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| 1 | 睾丸活检:临床操作及其诠释显示文摘睾丸活检许多年来被认为是不明病因男性不育和无精症诊断的基础。近来,男性不育指南都限定诊断性睾丸活检只能用于梗阻性无精子症(睾丸体积正常,生殖激素正常)的鉴别诊断。现今,睾丸活检取精技术与胞浆内单精子显微注射(ICSI)联用于非梗阻性无精子症患者的取精过程中。此外,睾丸活检还可以应用于有睾丸恶性肿瘤风险的患者的取精治疗中。研究一些不育男性后发现,不育患者患原位睾丸癌的风险越来越高,尤其是曾有隐睾症、睾丸恶性肿瘤病史,或患睾丸萎缩的患者。睾丸超声异常,比如睾丸微石症,实质内呈弥散分布,软细胞组织不均、睾丸组织损伤等,进一步增加了这些患者原位癌的发病率。准确的组织学分类,正确的组织处理和固定,样品准备和评估是必须的。同时,推荐使用标准的睾丸活检方法。另外,通过免疫组织化学法检测睾丸组织的肿瘤恶化程度是不可缺少的技术支持。本综述主要描述了睾丸活检用于男性不育临床诊断和治疗措施的最新进展。 | Gert R Dohle Saad Elzanaty Niels J van Casteren | 2012 | Asian Journal of Andrology2012，14，1： | 13 |
| 2 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 3 | Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis显示文摘恶意的阴囊的细菌房间肿瘤(TGCT ) 与 70% 增加的发生最后是在白种人男性(20-40 年) 的最经常的癌症 20 年,可能由于联合行动(epi ) 基因并且(微) 环境因素。TGCT 作为他们的普通先锋在 situ (CIS ) 有癌,这被期望,从在它的成熟过程堵住的一个胚胎的细菌房间发源。然而, TGCT 的全面痊愈率是超过 90% 人幸存 TGCT 能介绍全身的癌症治疗的长期的副作用。相反,没有这些长期的副作用,为 CIS 诊断并且对待的人仅仅继续生活。因此, CIS 的早察觉有大健康好处,它将要求一个增进知识的屏蔽方法。这评论描述了病原学和早察觉的 TGCT 和为 TGCT 在风险屏蔽人的未来潜力的早致病。为屏蔽,明确的风险侧面基于基因、环境的风险因素被需要。自从 2009 ,宽协会学习的几个染色体( GWAS )被出版了,在有重要协会在或在基因 KITLG , SPRY4 , BAK1 , DMRT1 , TERT , ATF7IP , HPGDS , MAD1L1 , RFWD3 , TEX14 ,和 PPM1E 附近的单个核苷酸的多型性( SNP )上报导,可能与 TGCT 开发有关。出生前, perinatal,和出生后的环境因素也影响 CIS 的发作。noninvasive 为 CIS 的早察觉方法将在一个临床的背景,在精液的特定的 miRNA 察觉为似乎很有希望是高度有益的。进一步的研究被需要发展基于基因环境相互作用,明确的 TGCT 风险侧面为 CIS 与 noninvasive 察觉方法结合了。 | Jenny E Elzinga-Tinke Gert R Dohle Leendert HJ Looijenga | 2015 | Asian Journal of Andrology2015，17，3： | 4 |
| 4 | How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility显示文摘Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is debated.The aim of this study was to compare successful resection rates(RR)with upfront ALPPS vs.PVE with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ALPPS.Methods:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day mortality.Results:A total of 189 patients were included.Successful RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on demand.The sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS. | Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok Peter Nørgaard Larsen Nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 2 |
| 5 | Structure and properties of reinforcing fractal filler networks in elastomers显示文摘 | Kluppel M Schuster R H Gert H | 1997 | Rubber Chem Technol1997，70，2： | 1 |
| 6 | Domestic animals and epidemiology of visceral Leishmaniasis, Nepal 显示文摘 | Narayan RB Gert VA Suman R | 2010 | Emerg Infect Dis2010，16，2： | 1 |
| 7 | The method of public morality versus the method of principlism显示文摘 | Green R M Gert B Clouser K D | | Journal of Medicine and Phi losophy0，，18： | 1 |
| 8 | Osmotic pumping release from ethyl- hydroxypropyl -cellulose - coated pellets: A new mechanistic model 显示文摘 | Mariagrazia M Gert R Bernt N | 2010 | J Control Release2010，142，1： | 1 |
| 9 | Environmental Conflicts in Compact Cities: Complexity, Decisionmaking, and Policy Approaches 显示文摘 | Gert D R | 2000 | Environment and Planning B: Planning and Design2000，27，2： | 1 |
| 10 | Development of nitrile butadiene rubber-nanoclay composites with epoxidized natural rubber as compatibilizer显示文摘 | Rajasekar R Kaushik Pal Gert Heinrich | 2009 | Materials and Design2009，30，： | 1 |
| 11 | Autoantibodies to asialoglycoprotein receptor ( ASGPR ) measured by a novel ELISA-revival of a disease - activity marker in autoimmune hepatitis 显示文摘 | Gert H Dirk R Eugen F | 2009 | Clin Chim Acta2009，408，12： | 1 |
| 12 | Annual changes in sea-ice, chlorophyll a , and primary production in the Ross Sea, Antarctica显示文摘 | Kevin R Arrigo Gert L van Dijken | 2004 | Deep-Sea Research Part II2004，，1： | 1 |
| 13 | Liquid crystalline perylene-3, 4-dicarboximide derivatives with high thermal and photochemical stability显示文摘 | CHRISTIAN M VOLKER E | 1998 | Materials Science1998，81，1： | 1 |
| 14 | Push-off force in speed skating 显示文摘 | Koning J J de R W de Boer Gert de Groot and G J van Ingen Schenau | 1987 | Sport Biomech1987，，3： | 1 |
| 15 | Learning the kernel matrix with semidefinite programming显示文摘 | Gert R G Lanckriet NeUo Cristianini Peter Bartlett Laurent E1Ghaoui Michael I Jordan | 2004 | The Journal of Machine Learn- ing Research2004，5，1： | 1 |
| 16 | Environmental conflicts in compact cities:complexity, de- cision making, and policy approaches 显示文摘 | Gert D R | 2000 | Environment and Plan- ning B : Planning and Design2000，27，2： | 1 |
| 17 | Selecting target species to evaluate the success of wet grassland restoration显示文摘 | GERT R | 2003 | Agriculture Ecosystems and Environment2003，98，： | 1 |
| 18 | Liposomal nanomedicines as anticancer therapeutics: beyond targeting tumor cells 显示文摘 | SCHIFFELERS R M GERT S | 2008 | Int J Pharm2008，364，2： | 1 |
| 19 | Polycondensations of bisphenol-A with diphosgene or triphosgene in water-free organic solvents显示文摘 | Hans R Kricheldorf Sigrid Bohme Gert Schwarz | 2005 | Macromol Chem Phys2005，206，： | 1 |
| 20 | Performance of active PhotosystemlI centers in photoinhibited pea leaves显示文摘 | Gert S Jack J S R | 1999 | Photosynth Res1999，62，2： | 1 |
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