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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | Recrudescent Plasmodium falciparum infections in children in an endemic area following artemisinin–based combination treatments: Implications for disease control显示文摘 | Grace O Gbotosho Titilope M Okuboyejo Christian T Happi Akintunde Sowunmi | 2011 | Asian Pacific Journal of Tropical Disease2011，，3： | 2 |
| 3 | Intensity-modulated arc therapy: principles tec- hnologies anti clinical implementation显示文摘 | Cedric XY Grace T | 2011 | Phys Med Biol2011，56，5： | 1 |
| 4 | Biomass gasification in a circulating fluidized bed显示文摘 | Li X T Grace J R Lim C J | | 0，，02： | 1 |
| 5 | Sequence and spacing of TATA box elements are critical for accurate initiation from the β-phaseolin promoter显示文摘 | GRACE M L CHANDRASEKHARAN M B HALL T C CROWE A J | 2004 | Biological Chemistry2004，279，： | 1 |
| 6 | High Altitude Platforms for Wireless Communications显示文摘 | TOZER T C GRACE D | 2001 | Electronics & Communication Engineering Journal2001，13，3： | 1 |
| 7 | Effects of hydrogel/ silver coatings on in vitro adhesion to catheters of bacteria associated with urinary tract infection显示文摘 | AHEAM D G GRACE D T JENNINGS M J | 2000 | Curr Microbiol2000，41，2： | 1 |
| 8 | High-altitude platforms for wireless commu- nications显示文摘 | TOZER T C GRACE D | 2001 | Electronic & Communications Engineering Journal2001，13，3： | 1 |
| 9 | Chaotic behavior of fluidized beds based on pressureand voidage fluctuations 显示文摘 | Bi H T Grace J R | 1997 | AIChE J1997，43，5： | 1 |
| 10 | Biomass gasification in a circulating fluidized bed显示文摘 | Li X T Grace J R Lim C J | 2004 | Biomass Bioenergy2004，26，： | 1 |
| 11 | 一期与分期双侧全膝置换术的围手术期风险比较显示文摘一期双侧全膝置换术有逐渐增多的趋势,作者比较了27301例一期与45419例分期双侧全膝置换术的病死率、内科并发症、感染率和机械并发症。一期双侧全膝置换术病死率、心脏事件、血栓栓塞事件、泌尿消化道并发症发生率都高于分期手术。因此作者认为,一期双侧全膝置换术增加一定的围手术期风险。 | Tsay E L Grace T R Vail T 胡孔足 | 2019 | 临床骨科杂志2019，22，4： | 1 |
| 12 | Biomass gasification in a circulating fluidized bed 显示文摘 | X T LI J R GRACE C J LIM et d | 2004 | Biomass and Bioenergy2004，28，3： | 1 |
| 13 | Migration of polybrominated diphenyl ethers in biosolids-amended soil 显示文摘 | Gorgy T Li L Y Grace J R | 2013 | Environmental Pollution2013，172，： | 1 |
| 14 | Biology of invasive termites : a worldwide review显示文摘 | Evans T A Forschler B T Grace J K | 2013 | Ann Rev Entomol2013，58，： | 1 |
| 15 | Hydrodynam ics of the stripper section of fluid cokers显示文摘 | BI H T GRACE J R LIM C J | 2005 | The Ca nadian Journal of Chemical Engineering2005，83，： | 1 |
| 16 | Reduction of Electrostatic Charges in Gas-solid Fluidized Beds 显示文摘 | PARK A BI H T GRACE J R | 2002 | Chem Eng Sci2002，57，： | 1 |
| 17 | An investigation of thelimits of phosphorus removal in wetlands:A mesocosm study of a shal-low periphyton-dominated treatment system显示文摘 | DeBusk T A Grace K A Dierberg F E | 2004 | Ecological Engineering2004，23，1： | 1 |
| 18 | Does species diversity limit productivity in natural grassland communities显示文摘 | GRACE J B MICHAEL A T SMITH M D | 2007 | Ecology Letters2007，10，8： | 1 |
| 19 | On sequential labelings of graphs显示文摘 | T Grace | 1983 | Graph Theory1983，，7： | 1 |
| 20 | Photodynamic ther- apy: an innovative approach to the treatment of keloid dis- ease evaluated using subjective and objective non-invasive tools显示文摘 | SARA UD GRACE T JULIE M | 2013 | Arch Dermatol Res April2013，305，3： | 1 |
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