，6，9： | 11 |
| 7 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 8 | A low-noise fully-differential CMOS preamplifier for neural recording applications显示文摘A fully-differential bandpass CMOS preamplifier for extracellular neural recording is presented in this paper.The capacitive-coupled and capacitive-feedback topology is adopted.We describe the main noise sources of the proposed preamplifier and discuss the methods for achieving the lowest input-referred noise.The preamplifier has a midband gain of 43 dB and a DC gain of 0.The-3 dB upper cut-off frequency of the preamplifier is 6.8 kHz.The lower cut-off frequency can be adjusted for amplifying the field or action potentials located in different bands.It has an input-referred noise of 3.36 μVrms integrated from 1 Hz to 6.8 kHz for recording the local field potentials(LFPs)and the mixed neural spikes with a power dissipation of 24.75 μW from 3.3 V supply.When the passband is configured as 100 Hz-6.8 kHz for only recording spikes,the noise is measured to be 3.01 μVrms.The 0.115 mm2 prototype chip is designed and fabricated in 0.35-μm N-well CMOS(complementary metal oxide semiconductor)2P4M process. | ZHANG Xu PEI WeiHua HUANG BeiJu GUAN Ning CHEN HongDa | 2012 | Science China(Information Sciences)2012，55，2： | 11 |
| 9 | Association between the presence of H pylori in the liver and hepatocellular carcinoma: A meta-analysis显示文摘AIM: To evaluate the arguments for and against the possible roles of H pylori in hepatocellular carcinoma (HCC). METHODS: We performed a systematic review of all relevant studies published in the literature. A total of 103 clinical trials and reports were identified, but only 10 trials qualified under our selection criteria. A meta-analysis was carried out by a biostatistician according to the Cochrane Reviewers’ Handbook recommended by The Cochrane Collaboration.RESULTS: Nine case-control studies and one retrospective cross sectional study were included in the final analysis. Overall the prevalence of H pylori infection was 53.3% (129 of 242) in cases and 10.4% (29 of 280) in controls, and the summary odds ratio for the association of H pylori infection with the risk for HCC (using the fixed-effects model, which accounted for the homogeneity across the 10 studies) was determined to be 13.63 (95% CI, 7.90-23.49).CONCLUSION: Our analysis showed a positive association between H pylori infection and the risk of HCC, with an indication of possible publication bias and possible confounders due to study designs that showed results of less pronounced associations. | Shi-Ying Xuan Yong-Ning Xin An-Jin Chen Quan-Jiang Dong Xin Qiang Ning Li Ming-Hua Zheng Hua-Shi Guan | 2008 | World Journal of Gastroenterology2008，14，2： | 10 |
| 10 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 11 | Ecology and social system of northern gibbons living in cold seasonal forests显示文摘Gibbons in China represent the northernmost margin of present day gibbon species distribution(around N25°). Compared to tropical habitats, northern gibbon habitats are characterized by low temperatures and remarkable seasonal variation in fruit abundance.How gibbons adapt to their cold and seasonal habitats and what ecological factors affect their sociality are key questions for understanding their ecology and social system evolution, the elucidation of which will contribute to the conservation of these special populations/species. According to preliminary short-term studies, northern gibbons consume more leaves and use larger home ranges than tropical gibbons. Interestingly, some Nomascus groups consist of more than one adult female. However,these preliminary results are not well understood or incorporated into current socio-ecological theories regarding gibbon species. To better understand northern gibbons, our team has systematically studied three habituated groups of Nomascus concolor, three groups of N. nasutus, and two habituated groups of Hoolock tianxing since 2002. In this paper,we stress the challenges facing gibbons living in northern habitats and summarize their behavioral adaptations to their harsh environments. We also describe the northern gibbon social system and discuss the potential relationships between their ecology and sociality. Finally, we highlight future research questions related to northern gibbons in China. | Zhen-Hua Guan Chang-Yong Ma Han-Lan Fei Bei Huang Wen-He Ning Qing-Yong Ni Xue-Long Jiang Peng-Fei Fan | 2018 | Zoological Research2018，39，4： | 8 |
