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| 1 | Effect of N-desulfated heparin on hepatic/renal ischemia reperfusion injury in rats显示文摘AIM: To investigate the effect of N-desulfated heparin onhepatic/renal ischemia and reperfusion injury in rats.METHODS: Using rat models of 60 minutes hepatic or renalischemia followed by 1 h,3 h,6 h and 24 h reperfusion,animalswere randomly divided into following groups,the shamoperated controls,ischemic group receiving only normalsaline,and treated group receiving N-desulfated heparin ata dose of 12 mg/kg at 5 minutes before reperfusion. P-selectin expression was detected in bepatic/renal tissueswith immunohistochemistry methodRESULTS: P-selectin expression, serum ALT, AST, BUN andCr levels were significantly increased during 60 minuteischemia and 1 h, 3 h, 6 h and 24 h reperfusion,while theincrement was significantly inhibited,and hepatic/renalpathology observed by light microscopy was remarkablyimproved by treatment with the N-desulfated heparin.Furthermore,the heparin was found no effects on PT and KPTT.CONCLUSION: P-selectin might mediate neutrophilinfiltration and contribute to hepatic/renal ischemia andreperfusion. The N-desulfated heparin might preventhepatic/renal damage induced by ischemia and reperfusioninjury without significant anticoagulant activity. | Tong Zhou Wei Song Feng Wang Department of Nephrology,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China Jin-Lian Chen Department of Gastroenterology,Shanghai Sixth People’s Hospital,Shanghai 200233,China Ming-Jun Zhang Animal Laboratory,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China Pei-Hua Ni,Department of Biochemistry,Shanghai Second Medical University,Shanghai 200025 Jian-Guo Geng Institute of Biochemistry and Cell Biology,Shanghai 200030,China | 2002 | World Journal of Gastroenterology2002，8，5： | 20 |
| 2 | Tongxinluo Improves Apolipoprotein E-Deficient Mouse Heart Function显示文摘 | Guo-Qiang Yuan Song Gao Yong-Jian Geng Yao-Ping Tang Min-Juan Zheng Harnath S Shelat Scott Collins Han-Jing Wu Yi-Ling Wu | 2018 | Chinese Medical Journal2018，，5： | 8 |
| 3 | Effects of Dan-Shao-Hua-Xian on the expression of collagen type I and III in rats with hepatic fibrosis显示文摘BACKGROUND: Hepatic fibrosis is the common patholo gical change in various chronic liver diseases,and its major cause is the imbalance between the production and degra dation of the extracellular matrix, which is mainly com posed of collagens. Dan-Shao-Hua-Xian ( DSHX) cap sule, a traditional Chinese herbal compound, has shown marked preventive effects on hepatic fibrosis in rats in our previous studies. The present study was designed to further investigate its therapeutic actions on hepatic fibrosis in rats and its possible mechanisms. METHODS: Eighty male Wistar rats were randomly divid- ed into normal control group, hepatic fibrosis group, non DSHX-treated group, low-dose-treated group, and high dose-treated group. The rat models of hepatic fibrosis were established by subcutaneous injecton of CC14 , drinking al- cohol , giving diet of hyperliprosis and hypoprotein for 8 weeks. The two DSHX-treated groups were treated respec- tively with low dose (0.5 g/kg) and high dose (1.0 g/kg) of DSHX capsule p. o. everyday for 8 weeks. At the end of the experiment, liver indexes were calculated in each group in addition to the levels of the serum hyaluronic acid and alanine aminotransferase. Their degree of hepatic fibrosis and urinary excretion of hydroxyproline and expression of collagen , were detected. RESULTS: Comparison of the indexes of the hepatic fibro- sis group and non-DSHX-treated group revealed that the liver indexes, levels of serum hyaluronic acid and alanine aminotransferase, and stage of hepatic fibrosis were all sig- nificantly reduced in the two DSHX