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| 1 | Dynamics of firing patterns,synchronization and resonances in neuronal electrical activities:experiments and analysis显示文摘在 neuronal 的动力学的试验性、理论的学习的最近的进展电的开火活动被考察。第一, neuronal 的一些试验性的现象不规则的开火模式,特别混乱、随机的开火的模式,被介绍,并且实际非线性的时间分析方法被介绍及时区分确定、随机的机制系列。第二,也就是,在一个单个神经原的电的开火的活动的动力学被担心为为发射模式的转变的各种各样的爆炸模式,一个参数或二参数的分叉分析的分类和机制的快慢动力学分析,和发射活动的随机的动力学(随机并且连贯回声,多重的整数和另外的开火的模式由噪音导致了,等等)。第三,有电、化学的触处的联合神经原的同步的不同类型被讨论。因为噪音和时间延期在神经系统是不可避免的,它被发现延期可以导致或提高发射联合神经原的模式的同步和变化的那噪音和时间。在联合 neuronal 网络的导致噪音的回声和空间与时间的模式也被表明。最后,一些前景为未来研究被介绍。在后果,非线性的动力学的想法和方法具有在动态进程的探索和神经系统的生理的函数的大意义。 | Qishao Lu Huaguang Gu Zhuoqin Yang Xia Shi Lixia Duan Yanhong Zheng | 2008 | Acta Mechanica Sinica2008，24，6： | 14 |
| 2 | Potassium-induced bifurcations and chaos of firing patterns observed from biological experiment on a neural pacemaker显示文摘Changes of neural firing patterns and transitions between firing patterns induced by the introduction of external stimulation or adjustment of biological parameter have been demonstrated to play key roles in information coding.In this paper,bifurcation processes of bursting patterns were observed from an experimental neural pacemaker,through the adjustment of potassium parameter including ion concentration and calcium-dependent channel conductance.The adjustment of calcium-dependent potassium channel conductance was achieved by changing the extracellular tetraethylammonium concentration.The deterministic dynamics of chaotic bursting patterns induced by period-doubling bifurcation and intermittency,and lying between two periodic bursting patterns in a period-adding bifurcation process was investigated with a nonlinear prediction method.The bifurcations included period-doubling and period-adding bifurcations of bursting patterns.The experimental bifurcations and chaos closely matched those previously simulated in the theoretical neuronal model by adjusting potassium parameter,which demonstrated the simulation results of the theoretical model.The experimental results indicate that the potassium concentration and conductance of calcium-dependent potassium channel can induce bifurcations of the neural firing patterns.The potential role of these bifurcation structures in neural information coding mechanism is discussed. | GU HuaGuang CHEN ShengGen | 2014 | Science China(Technological Sciences)2014，57，5： | 11 |
| 3 | Stochastic dynamics of conduction failure of action potential along nerve fiber with Hopf bifurcation显示文摘Action potentials can be induced by external electronic impulsive stimulations applied at one end of the unmyelinated fibers(C-fibers), while some action potentials fail to conduct to the other end of the fiber when the stimulation frequency becomes high. Such a phenomenon is called as conduction failure, which was observed in the biological experiments and related to the painful diabetic neuropathy, inflammation, and trauma in the previous studies. On-off firing pattern was recorded from the fiber when conduction failure happened. In the present study, the diffusion Hodgkin-Huxley(HH) model with resting state near a Hopf bifurcation is adopted to simulate the experimental observations. When the periodic electrical pulses with high frequency are applied to one end of the fiber described by the deterministic HH model, conduction failure and the corresponding firing patterns different from the on-off firing pattern are simulated. When noise is introduced to form the stochastic HH model, the firing pattern corresponding to conduction failure becomes the on-off firing pattern, which is characterised by transition behaviors between on-phase(continuous action potentials) and off-phase(a long quiescent state) and large variations in the durations of both phases. Furthermore, the increase of potassium conductance can enhance the conduction failure degree, which closely matches those observed in the experiment and is suggested to be related to the reduction of pain signals. The results show that noise is an important factor to evoke the on-off firing pattern, reveal the functional capability in the pain signals propagation along C-fiber,and present a possible measure for the treatment of chronic pain. | ZHANG XinJing GU HuaGuang GUAN LiNan | 2019 | Science China(Technological Sciences)2019，62，9： | 2 |
| 4 | Identifying type I excitability using dynamics of stochastic neural firing patterns显示文摘 | Bing Jia Huaguang Gu | 2012 | Cognitive Neurodynamics2012，，6： | 1 |
| 5 | The nonlinear mechanism for the same responses of neuronal bursting to opposite self-feedback modulations of autapse显示文摘In the traditional viewpoint,inhibitory and excitatory effects always induce opposite responses.In the present study,the enhanced bursting activities induced by excitatory autapses,which are consistent with the recent experimental observations,and those induced by inhibitory autapses,which is a paradoxical phenomenon,were simulated using the Chay model.The same bifurcations and different ionic currents for the same responses were acquired with fast-slow variable dissection and current decomposition,respectively.As the inhibitory or excitatory autaptic conductance increased,the ending phase of the burst related to a homoclinic bifurcation of the fast subsystem changed to widen the burst duration to contain more spikes,which was induced by an elevated minimal potential(V_(min)) of spiking of the fast subsystem.Larger inhibitory and excitatory autaptic conductances induced smaller and larger maximal potentials(V_(max)) of spiking,respectively.During the downstroke,a weaker potassium current induced by the smaller V_(max) played a dominant role for the inhibitory autapse,and the stronger potassium current induced by the larger V_(max) became weaker due to the opposite autaptic current of the excitatory autapse,which induced the V_(min) elevated.The results present the nonlinear and biophysical mechanisms of the same responses to opposite effects,which extends nonlinear dynamics knowledge and provides potential modulation measures for the nervous system. | LI YuYe GU HuaGuang JIA Bing DING XueLi | 2021 | Science China(Technological Sciences)2021，64，7： | 1 |
| 6 | Understanding of physiological neural firing through dy- namical bifurcation machineries显示文摘 | Yang Minghao An Shucheng Gu Huaguang | 2006 | Neuroreport2006，17，10： | 1 |
| 7 | A series of bifurcation scenarios in the firing transitions in an exper- imental neural pacemaker 显示文摘 | Li Li Gu Huaguang Yang Minghao | 2004 | International Journal of Bifurcation and Chaos2004，14，5： | 1 |
| 8 | Dynamics of period-doubling bifurcation to chaos in the spontaneous neural firing patterns显示文摘 | Bing Jia Huaguang Gu Li Li Xiaoyan Zhao | 2012 | Cognitive Neurodynamics2012，，1： | 1 |
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