| 12 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 13 | Important role of a LAL regulator Sta R in the staurosporine biosynthesis and high-production of Streptomyces fradiae CGMCC 4.576显示文摘Staurosporine, belonging to indolocarbazole compounds, is regarded as an excellent lead compound for synthesizing antitumor agents as a potent inhibitor against various protein kinases. In this study, two separate clusters(cluster A and cluster B),corresponding to biosyntheses of K-252 c(staurosporine aglycone) and sugar moiety, were identified in Streptomyces fradiae CGMCC 4.576 and heterologously expressed in Streptomyces coelicolor M1146 separately or together. Sta R, a cluster-situated LAL family regulator, activates staurosporine biosynthesis by binding to the promoter regions of sta O-sta C and sta G-sta N. The conserved sequences GGGGG and GCGCG were found through gradually truncating promoters of sta O and sta G, and further determined by mutational experiments. Overexpression of sta R with the supplementation of 0.01 g L^–1 Fe SO4 increased staurosporine production to 5.2-fold compared with that of the parental strain Streptomyces fradiae CGMCC 4.576 in GYM medium. Our results provided an approach for improvement of staurosporine production mediated by a positive regulator and established the basis for dissecting the regulatory mechanisms of other indolocarbazole compounds with clinical application value. | Hanye Guan Yue Li Jiazhen Zheng Ning Liu Jihui Zhang Huarong Tan | 2019 | Science China(Life Sciences)2019，62，12： | 6 |
| 14 | False data injection attacks against smart grid state estimation:Construction, detection and defense显示文摘As a typical representative of the so-called cyber-physical system,smart grid reveals its high efficiency,robustness and reliability compared with conventional power grid.However,due to the deep integration of electrical components and computinginformation in cyber space,smart grid is vulnerable to malicious attacks,especially for a type of attacks named false data injection attacks(FDIAs).FDIAs are capable of tampering meter measurements and affecting the results of state estimation stealthily,which severely threat the security of smart grid.Due to the significantinfluence of FDIAs on smart grid,the research related to FDIAs has received considerable attention over the past decade.This paper aims to summarize recent advances in FDIAs against smart grid state estimation,especially from the aspects of background materials,construction methods,detection and defense strategies.Moreover,future research directions are discussed and outlined by analyzing existing results.It is expected that through the review of FDIAs,the vulnerabilities of smart grid to malicious attacks can be further revealed and more attention can be devoted to the detection and defense of cyber-physical attacks against smart grid. | ZHANG Meng SHEN Chao HE Ning HAN SiCong LI Qi WANG Qian GUAN XiaoHong | 2019 | Science China(Technological Sciences)2019，62，12： | 6 |
| 15 | Evolution of secondary phase particles during deformation of Al-5Ti-1B master alloy and their effect on α-Al grain refinement显示文摘Addition of Al-5Ti-1B alloy to molten aluminum alloys can refine α-Al grains effectively and thereby improve their strength and toughness. TiAl_3 and TiB_2 in Al-5Ti-1B alloy are the main secondary-phase particles for refinement, while the understanding on the effect of their sizes on α-Al grain refinement continues to be fragmented. Therefore, Al-5Ti-1B alloys with various sizes and morphologies of the secondary-phase particles were prepared by equal channel angular pressing(ECAP). Evolution of the secondary-phase particles during ECAP process and their impact on α-Al grain refinement were studied by X-ray diffraction and scanning electron microscope(SEM). Results show that during the ECAP process, micro-cracks firstly appeared inside TiAl_3 particles and then gradually expanded, which resulted in continuous refinement of TiAl_3 particles. In addition, micro-distribution uniformity of TiB_2 particles was improved due to the impingement of TiAl_3 particles to TiB_2 clusters during deformation. Excessively large sizes of TiAl_3 particles would reduce the number of effective heterogeneous nucleus and thus resulted in poor grain refinement effectiveness. Moreover, excessively small TiAl_3 particles would reduce inhibitory factors for grain growth Q and weaken grain refinement effectiveness. Therefore, an optimal size range of 18-22 μm for TiAl_3 particles was suggested. | Hong Yu Ning Wang Renguo Guan Di Tie Zheng Li Yanan An Yang Zhang | 2018 | Journal of Materials Science & Technology2018，34，12： | 6 |
| 16 | Osteogenic fate of hypertrophic chondrocytes显示文摘 | Guan Yang Liang Zhu Ning Hou Yu Lan Xi-Mei Wu Bin Zhou Yan Teng Xiao Yang | 2014 | Cell Research2014，24，10： | 6 |
| 17 | Folfox4 regimen administered through combined hepatic arterial and systemic infusion for treatment of colorectal cancer with unresectable liver metastases显示文摘 | GUAN Mei CHEN Shu-chang Y1NG Hong-yan ZHAO Lin LI Xiao-yuan ZHOU Jian-feng SHAO Ya-juan YANG Xian-da LIN Yi NING Xiao-hong BAI Chun-mei | 2012 | Chinese Medical Journal2012，，20： | 5 |
