6篇
您的检索式：作者名="GAO Mingwang"
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| 1 | Effect of amino acid mutation at position 127 in 3A of a rabbitattenuated foot-and-mouth disease virus serotype Asia1 on viral replication and infection显示文摘An amino acid mutation(R127→I) in the 3A non-structural protein of an FMDV serotype Asia1 rabbit-attenuated ZB strain was previously found after attenuation of the virus. To explore the effects of this mutation on viral replication and infection, the amino acid residue isoleucine(I) was changed to arginine(R) in the infectious cDNA clone of the rabbit-attenuated ZB strain by sitedirected mutagenesis, and the R127-mutated virus was rescued. BHK monolayer cells and suckling mice were inoculated with the R127-mutated virus to test its growth property and pathogenicity, respectively. The effects of the R127 mutation on viral replication and virulence were analyzed. The data showed that there was a slight difference in plaque morphology between the R127-mutated and wild-type viruses. The growth rate of the mutated virus was lower in BHK-21 cells and its virulence in suckling mice was also attenuated. This study indicates that the R127 mutation in 3A may play an important role in FMDV replication in vitro and in pathogenicity in suckling mice. | Aiguo Xin Mingwang Zhu Qi Hu Haisheng Miao Zhenqi Peng Yuwen He Lin Gao Huachun Li | 2014 | Virologica Sinica2014，29，5： | 2 |
| 2 | Optimum designof a 3-RRR planar parallel manipulator with a singularity-freeworkspace显示文摘 | GAO Mingwang ZHANG Xianmin WU Zhi-wei | 2011 | Applied Mechanics and Materials2011，，86： | 1 |
| 3 | Optimum design of a 3 - RRR planar parallel manipulator with a singularity-free workspace显示文摘 | Gao Mingwang Zhang Xianmin Wu Zhiwei | 2011 | Applied Mechanics and Materials2011，86，： | 1 |
| 4 | Titanate nanotubes: preparation, characterization, and application in the detection of dopamine显示文摘 | Liling Niu Mingwang Shao Sheng Wang Lei Lu Huazhong Gao Jun Wang | 2008 | Journal of Materials Science2008，，5： | 1 |
| 5 | Formability enhancement in hot spinning of titanium alloy thin-walled tube via prediction and control of ductile fracture显示文摘The damage and fracture in hot spinning of titanium alloy is a very complex process under the combined effects of microstructure evolution and stress state.In this study,their dependences on processing parameters were investigated by an integrated FE model considering microstructure and damage evolution,and revealing the effects of microstructure and stress states on damage evolution.The results show that the inner surface of workpiece with the largest voids volume fraction is the place with the greatest potential of fracture.This is mainly attributed to the superposition effects of positive stress triaxiality and the smallest dynamic recrystallization(DRX)fraction andβphase fraction at the inner surface.The damage degree is decreased gradually with the increase of initial spinning temperature and roller fillet radius.Meanwhile,it is first decreased and then increased with the increases of spinning pass and roller feed rate,which can be explained based on the variations ofβphase fraction,DRX fraction,stress state and tensile plastic strain with processing parameters.In addition,the dominant influencing mechanisms were identified and discussed.Finally,the thickness reduction without defect in the hot spinning of TA15 alloy tube is greatly increased by proposing an optimal processing scheme. | Pengfei GAO Chao YU Mingwang FU Lu XING Mei ZHAN Jing GUO | 2022 | Chinese Journal of Aeronautics2022，35，2： | 1 |
| 6 | Optimum design of a 3-RRR planar parallel manipulator with a singularity-free work space显示文摘 | GAO Mingwang ZHANG Xianmin WU Zhiwei | 2011 | Applied Mechanics and Materials2011，86，： | 1 |
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