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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells显示文摘 | Liu X Wu JY Zhou F Sun XL Yao HH Yang Y Ding JH Hu G | 2006 | 中国生物学文摘2006，20，10： | 11 |
| 3 | 代谢健康的肥胖和腹型肥胖与高血压风险增加相关显示文摘代谢健康型肥胖是指具有正常代谢特征的肥胖人群。研究者在中国农村地区队列研究(the rural Chinese cohort study)的成年人中,探究了代谢健康型肥胖与高血压风险的关系。这项前瞻性队列研究纳入中国成人9137名,在基线时(2007-2008年)无高血压、2型糖尿病或血脂异常,在2013-2014年进行随访。 | 周卫(译) 袁源(审校) Zhao Y Qin P Sun HH Liu Y Liu D Zhou Q Guo C Li Q Tian G Wu X Hu D Sun X Zhang M | 2020 | 中华高血压杂志2020，28，9： | 7 |
| 4 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 5 | Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats显示文摘 | Yang Y Liu X Long Y Wang F Ding JH Liu SY Sun YH Yao HH Wang H Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 4 |
| 6 | Lasers and radiofreguency electromagnetic surgical devices in orthopaedics显示文摘 | Sherk HH Vangsness CT Thabit G | 2002 | J Bone Joint Surg2002，84，： | 1 |
| 7 | Efficient stereospecific synthesis of no-carrier-added 2- -fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution 显示文摘 | Hamacher K Coenen HH Stocklin G | 1986 | J Nucl Med1986，27，： | 1 |
| 8 | Transcatheter closure of secundun atrialseptal defects with new self centering Amplatzer septal occluder显示文摘 | Fischer G Kramer HH Stieh J | 1999 | Eur Heart J1999，20，： | 1 |
| 9 | Complications during the wada test显示文摘 | Loddenkemper T Morris HH M6ddel G | 2008 | Epilepsy Behav2008，13，55： | 1 |
| 10 | Management of im- ported malaria in Europe 显示文摘 | Askling HH Bruneel F Burehard G | 2012 | Malar J2012，11，： | 1 |
| 11 | Estimation of stage -specific fibrosis progression rate in chronic hepatitis C virus infection, a meta -analy- sis and meta -regression显示文摘 | THIEN HH YI Q DORE G J | 2008 | Hepatotogy2008，48，2： | 1 |
| 12 | Hcart-rate variability for discrimination of different types of neuropathy in patients with insulin-dependet diabetes mellitus显示文摘 | Osterhues HH Grossmann G Hochs M | 1998 | J Endocrinol Invest1998，21，1： | 1 |
| 13 | Albuminuria atherapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy 显示文摘 | De Zeeuw D Remuzzi G Parving HH | 2004 | Circulation2004，110，8： | 1 |
| 14 | Production of secretory and extracellular N-linked glycoproteins in Escherichia coli显示文摘 | Adam CF Charles HH Cassandra G | | 0，，03： | 1 |
| 15 | MDM2-master regulator of the p53 tumor suppressor protein显示文摘 | Momand J Wu HH Dasgupta G | 2000 | Gene2000，242，12： | 1 |
| 16 | Albuminuria,a thera-peutic target for cardiovascular protection in type 2 diabeticpatients with nephropathy 显示文摘 | de Zeeuw D Remuzzi G Parving HH | 2004 | Circulation2004，110，8： | 1 |
| 17 | Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism显示文摘 | Deretic V Singh S Master S Harris J Roberts E Kyei G Davis A Haro S Naylor J Lee HH Vergne I | | Cell Microbiol0，8，5： | 1 |
| 18 | FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4 + CD25 + regulatory T cell显示文摘 | Daniel C Sartory N Zahn N Geisslinger G Radeke HH Stein JM | 2007 | J Immunol2007，178，4： | 1 |
| 19 | Prevalence of Helicobacter pylori antibodies in student in Bloemfontein South Africa 显示文摘 | Pelser HH Househam KC Joubert G | 1997 | J Pediatr Gastroenterol Nuts1997，24，： | 1 |
| 20 | Albuminuria response to very high-dose valsartan in type 2 diabetes mellitus显示文摘 | Hollenberg NK Parving HH Viberti G | 2007 | J Hypertens2007，25，9： | 1 |
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