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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Casein kinase 1 delta ( CK1 δ) interacts with the SNARE associated protein SNAPIN 显示文摘 | Wolff S Stoter M Giamas G | 2006 | FEBS Lett2006，580，27： | 1 |
| 4 | The estrogen receptor- alpha-induced microRNA signature regulates itself and its transcriptional response显示文摘 | Castellano L Giamas G Jacob J | 2009 | Proc Natl Acad Sci USA2009，106，15： | 1 |
| 5 | Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer显示文摘 | Giamas G Filipovic A Jacob J | 2011 | Nat Med2011，17，6： | 1 |
| 6 | CK1 delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions显示文摘 | GIAMAS G CASTELLANO L FENG Q | | 0，，09： | 1 |
| 7 | Protein kinases as targets for cancer treatment显示文摘 | Giamas G Stebbing J Vorgias CE | 2007 | Pharmacogenomics2007，8，8： | 1 |
| 8 | Kinases as targets in the treatment of solid tumors显示文摘 | Giamas G Man YL Hirner H | 2010 | Cell Signal2010，22，7： | 1 |
| 9 | Environmental performance cvalualion of thermal insulation materials and its impact on the building 显示文摘 | Papadopoulos A M Giama E | 2007 | Building and Environment2007，42，5： | 1 |
| 10 | The role of the casein kinase 1(CK1)Family in different signaling pathways linked to cancer development显示文摘 | KNIPPSCHILD U WOLFF S GIAMAS G | 2005 | Onkologie2005，28，10： | 1 |
| 11 | Kinases as targets in the treatment of solid tumors 显示文摘 | GIAMAS G MAN YL HIRNER H | 2010 | Cell Signal2010，22，7： | 1 |
| 12 | The role ofthe casein kinase 1(CK1)family in different signalingpathways linked to cancer development显示文摘 | Knippschild U Wolff S Giamas G | 2005 | Onkologie2005，28，10： | 1 |
| 13 | Kinome screening for regula- tors of the estrogen receptor identifies LMTK3 as a new therapeutic tar- get in breast cancer显示文摘 | Giamas G Filipovifi A Jacob J | 2011 | Nature Med2011，17，6： | 1 |
| 14 | The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development显示文摘 | Knippschild U Wolff S Giamas G | 2005 | Onkologie2005，28，10： | 1 |
| 15 | The role of the ca- sein kinase I(CK1) family in different signaling pathways linked to cancer development显示文摘 | Knippschild U Wolff S Giamas G et at | 2005 | Onkologie2005，28，10： | 1 |
| 16 | The role of the casein kinase 1 ( CK1 ) family in different signaling pathways linked to cancer development 显示文摘 | KNIPPSCHILD U WOLFF S GIAMAS G | 2005 | Onkologie2005，28，： | 1 |
| 17 | High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence显示文摘BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV prevalence resulting in variations in cirrhosis and HCC.We previously reported high prevalence of HBV and HCV infections in Somali immigrants seen at an academic medical center in Minnesota.AIM To determine the prevalence of chronic viral hepatitis in Somali immigrants in Minnesota through a community-based screening program.METHODS We conducted a prospective community-based participatory research study in the Somali community in Minnesota in partnership with community advisory boards,community clinics and local mosques between November 2010 and December 2015(data was analyzed in 2020).Serum was tested for hepatitis B surface antigen,hepatitis B core antibody,hepatitis B surface antibody and anti-HCV antibody.RESULTS Of 779 participants,15.4%tested positive for chronic HBV infection,50.2%for prior exposure to HBV and 7.6%for chronic HCV infection.Calculated age-adjusted frequencies in males and females for chronic HBV were 12.5%and 11.6%;for prior exposure to HBV were 44.8%and 41.3%;and for chronic HCV were 6.7%and 5.7%,respectively.Seven participants developed incident HCC during follow up.CONCLUSION Chronic HBV and HCV are major risk factors for liver disease and HCC among Somali immigrants,with prevalence of both infections substantially higher than in the general United States population.Community-based screening is essential for identifying and providing health education and linkage to care for diagnosed patients. | Essa A Mohamed Nasra H Giama Abubaker O Abdalla Hassan M Shaleh Abdul M Oseini Hamdi A Ali Fowsiyo Ahmed Wesam Taha Hager Ahmed Mohammed Jessica Cvinar Ibrahim A Waaeys Hawa Ali Loretta K Allotey Abdiwahab O Ali Safra A Mohamed William S Harmsen Eimad M Ahmmad Numra A Bajwa Mohamud D Afgarshe Abdirashid M Shire Joyce E Balls-Berry Lewis R Roberts | 2022 | World Journal of Gastroenterology2022，28，35： | 0 |
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