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| 1 | Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss显示文摘Hypoxia(low oxygen level) is an important feature during infections and affects the host defence mechanisms. The host has evolved specific responses to address hypoxia, which are strongly dependent on the activation of hypoxia-inducible factor 1(HIF-1).Hypoxia interferes degradation of HIF-1 alpha subunit(HIF-1α), leading to stabilisation of HIF-1α, heterodimerization with HIF-1 beta subunit(HIF-1β) and subsequent activation of HIF-1 pathway. Apical periodontitis(periapical lesion) is a consequence of endodontic infection and ultimately results in destruction of tooth-supporting tissue, including alveolar bone. Thus far, the role of HIF-1 in periapical lesions has not been systematically examined. In the present study, we determined the role of HIF-1 in a wellcharacterised mouse periapical lesion model using two HIF-1α-activating strategies, dimethyloxalylglycine(DMOG) and adenovirusinduced constitutively active HIF-1α(CA-HIF1 A). Both DMOG and CA-HIF1 A attenuated periapical inflammation and tissue destruction. The attenuation in vivo was associated with downregulation of nuclear factor-κappa B(NF-κB) and osteoclastic gene expressions. These two agents also suppressed NF-κB activation and subsequent production of proinflammatory cytokines by macrophages. Furthermore, activation of HIF-1α by DMOG specifically suppressed lipopolysaccharide-stimulated macrophage differentiation into M1 cells, increasing the ratio of M2 macrophages against M1 cells. Taken together, our data indicated that activation of HIF-1 plays a protective role in the development of apical periodontitis via downregulation of NF-κB, proinflammatory cytokines, M1 macrophages and osteoclastogenesis. | Kimito Hirai Hisako Furusho Kiichi Hirota Hajime Sasaki | 2018 | International Journal of Oral Science2018，10，2： | 16 |
| 2 | Analysis of Ship Evacuation during Tsunami Using AIS (Automatic Identification System) Data显示文摘 | Masao Furusho Yoshiji Yano | 2012 | Journal of Earth Science and Engineering2012，2，7： | 2 |
| 3 | Involvement of interleukin(IL)-13,but not IL-4,in spontaneous IgE and IgG4 production in nephrotic syndrome显示文摘 | Kimata H Fujimoto M Furusho K | 1995 | Eur J Immunol1995，25，6： | 1 |
| 4 | Fast response MR-fluid actua-tor显示文摘 | Takesue N Furusho J | 2004 | JSME International Journal2004，47，3： | 1 |
| 5 | Effective Photocatalytic Reduction of Nitrate to Ammonia in an Aqueous Suspension of Metal-Loaded Titanium(IV) Oxide Particles in the Presence of Oxalic Acid显示文摘 | Hiroshi Kominami Akitoshi Furusho Shin-ya Murakami Hiroyuki Inoue Yoshiya Kera Bunsho Ohtani | 2001 | Catalysis Letters (-)2001，，1： | 1 |
| 6 | Control of a dynamical biped locomotion system for steady walking显示文摘 | Furusho J Masubuchi M | 1986 | Journal of Dynamic Systems Measurement and Control1986，108，2： | 1 |
| 7 | Characterization of factors involved in the production of 2 ( E ) - nonenal during mashing显示文摘 | Kuroda H Furusho S Maeba H Takashio M | 2003 | Biosci Biotechnol Biochem2003，67，： | 1 |
| 8 | High-dose intravenous gammaglobulin for Kawasaki disease显示文摘 | Furusho K Kamiya T NakanoH | 1984 | Lancet1984，2，： | 1 |
| 9 | In vitro evaluation of the efficacy of commercial green tea extracts in UV protection 显示文摘 | Silva AR Seidl C Furusho AS | 2013 | Int J Cosmet Sci2013，35，1： | 1 |
| 10 | Symmetric positive entire solutions of second-order quasilinear degenerate elliptic equations显示文摘 | Yasuhiro Furusho Kusano Taka?i Akio Ogata | 1994 | Archive for Rational Mechanics and Analysis1994，，3： | 1 |
| 11 | Pharmacologically active compounds in the A noectochilus and Goodyera species 显示文摘 | DU XIAO MING NOBUTO IRINO NORIHtRO FURUSHO | 2008 | Journal of Natural Medicines2008，62，2： | 1 |
| 12 | Occerrence of pharmaceuticals used in human and veterinary medicine in aquatic environments inJapan显示文摘 | Seino A Furusho S Masunaga S | 2004 | Journal ofJapan Society on Water Environment2004，27，11： | 1 |
| 13 | A pratieal PID controller design for speed servo system显示文摘 | Furusho J | 1998 | Tran IEEE Japan1998，118，9： | 1 |
| 14 | HLA- DRB1 * 04 is associated with the genetic susceptibility to develop vitiligo in Mexican patients with autoinanune thyroid disease显示文摘 | Orosco - Topete R Cordova - Lopez J Yamamoto - Furusho JK | 2005 | Am Acad Dermatol2005，52，1： | 1 |
| 15 | High-dose intravenous gamma-globulin for Kawasaki disease 显示文摘 | Furusho K Kamiya T Nakano H | 1984 | Lancet1984，2，8411： | 1 |
| 16 | Chirality-Memory molecule: A D2-symmetric fully substituted porphyrin as a conceptually new chirality sensor显示文摘 | Furusho Y Kjrtlur ET Mizmto Y | 1997 | J Am Chem Soc1997，119，： | 1 |
| 17 | Current status of anticoagulation therapy for elderly atrial fibrillation patients in Japan显示文摘 | Furusho H Takamura M Kaneko S | 2008 | Circ J2008，72，12： | 1 |
| 18 | Silver nanowires with a monoclinic structure fabricated by a thermal evaporation method显示文摘 | Chen C L Furusho H Mori H | 2009 | Nanotechnology2009，20，40： | 1 |
| 19 | Separation of lead from high matrix electroless nickel plating waste solution using an ion-selective immobilized macrocycle system显示文摘 | RAHMAN I M M FURUSHO Y BEGUM Z A | 2011 | Microchemical Journal2011，98，1： | 1 |
| 20 | High - dose intravenous gammaglobulin for Kawasaki disease显示文摘 | Furusho K Kamiya T Nakano H | 1984 | Lancet1984，2，8411： | 1 |
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