treated groups. The urinary excretion of hydroxyproline was increased and the expression of collagen I and HI in liver tissue was lessened. These alterations were more obviously observed in the high-dose-treated group. CONCLUSION: DSHX capsule has certain therapeutic effect on hepatic fibrosis in rats. | Xiao-Xia Geng, Qin Yang, Ru-Jia Xie, Xin-Hua Luo, Cheng-Xiu Li and Ming-Liang Cheng Guizhou, China Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College Department of Pathophysiology, Guiyang Medical College Depart- ment of Infectious Diseases, People’ s Hospital of Guizhou Province and Department of Pharmacology, Guiyang Medical College | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，4： | 4 |
| 4 | Protective action of bacterial melanin against DNA damage in full UV spectrums by a sensitive plasmid-based noncellular system显示文摘 | Geng J Yu S B Wan X | 2008 | Journal of Biochemical and Biophysical Methods2008，，： | 1 |
| 5 | Cyclic deformation behavior Of in-situ aluminum matriX composites of the system Al- Al3Ti-TiB2-Al2O3 显示文摘 | Tjong S C Wang G S Geng L | 2004 | Composites Science and Technology2004，64，： | 1 |
| 6 | An improved method to knock out the asd gene of Salmonella enterica serovar Pul- lorum显示文摘 | GENG S Z JIAO X A PAN Z M | 2009 | J Biomed Biotechnol2009，2009，： | 1 |
| 7 | Good practice in health care显示文摘 | Geng V Cobussen BH Fillingham S | 2009 | Incontinent Urostomy EAUN2009，12，3： | 1 |
| 8 | 查看详情显示文摘 | Liu J Shao S Y Chen L Xie Z Y Cheng Y X Geng Y H Wang L X Jing X B Wang F S | | 0，，14： | 1 |
| 9 | Measuring China's Circular Economy显示文摘 | Geng Y Sarkis J Ulgiati S | 2013 | Science2013，339，6127： | 1 |
| 10 | Direct growth of single-crystal Pt nanowires on Sn@CNT Nanocable:3Delectrodes for highly active electrocatalysts显示文摘 | Sun S Zhang G Geng D | 2010 | Chemistry(Weinheim an der Bergstrasse Germany)2010，16，3： | 1 |
| 11 | Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging显示文摘 | Kalra S Tai P Genge A | 2006 | J Neurol2006，253，8： | 1 |
| 12 | Surface- enhanced infrared absorption (SEIRA) and its use in analysis of plasma- modified surface显示文摘 | Geng S Friedrich J Glihde J | 1999 | Journal of applied polymer science1999，71，8： | 1 |
| 13 | Combination of Kluyveromyces marxianus and sodium bicarbonate for controlling green mold of citrus fruit显示文摘 | Geng P Chen S H Hu M Y | 2011 | International Journal of Food Microbiology2011，151，： | 1 |
| 14 | Curcumin inhibits human non-small cell lung cancer A549 cell proliferation through regulation of Bcl-2/Bax and cytochrome C 显示文摘 | Li Y Zhang S Geng JX | 2013 | Asian Pacific Journal of Cancer Prevention2013，14，8： | 1 |
| 15 | Time - domain Simulation and Nonlinear Analysis on Ride Performance of Four - wheel Vehicles显示文摘 | Wang Y S He H Geng A L | 2008 | Journal of Physics:2008，96，： | 1 |
| 16 | Treatment of hepatocellular carcinoma in a mouse xenograft model with an immunotoxin which is engineered to eliminate vascular leak syndrome显示文摘 | Hao W Shuichuan S Geng K | 2007 | Cancer Immunol Immunother2007，56，： | 1 |
| 17 | Strongly polarized and efficient blue organic light-emitting diodes using monodisperse glassy nematic oligo(fluorene)s显示文摘 | Culligan S W Geng Y Chen S H | 2003 | Advanced Materials2003，15，14： | 1 |
| 18 | Contribution of the spinal cord BDNF to the development of neuropathic pain by acti- vation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation 显示文摘 | Geng S J Liao FF Dang WH | 2010 | Exp Neurol2010，222，2： | 1 |
| 19 | Epidemiological study on Clonorchis sinensis infection in Shenzhen area of Zhujiang delta in China显示文摘 | Zhang R Gao S Geng Y | 2007 | Parasitol Res2007，1，1： | 1 |
| 20 | FPAG developments for the SPARTA project: Part 2 显示文摘 | Goodsell S J Geng D Fedrigo E | 2006 | SPIE2006，6272，62： | 1 |
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