|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Vascular endothelial growth factor receptor 2(VEGFR-2) plays a key role in vasculogenic mimicry formation,neovascularization and tumor initiation by Glioma stem-like cells显示文摘Human glioblastomas(GBM)are thought to be initiated by glioma stem-like cells(GSLCs).GSLCs also participate in tumor neovascularization by transdifferentiating into vascular endothelial cells.Here,we report a critical role of GSLCs in the formation of vasculogenic mimicry(VM),which defines channels lined by tumor cells to supply nutrients to early growing tumors and | Yao X Ping Y Liu Y Chen K Yoshimura T Liu M Gong W Chen C Niu Q Guo D Zhang X Wang JM Bian X | 2013 | 中国神经肿瘤杂志2013，11，3： | 23 |
| 2 | Advances in immuno-oncology biomarkers for gastroesophageal cancer:programmed death ligand 1,microsatellite instability,and beyond显示文摘Blockade of the programmed death ligand 1(PD-L1) and programmed cell death 1(PD-1) receptor axis represents an effective form of cancer immunotherapy. Preclinical evidence initially suggested that gastric and gastroesophageal junction(GEJ) cancers are potentially immunotherapy-sensitive tumors. Early phase clinical trials have demonstrated promising antitumor activity with PD-1/PD-L1 blockade in advanced or metastatic gastric/GEJ cancer. Microsatellite instability(MSI) and PD-L1 expression have been shown to predict higher response to PD-1 inhibitors as highlighted by the recent approvals of pembrolizumab in treatmentrefractory solid tumors with MSI status and the thirdline or greater treatment of PD-L1 positive advanced gastric/GEJ cancers. However, predictive and prognostic biomarkers remain an ongoing need. In this review, we detail the preclinical evidence and early tissue biomarker analyses illustrating potential predictive biomarkers to PD-1/PD-L1 blockade in gastric/GEJ cancer. We also review the clinical development of PD-1/PD-L1 inhibitors in gastric/GEJ cancer and highlight several areas in need of future investigation in order to optimize the efficacy of PD-1/PD-L1 blockade in gastric/GEJ cancer. | Emily M Lin Jun Gong Samuel J Klempner Joseph Chao | 2018 | World Journal of Gastroenterology2018，24，25： | 10 |
| 3 | Clinical development of reovirus for cancer therapy:An oncolytic virus with immune-mediated antitumor activity显示文摘 | Jun Gong Esha Sachdev Alain C Mita Monica M Mita | 2016 | World Journal of Methodology2016，6，1： | 8 |
| 4 | 超导量子比特应用到量子随机行走显示文摘将对多体物理现象模拟和通用量子计算产生影响创新点量子随机行走利用量子叠加态的特性,粒子在格点中的行走特性需要用量子力学来诠释,是经典随机行走在量子力学中的拓展。中国科学技术大学潘建伟、朱晓波、彭承志等实验团队,联合中国科学院物理研究所范桁等理论团队,开创性地将超导量子比特应用到量子随机行走的研究中,实验上首次在固态量子计算系统中演示了强关联纠缠体系的量子随机行走,将对未来多体物理现象的模拟以及利用量子随机行走进行通用量子计算研究产生重要影响。 | YAN Z ZHANG Y R GONG M | 2019 | 张江科技评论2019，0，3： | 7 |
| 5 | Appearance of an inhibitory cell nuclear antigen in rat and human serum during variable degrees of hepatic regenerative activity显示文摘METHODSInanimalstudies,adultmaleSpragueDawleyrats(n=3-4/group)weresacrificedat0,12,24,36,48,72and96hoursfollowing70%partia... | N Assy 1,2 ,YW Gong 3,M Zhang 3 and GY Minuk 3,4 | 1999 | World Journal of Gastroenterology1999，5，2： | 6 |
| 6 | Numerical and safety considerations about the Daguangbao landslide induced by the 2008 Wenchuan earthquake显示文摘The 2008 Wenchuan earthquake resulted in a large number of fatalities and caused significant economic losses.Thousands of landslides,many of which are very large,were triggered by the earthquake.A majority of catastrophic landslides were distributed along the central Longmenshan fault system,at the eastern margin of the Tibetan Plateau.Some of the landslides resulted in sudden damming of rivers causing flooding,which in turn induced secondary sliding disasters.Among the most significant landslides,the Daguangbao landslide was the largest in volume with the maximum thickness.For this,a numerical model of the Daguangbao landslide,using the material point method(MPM),was developed to simulate the interaction of the seismic loads imposed on the slope.The numerical results then are compared with the post-earthquake profile.As a consequence of the landslide,a nearly vertical head scarp with a maximum height of about 700 m was generated.This is considered as a high risk situation that requires constant monitoring and evaluation.Finally,we propose a methodology based on Bayesian networks(BNs)to manage the risk associated with the stability of the rockwall at the Daguangbao landslide site. | Manchao He L.Ribeiro e Sousa AndréMüller Eurípedes Vargas Jr. R.L.Sousa C.Sousa Oliveira Weili Gong | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，5： | 4 |
