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| 1 | Using the polymerase chain reaction coupled with denaturing gradient gel electrophoresis to investigate the association between bacterial translocation and systemic inflammatory response syndrome in predicted acute severe pancreatitis显示文摘AIM: To investigate the use of PCR and DGGE to investigate the association between bacterial translocation and systemic inflammatory response syndrome in predicted severe AP.METHODS: Patients with biochemical and clinical evidence of acute pancreatitis and an APACHE Ⅱ score ≥8 were enrolled. PCR and DGGE were employed to detect bacterial translocation in blood samples collected on d1,3, and 8 after the admission. Standard microbial blood cultures were taken when there was clinical evidence of sepsis or when felt to be clinically indicated by the supervising team.RESULTS: Six patients were included. Of all the patients investigated, only one developed septic complications;the others had uneventful illness. Bacteria were detected using PCR in 4 of the 17 collected blood samples. The patient with sepsis was PCR-positive in two samples (taken on d 1 and 3), despite three negative blood cultures. Using DGGE and specific primers, the bacteria in all blood specimens which tested positive for the presence of bacterial DNA were identified as E coli.CONCLUSION: Our study confirmed thatunlike traditional microbiological techniques, PCR can detect the presence of bacteria in the blood of patients with severe AP. Therefore, this latter method in conjunction with DGGE is potentially an extremely useful tool in predicting septic morbidity and evaluating patients with the disease. Further research using increased numbers of patients, in particular those patients with necrosis and sepsis, is required to assess the reliability of PCR and DGGE in the rapid diagnosis of infection in AP. | Callum B Pearce Vitaly Zinkevich Iwona Beech Viera Funjika Ana Garcia Ruiz Afraa Aladawi Hamish D Duncan | 2005 | World Journal of Gastroenterology2005，11，45： | 11 |
| 2 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 3 | Takotsubo cardiomyopathy:A comprehensive review显示文摘Takotsubo cardiomyopathy(TCM),also known as stress cardiomyopathy,occurs in the setting of catecholamine surge from an acute stressor.This cardiomyopathy mimics acute myocardial infarction in the absence of coronary disease.The classic feature of TCM is regional wall motion abnormalities with characteristic ballooning of the left ventricle.The etiology of the stressor is often physical or emotional stress,however iatrogenic causes of TCM have been reported in the literature.In our review,we discuss medications,primarily the exogenous administration of catecholamines,and a wide array of procedures with subsequent development of iatrogenic cardiomyopathy.TCM is unique in that it is transient and has favorable outcomes in most individuals.Classically,beta-blockers and ACE-inhibitors have been prescribed in individuals with cardiomyopathy;however,unique to TCM,no specific treatment is required other than temporary supportive measures as this process is transient.Additionally,no improvement in mortality or recurrence have been reported in patients on these drugs.The aim of this review is to elucidate on the iatrogenic causes of TCM,allowing for prompt recognition and management by clinicians. | Walker Barmore Himax Patel Sean Harrell Daniel Garcia Joe B Calkins Jr | 2022 | World Journal of Cardiology2022，14，6： | 2 |
| 4 | Racial differences in effectiveness of α-fetoprotein for diagnosis of hepatocellular carcinoma in hepatitis C virus cirrhosis显示文摘 | Mindie H Nguyen Ruel T Garcia Peter W Simpson Teresa L Wright Emmet B Keeffe | 2002 | Hepatology2002，，2： | 2 |
| 5 | Role of proton pump inhibitors in the occurrence and the prognosis of spontaneous bacterial peritonitis in cirrhotic patients with ascites显示文摘 | Marie Vos Bénédicte Vroey Béatrice Garcia Garcia Clothilde Roy Fran?ois Kidd Jean Henrion Pierre Deltenre | 2013 | Liver Int2013，，9： | 2 |
| 6 | 尿酸是正常高值血压发展为高血压的一个重要危险标志物显示文摘正常高值血压常发展为高血压,是一个与心血管病和脑卒中高死亡率和高发病率相关的事件。然而,正常高值血压发展成高血压的危险因素仍不清楚。研究者采用年龄(52.1±11.0)岁日本成年高血压患者3584例(2081例为男性)的资料进行前瞻性群体研究,研究对象在2004年被发现处于正常高值血压阶段,并在2009年重新进行检查。 | 黄洁 叶鹏 Kuwabara M Hisatome I Niwa K Hara S Roncal-Jimenez CA Bjornstad P Nakagawa T Andres-Hernando A Sato Y Jensen T Garcia G Rodriguez-Iturbe B Ohno M Lanaspa MA Johnson RJ | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 7 | Chlorophyll meter estimates leaf area based nitrogen concentration of rice 显示文摘 | Peng S B Laza R C Garcia F V | 1995 | Communication of Soil Science and Plant Analysis1995，26，： | 1 |
| 8 | Postprocessing the Galerkin method : a novel approach, to approximate inertial manifolds 显示文摘 | Garcia - Archilla B Novo J Titi E S | 1998 | SIAM Journal on Numerical Analysis1998，35，： | 1 |
| 9 | Treatment with a short course of LF 15-0195 and continuous cyclosporin A attenuates acute xenograft rejection in a rat-to-mouse cardiac transplantation model 显示文摘 | Wang H Hosiawa KA Garcia B | 2003 | Xenotransplantation2003，10，4： | 1 |
| 10 | Electrochemical behaviour of chemically lithiated LixV2O5 phases显示文摘 | MILLET M PEREIRA-RAMOS T P | 1999 | Power Sources1999，8182，： | 1 |
| 11 | Glomeruli and Blood Pressure:Less of One,More of the Other显示文摘 | Brenner B M Garcia D L Anderson S | 1988 | Hypertens1988，1，： | 1 |
| 12 | Following the development of a CD4^+ T cell response in vivo: From activation to memory formation显示文摘 | Garcia S DiSanto J Stockinger B | 1999 | Immunity1999，11，2： | 1 |
| 13 | High yield production of a human therapeutic protein in tobacco chloroplasts 显示文摘 | Staub J M Garcia B Graves J | 2000 | Nat Biotechnol2000，18，： | 1 |
| 14 | Soil CO2 fluxes and the carbon budget of a grassland显示文摘 | Norman J N R Garcia & S B Verma | 1992 | Journal Geophysical research1992，97，18： | 1 |
| 15 | Concentration of orange juice by reverse osmosis显示文摘 | Medina B G Garcia A | 1988 | Food Process Engineering1988，10，3： | 1 |
| 16 | Cellular and molecular mechanisms of metformin:an overview显示文摘 | Viollet B Guigas B Sanz Garcia N | 2012 | Clin Sci(Lond)2012，122，6： | 1 |
| 17 | A moisture -in -oil model tor power transformer monitoring - part II: experimental verification 显示文摘 | GARCIA B BURGOS J C ALONSO A | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 18 | Cloning, sequencing, and expression of a cDNA encoding rat LIMP II, a novel 74-kDa lysosomal membrane protein related to the surface adhesion protein CD36显示文摘 | Vega MA Segui-Real B Garcia JA | 1991 | J Biol Chem1991，266，16： | 1 |
| 19 | An approximate inertial manifolds approach to postprocessing the Galerkin method for the navier - stokes equations显示文摘 | Garcia - Archilla B Novo J Titi E S | 1999 | Mathematics of Computation1999，68，： | 1 |
| 20 | Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine 显示文摘 | Garcia B Neninger E Torre A | 2008 | Clin Cancer Res2008，14，3： | 1 |
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