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| 1 | Aging:A mitochondrial DNA perspective,critical analysis and an update显示文摘The mitochondrial theory of aging, a mainstream theory of aging which once included accumulation of mitochondrial DNA(mt DNA) damage by reactive oxygen species(ROS) as its cornerstone, has been increasingly losing ground and is undergoing extensive revision due to its inability to explain a growing body of emerging data. Concurrently, the notion of the central role for mtDNA in the aging process is being met with increased skepticism. Our progress in understanding the processes of mtDNA maintenance, repair, damage, and degradation in response to damage has largely refuted the view of mt DNA as being particularly susceptible to ROS-mediated mutagenesis due to its lack of 'protective' histones and reduced complement of available DNA repair pathways. Recent research on mitochondrial ROS production has led to the appreciation that mitochondria, even in vitro, produce much less ROS than previously thought, automatically leading to a decreased expectation of physiologically achievable levels of mtDNA damage. New evidence suggests that both experimentally induced oxidative stress and radiation therapy result in very low levels of mtDNA mutagenesis. Recent advances provide evidence against the existence of the 'vicious' cycle of mtDNA damage and ROS production. Meta-studies reveal no longevity benefit of increased antioxidant defenses. Simultaneously, exciting new observations from both comparative biology and experimental systems indicate that increased ROS production and oxidative damage to cellular macromolecules, including mtDNA, can be associated with extended longevity. A novel paradigm suggests that increased ROS production in aging may be the result of adaptive signaling rather than a detrimental byproduct of normal respiration that drives aging. Here, we review issues pertaining to the role of mtDNA in aging. | Inna N Shokolenko Glenn L Wilson Mikhail F Alexeyev | 2014 | World Journal of Experimental Medicine2014，4，4： | 6 |
| 2 | Analysis of LiDAR-derived Topographic Information for Characterizing and Differentiating Landslide Morphology and Activity显示文摘 | Glenn N F Streutker D R Chadwick D J | 2006 | Geonmrphology2006，73，12： | 1 |
| 3 | Analysis of LiDAR-derived topographic information for characterizing and differentiating landslide morphology and activity显示文摘 | Glenn N F Streutker D R Chadwick D J | | 0，，01： | 1 |
| 4 | The use of geostatistics in relating soil moisture to RADARSAT-1 SAR data obtained over the Great Basin,Nevada,USA显示文摘 | Glenn N F Carr G R | 2003 | Computers & Geosciences2003，29，： | 1 |
| 5 | Multi-modal change detection, application to the detection of flooded areas:outcome of the 2009-2010 data fusion contest显示文摘 | Longbotham N Pacifici F Glenn T | 2012 | IEEE Journal of Selected Topics in Applied Earth Obser- vations and Remote Sensing2012，5，1： | 1 |
| 6 | LiDAR Measurement of Sagebrush Steppe Vegetation Heights显示文摘 | Streutker D R Glenn N F | 2006 | Remote Sensing of Environment2006，102，12： | 1 |
| 7 | A nalysis of LiDAR derived topographic information for characterizing and differentiating landslide morphology and activity显示文摘 | GLENN N F STREUTKER D R CHADWICK D J | 2006 | Geomorphology2006，73，： | 1 |
| 8 | Mapping sagebrush distribution using fusion of hyperapactral and lidar classifications显示文摘 | Mundt J T Streutker D R Glenn N F | 2006 | Photogrammetric Engineering and Remote Sensing2006，72，1： | 1 |
| 9 | Subpixel abundance estimates in mixture-tuned matched filtering classifications of leafy spurge显示文摘 | MITCHELL J J GLENN N F | 2009 | International Journal of Remote Sensing2009，，30： | 1 |
| 10 | A Prospective Study of the Diagnostic Accuracy of PillCam ESO Esophageal Capsule Endoscopy Versus Conventional Upper Endoscopy in Patients With Chronic Gastroesophageal Reflux Diseases显示文摘 | Rami Eliakim Virender K Sharma Kamel Yassin Samuel N Adler Harold Jacob David R Cave Ritu Sachdev Roger D Mitty Dirk Hartmann Dieter Schilling Jurgen F Riemann Simon Bar-Meir Eytan Bardan Brian Fennerty Glenn Eisen Douglas Faigel Blair S Lewis David E Fle | 2005 | Journal of Clinical Gastroenterology2005，，7： | 1 |
| 11 | A Review of Remote Sensing of Invasive Weeds and Example of the Early Detection of Spotted Knapweed (Centaurea Maeulosa) and Babysbreath (Gypsophila Paniculata) with a Hyperspectral Sensor 显示文摘 | Lass L W Prather T S Glenn N F | 2005 | Weed Science2005，53，： | 1 |
| 12 | The use of geostatistics in relating soil moisture to RADARSAT - 1 SAR data obtained over the Great Basin, Nevada, USA 显示文摘 | Glenn N F Carr J R | 2003 | Computers and Geosciences2003，29，5： | 1 |
| 13 | Hyperspectral Data Processing for Repeat Detection of Small Infestations of Leafy Spurge显示文摘 | Glenn N F Mundt J T Weber K T | 2005 | Remote Sensing of Environment2005，95，： | 1 |
| 14 | Discrimination of Hoary Cress and determination of its detection limits via hyperspectral image processing and accuracy assessment techniques 显示文摘 | Mundt J T Glenn N F Weber K T | 2005 | Remote Sensing of Environment2005，96，1： | 1 |
| 15 | Behavioral and electrophysiological responses of aphids to host and nonhost plant volatiles显示文摘 | Stephen F N Jim Hardie Glenn W D | 1991 | Journal of Chemical Ecology1991，17，6： | 1 |
| 16 | The use of geostatistics in relating soil moisture to RADARSAT-1 SAR data obtained over the Great Basin,Nevada,USA显示文摘 | Glenn N F Carr J R | 2003 | Computers&Geosciences2003，29，5： | 1 |
| 17 | Integrating LiDAR Intensity and Elevation Data for Terrain Characterization in a Forested Area显示文摘 | Wang C Glenn N F | 2009 | IEEE Geoscience and Remote Sensing Letters2009，6，3： | 1 |
| 18 | A review of remote sensingof invasive weeds and example of the early detection of spotted knapweed(Centaurea maculosa)and babysbreath(Gypsophila paniculata)with ahyperspectral sensor显示文摘 | LASS L W PRATHER TS GLENN N F | 2005 | Weed Science2005，53，2： | 1 |
| 19 | Triblock copolymer syntheses ofmesoporous silica with periodic 50 to 300 angstrom pores 显示文摘 | Zhao D Feng J Huo Q Melosh N Fredrickson Glenn H ChmelkaBradley F Stucky Galen D | 1998 | Science1998，279，5350： | 1 |
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