| 18 | Primary obturator foramen pregnancy: a case report and review of literature显示文摘 | LIN Jing-xian LIU Qi JU Yan GUAN Qun WU Yuan-zhe ZHENG Ning | 2008 | Chinese Medical Journal2008，，14： | 5 |
| 19 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Gastric Cancer Patients显示文摘Purpose Malnutrition is severe among gastric cancer patients in China. While the Patient-Generated Subjective Global Assessment (PG-SGA) is a widely used nutritional assessment tool, the validation for Chinese patients with gastric cancer has not been performed yet. The aim of this research is to validate the Chinese version of the PGSGA in Chinese gastric cancer patients by conducting analyses of nutrition screening and assessment data. Methods Two thousand consecutive adult patients with gastric cancer were included in this observational, cross-sectional study in several tertiary hospitals in China. A survey was made among those patients, which included several questionnaires and some anthropometric parameters. We calculated the parameters to validate the use of PG-SGA categorizing the nutritional status of gastric cancer patients. Then we performed statistical analysis to evaluate the internal consistency, external consistency, and construct validity. Results This study verified the ability of the PG-SGA to differentiate gastric cancer patients into different nutritional groups. The confirmatory factor analysis verified the original four-factor structure of the PG-SGA. The internal and external consistency was measured by a concordance analysis which showed an intraclass correlation coefficients (ICC) of 0.987. The correlations of the Box 4 score with the Karnofsky performance status score demonstrated alternative form validity with good external consistency (Pearson, r = 0.643, P < 0.001). All three anthropometric dimensions of the PG-SGA were supported by principal component analysis. Spearman correlations (P < 0.001) were significant in the majority of tests. Conclusion The Chinese version of the PG-SGA is a valid tool to access the patients’ nutritional status for Chinese gastric patients. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2018 | Journal of Nutritional Oncology2018，3，4： | 5 |
| 20 | Change patterns of oncomelanid snail burden in areas within the Yangtze River drainage after the three gorges dam operated显示文摘Background:An'integrated control'strategy has been implemented within seven provinces at highest risk for schistosomiasis along Yangtze River in Peoples'Republic of China(P.R.China)since 2004.Since O ncom elania hupensis is the only intermediate host of the blood fluke(Schistosom a japonicum),controlling the distribution of snails is considered an essential and effeaive way to reduce the risk of schistosomiasis infection.The study aimed to determine the snail area burden and annual trend among provinces with potential risk for schistosomiasis along the Yangtze River,above and below the Three Gorges Dam(TGD).Methods:This retrospective study utilized data previously collected from the National Parasitic Diseases Control Information Management System(NPDCIMS)on annual snail surveys from 2009 to 2017.Descriptive statistics were performed for analyzing the snail burden by provinces,counties,type of environmental location and year,and mapping was conducted to present the snails distribution.Results:From 2009 to 2017,the total snail infested area decreased by 4.22%,from 372253 hm^2 to 356553 hm^2 within the seven high risk provinces.The majority of snails were found in the marshland and lake regions,outside of control embankments.The total snail burden trend remained relatively stable in upstream regions above the TGD from 2010 to 2015,while the trend decreased within downstream regions during this period.In 2016 and 2017,the total snail burden trend increased in both upstream and downstream provinces,however,upstream saw a larger increase.From 2009 to 2017,there were a total of 5990 hm^2 of newly developed snail areas in the seven study provinces and the majority were concentrated in regions below the TGD,accounting for 5610 hm^2(93.70%).Conclusions:There has been a decline in total snail counts from 2009 to 2017.Meanwhile,new snail breeding areas were formed mainly within provinces downstream the TGD due to spread of snails,indicated that the oncomelanid snail would be difficult to completely eliminate.We suggest that the national schistosomiasis integrated control strategy,including mollusciding and environmental modification,will need to be enhanced significantly going forward to achieve a greater reduaion in snail burden and ultimately to achieve elimination. | Si-Min Dai Jeffrey Edwards Zhou Guan Shan Lv Shi-Zhu Li Li-Juan Zhang Jun Feng Ning Feng Xiao-Nong Zhou Jing Xu | 2019 | Infectious Diseases of Poverty2019，8，3： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员