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| 1 | 内脏脂肪组织通过产生骨桥蛋白调控成纤维细胞衰老促进心脏衰老显示文摘老化通过增加包括骨桥蛋白(osteopontin,OPN)在内的细胞外基质(extracellular matrix,ECM)蛋白的沉积引起心脏结构和功能改变进而导致进行性间质纤维化。虽然已知OPN参与各种病理状况,但其在心肌衰老中的作用仍不清楚。 | Sawaki D Czibik G Pini M Ternacle J Suffee N Mercedes R Marcelin G Surenaud M Marcos E Gual P Clément K Hue S Adnot S Hatem SN Tsuchimochi I Yoshimitsu T Hénégar C Derumeaux G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，3： | 14 |
| 2 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 3 | Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes显示文摘 | Bouzakri K Roques M Gual P | | 0，，： | 1 |
| 4 | Self-esteem, personality, and eating disorders: Baseline assessment of a prospective population-based cohort 显示文摘 | GUAL P PEREZ-GASPAR M MARTINEZ-GONZALEZ MA | 2002 | Int J Eat Disord2002，31，3： | 1 |
| 5 | Determination of residual chlorine in greywater using o-tolidine显示文摘 | MARCH J G GUAL M SIMONET B M | 2002 | Talanta2002，58，： | 1 |
| 6 | Reduced activation of phosphatidylinositol-8 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes 显示文摘 | BOUZAKRI K ROQUES M GUAL P | 2003 | Diabetes2003，52，6： | 1 |
| 7 | Bridging Ecological and Social Systems Coevolution: A Review and Proposal 显示文摘 | Gual M Norgaard R | 2010 | Ecological Economics2010，69，： | 1 |
| 8 | Determination of re- sidual chlorine in greywater using o tolidine显示文摘 | MARCH J G M GUAL B M S | 2002 | Ta- lanta2002，28，5： | 1 |
| 9 | An integrated assessment of the feed-in tariff system in Spain显示文摘 | Del Rio P Gual M A | 2007 | Energy Policy2007，35，2： | 1 |
| 10 | Cross-talk between the proto-oncogenes Met and Ron显示文摘 | Follenzi A Bakovic S Gual P Stella M C Longati P Comoglio P M | 2000 | Oncogene2000，19，： | 1 |
| 11 | C31-I/HeJ mice carrying a toll- like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet 显示文摘 | Poggi M Bastelica D Gual P | 2007 | Diabetologia2007，50，6： | 1 |
| 12 | C3H/HeJmice carrying a Toll-likereceptor 4 mutation are protected against the development of insulinresistance in white adipose tissue in response to a high-fat diet显示文摘 | Poggi M Bastelica D Gual P | 2007 | Di-abetologia2007，50，6： | 1 |
| 13 | A multipole galerkin boundary element method for acoustics显示文摘 | FISCHER M GAUGER U GUAL L | 2004 | Eng Anal Boun Elem2004，28，： | 1 |
| 14 | Studies on chlorination of greywater显示文摘 | March J G Gual M | 2009 | Desalination2009，249，1： | 1 |
| 15 | Breakpoint chlorination curves of greywater显示文摘 | March J G Gual M | 2007 | Water Environment Research2007，79，8： | 1 |
| 16 | A kinetic model for chlorine consumption in grey water显示文摘 | J G March M Gual J Ramonell | 2005 | Desalination2005，，181： | 1 |
| 17 | Monitoring of an indoor pilot plant for osmosis rejection and grey water reuse to flush toilets in a hotel显示文摘 | Gual M MoiaA March G J | 2008 | Desali- nation2008，219，8： | 1 |
| 18 | Kinetic model for chlorine consumption in grey water 显示文摘 | MARCH J G GUAL M RAMONELL A J | 2005 | Desalination2005，181，： | 1 |
| 19 | C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet显示文摘 | Poggi M Bastelica D Gual P | 2007 | Diabetologia2007，50，6： | 1 |
| 20 | C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet显示文摘 | Poggi M Bastelica D Gual P | 2007 | Diabetologia2007，50，6： | 1 |
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