| 7 | 肠道微生态失调与高血压的关系显示文摘新出现的证据表明,肠道菌群是维持生理动态平衡的关键,该研究旨在验证微生态失衡的肠道菌群与高血压相关这一假设,因为遗传、环境和膳食因素对肠道菌群和血压有很大影响。方法:从2种高血压模型大鼠和一个小队列患者人群的粪便样本中提取细菌DNA,用于细菌基因组的分析. | 刘莉 叶鹏 Yang T Santisteban MM Rodriguez V Li E Ahmari N Carvajal JM Zadeh M Gong M Qi Y Zubcevic J Sahay B Pepine CJ Raizada MK Mohamadzadeh M | 2015 | 中华高血压杂志2015，23，5： | 4 |
| 8 | Plasmonic-enhanced two-photon fluorescence with single gold nanoshell显示文摘Single gold nanoshell with mutilpolar plasmon resonances is proposed to enhance two-photon fluorescence efficiently.The single emitter single nanoshell configuration is studied systematically by employing the finite-difference time-domain method.The emitter located inside or outside the nanoshell at various positions leads to a significantly different enhancement effect.The fluorescent emitter placed outside the nanoshell can achieve large fluorescence intensity given that both the position and orientation of the emission dipole are optimally controlled.In contrast,for the case of the emitter placed inside the nanoshell,it can experience substantial two-photon fluorescence enhancement without strict requirements upon the position and dipole orientations.Metallic nanoshell encapsulating many fluorescent emitters should be a promising nanocomposite configuration for bright two-photon fluorescence label.The results provide a comprehensive understanding about the plasmonic-enhanced two-photon fluorescence behaviors,and the nanocomposite configuration has great potential for optical detecting,imaging and sensing in biological applications. | ZHANG TianYue LU GuoWei SHEN HongMing Perriat P Martini M Tillement O GONG QiHuang | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，6： | 2 |
| 9 | Inhibition Behavior of Imidazoline Phosphate Compound Inhibitor on Q235 Steel in Hydrochloric Acid Medium显示文摘 | Zhang J Gong X-L Yu H-H Du M | 2011 | Corrosion2011，，4： | 2 |
| 10 | Calmodulin-binding proteins from zea mays germs 显示文摘 | Gong M Li Z G | 1995 | Phytochemistry1995，40，5： | 1 |
| 11 | Structural evolution of mechanically alloyed nanocrystalline Fe-28Al powders显示文摘 | FAN R H SUN J T GONG H Y SUN K N WANG W M | 2005 | Powder Technol2005，149，： | 1 |
| 12 | Immobilization of DNAzyme catalytic beacons on PMMA for Pb^2+ detection显示文摘 | Dalavoy T S Wernette D P Gong M | 2008 | Lab on a Chip-Miniaturisation for Chemistry and Biology2008，8，5： | 1 |
| 13 | 显示文摘 | Gong H Wilk G D | 2002 | Appl Phys Lett2002，81，： | 1 |
| 14 | Generation of dual wavelength ultrashort pulse outputs from a passive mode locked fiber ring laser显示文摘 | Gong Y D Tian X L Tang M | 2006 | Optics Communications2006，265，： | 1 |
| 15 | Preparation of po显示文摘 | XU J W SHI W F GONG M | 2005 | J Appl Polym Sci2005，97，4： | 1 |
| 16 | Effects of preoperative interventions on outcome following liver resection in a rat model of cirrhosis 显示文摘 | Moser M Zhang M Gong Y | 2000 | J Hepatol2000，32，： | 1 |
| 17 | Effects of PPAR gagonist pioglitazone on rat hepatic fibrosis显示文摘 | YUAN G J ZHANG M L GONG Z J | 2004 | World J Gastroenterol2004，10，： | 1 |
| 18 | Involvement of calcium and calmodulin in the acquired of heat-shock induced thermotolerance in maize seedlings显示文摘 | Gong M Li Y J | 1997 | Plant Physiol1997，150，： | 1 |
| 19 | Comparison between methods for glutathione reductase activity assays in maize seedlings显示文摘 | GUO L H CHEN S N GONG M | 1999 | Journal of Yunnan University1999，21，5： | 1 |
| 20 | Behavior and design of reinforced concrete, steel, and steel-concrete coupling beams显示文摘 | KENT A HARRIES M EERI BINGNIAN GONG BAHRAM M SHAHROOZ | 2000 | Earthquake Spectra2000，16，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员