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| 1 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 2 | Age specific differences in pediatric obstructive sleep apnea显示文摘 | Don D M Geller K A Koempel J A | 2009 | Int J Pediatr Otorhinolaryn Gol2009，73，7： | 1 |
| 3 | The roles of the Hadley circulation and downward control in tropical upwelling显示文摘 | Zhou T Geller M A Hamilton K | 2006 | Journal of the Atmospheric Sciences2006，63，： | 1 |
| 4 | Phase I/II study of oncolytic herpes simplex virus NV1020 in patients with extensively pretreated refractory colorectal cancer metastatic to the liver显示文摘 | Geevarghese S K Geller D A de Haan H A | 2010 | Hum Gene Ther2010，21，9： | 1 |
| 5 | Cytokines,endotoxin and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes显示文摘 | GELLER D A NUSSLER A K SILVIO M D | 1993 | Proc Natl Acad Sci USA1993，90，2： | 1 |
| 6 | Monte carlo simulation anal- ysis of tagged fish radiotracking performance by swarming un- manned aerial vehicles in fractional order potential fields 显示文摘 | Jensen A M Geller D K ChenY Q | 2014 | J Intell Robot Syst2014，74，12： | 1 |
| 7 | Effects of environmental change on emerging parasitic diseases显示文摘 | Patz A Graczyk K Geller N | 2000 | Int J Parasitol2000，30，1213： | 1 |
| 8 | World review of la-paroscopic liver resection-2,804 patients显示文摘 | Nguyen K T Gamblin T C Geller D A | 2009 | Ann Surg2009，250，5： | 1 |
| 9 | Histologic assessment of thermal injury to tonsillectomy specimens:a comparison of electrocautery,coblation,harmonic scalpel,and tonsillotome显示文摘 | MODI V K MONFORTE H GELLER K A | 2009 | Laryngoscope2009，119，： | 1 |
| 10 | Mass profile of the infall region of the Abell 2199 supercluster 显示文摘 | Rines K Mahdavi A Geller M J | 2002 | Astronomical Journal2002，124，3： | 1 |
| 11 | World review of laparoscopic liver resection-2804 patients显示文摘 | NGUYEN K T GAMBLIN T C GELLER D A | 2009 | Ann Surg2009，250，5： | 1 |
| 12 | Laparoseopic major hepatectomy: an evolution in standard of care 显示文摘 | Dagher I O'Rourke N Geller DA Cherqui D Belli G Gamblin TC Lainas P Laurent A Nguyen KT Marvin MR Thomas M Ravindra K Fielding G Franco D Buell JF | 2009 | Ann Surg2009，250，5： | 1 |
| 13 | Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma,and metastatic adenocarcinoma显示文摘 | Lau S K Prakash S Geller S A | 2002 | Hum Pathol2002，33，12： | 1 |
| 14 | PaaSi- Cats: novel polyamino acid catalysts 显示文摘 | DHANDA A DRAUZ K H GELLER T | 2000 | Chirality2000，12，56： | 1 |
| 15 | Rate and predictors of prepubertal bipolarity during follow-up of 6 to 12-year-old depressed children 显示文摘 | Geller B Fox L W Clark K A | 1994 | J Am Aead Child Adolesc Psychiatry1994，33，： | 1 |
| 16 | Mutation analysis of the MCHR1 gene in human obesity 显示文摘 | Wermter A K Reichwald K Buch T Geller F Platzer C Huse K | 2005 | Eur J Endocrinol2005，152，： | 1 |
| 17 | World review of laparoscopic liver resection-2,804 patients 显示文摘 | Nguyen K T Gamblin T C Geller D A | 2009 | Ann Surg2009，250，： | 1 |
| 18 | Apartment residents’ and day care workers’exposures to tetrachloroethylene and deficits in visualcontrast sensitivity 显示文摘 | Schreiber J S Hudnell H K Geller A M | 2002 | Environmental HealthPerspectives2002，110，7： | 1 |
| 19 | Melanocortin-4 receptor gene variant I103 is negatively associated with obesity显示文摘 | GELLER F REICHWALD K DEMPFLE A | 2004 | American Journal of Human Genetics2004，74，3： | 1 |
| 20 | Histologic assessment of thermal injury to tonsillectomy specimens:acomparison of electrocautery,coblation,harmonic scalpel,and tonsillotome显示文摘 | MODI V K MONFORTE H GELLER K A | 2009 | Laryngoscope2009，119，： | 1 |
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