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| 1 | Changes in the Contents of ATP and Its Related Breakdown Compounds in Various Tissues of Oyster During Frozen Storage显示文摘The changes in the contents of adenosine 5’-triphosphate (ATP) and its related breakdown compounds were investigated in the adductor muscle, mantle, gill and body trunk of oyster (Crassostrea gigas) during frozen storage at -20℃ and -30℃ and compared with that of the fresh oyster. The investigation was performed using an HPLC system. Different extents of ATP decomposi- tion were found in various tissues frozen at the two temperatures. The K, K’ and A.E.C values were calculated as the chemical fresh- ness indices. Considering the results of sensory evaluation, the A.E.C. value in body trunk at -20℃ and -30℃ could be used as the best freshness index for frozen oyster. | WANG Qi XUE Changhu LI Zhaojie FU Xueyan XU Jie XUE Yong | 2007 | Journal of Ocean University of China2007，6，4： | 13 |
| 2 | Arsenic trioxide alleviates acute graft-versus-host disease by modulating macrophage polarization显示文摘This study aimed to explore macrophage polarization in acute graft-versus-host disease after hematopoietic stem cell transplantation, and investigated if arsenic trioxide(ATO) could correct this imbalance. In the colon of GVHD mice, we found that the number of F4/80+iNOS+ cells as well as the expression intensity of TNF-α and IL-1β was greater in the GVHD group than in the BM group, whereas the number of F4/80+CD206+ cells and the expression intensity of IL-10 and TGF-β was greater in the BM group than in the GVHD group. We investigated the effect of ATO on GVHD mice, and found that ATO treatment clearly improved the survival of the mice and reduced the severity of GVHD. In addition, ATO reduced the number of F4/80+iNOS+ cells, and increased the number of F4/80+CD206+ cells in the colon of GVHD mice. Furthermore, ATO sharply decreased CD86 and CD80 expression, and increased CD163 and CD206 expression in macrophages induced from aGVHD patients. Therefore,ATO can modulate the M1 and M2 phenotype in GVHD mice or in macrophages from aGVHD patients. Our data suggest that macrophage polarization is involved in the pathogenesis of aGVHD, and ATO treatment modulates macrophage polarization toward an M2 phenotype. | Xiao Liu Yan Su Xueyan Sun Haixia Fu Qiusha Huang Qi Chen Xiaodong Mo Meng Lv Yuan Kong Lanping Xu Xiaojun Huang Xiaohui Zhang | 2020 | Science China(Life Sciences)2020，63，11： | 6 |
| 3 | Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia显示文摘Quantitative metagenomic studies have linked the gut microbiota to autoimmune disorders.Here,we performed deep shotgun metagenomic sequencing of fecal samples from 99 immune thrombocytopenia(ITP)patients and 52 healthy controls.Dysbiosis in the gut microbiome of ITP was detected phylogenetically and functionally,and classifier based on species markers distinguished individuals with ITP from healthy controls.In particular,the abundance of Ruminococcus gnavus,Bifidobacterium longum and Akkermansia muciniphila was markedly increased in treatment-na?ve ITP patients,and the alterations of microbial species were correlated with clinical indices.Functionally,the secondary bile acid biosynthesis and flagellar assembly were depleted in the gut microbiota of ITP,which may contribute to the onset of ITP by affecting the immune system.Furthermore,we found that corticosteroid treatment affected the gut microbiome of ITP.Compared with corticosteroid-sensitive ITP patients,we identified that the corticosteroid-resistant ITP patients displayed a distinct gut microbiome,which was different from that of the treatment-na?ve ITP patients.Together,we provided support for the critical role of gut microbiota in the development of ITP and established a foundation for further research characterizing gut microbiota in relation to corticosteroid resistance of ITP. | Yanan Wang Fengqi Liu Gaochao Zhang Yan Su Xueyan Sun Qi Chen Chencong Wang Haixia Fu Yun He Xiaolu Zhu Xiao Liu Meng Lv Xiangyu Zhao Xiaosu Zhao Yueying Li Qianfei Wang Xiaojun Huang Xiaohui Zhang | 2021 | Science China(Life Sciences)2021，64，5： | 6 |
| 4 | Characterization of proteases from the digestive tract of sea cucumber (Stichopus japonicus):High alkaline protease activity显示文摘 | Fu Xueyan Xue Changhu Miao Benchun | 2005 | Aquaculture2005，246，： | 1 |
| 5 | Characterization ofproteases from the digestive tract of sea cucumber(Stichopus japonicus):high alkaline protease activity显示文摘 | FU Xueyan XUE Changhu MIAO Benchun | 2005 | Aquaculture2005，246，14： | 1 |
| 6 | Reduced MTA1 Expression by RNAi Inhibits in Vitro Invasion and Migration of Esophageal Squamous Cell Carcinoma Cell Line显示文摘 | Haili Qian Ning Lu Liyan Xue Xiao Liang Xueyan Zhang Ming Fu Yongqiang Xie Qimin Zhan Zhihua Liu Chen Lin | 2005 | Clinical & Experimental Metastasis2005，，8： | 1 |
| 7 | Arsenic trioxide (As 2 O 3 ) reduces the invasive and metastatic properties of cervical cancer cells in vitro and in vivo显示文摘 | Jing Yu Haili Qian Yunfeng Li Yang Wang Xueyan Zhang Xiao Liang Ming Fu Chen Lin | 2007 | Gynecologic Oncology2007，，2： | 1 |
| 8 | Effect of processing steps on the physico-chemical properties of dried- seasoned squid显示文摘 | FU Xueyan XUE Changhu MIAO Benchun et a/ | 2007 | Food Chemistry2007，50，3： | 1 |
| 9 | The effects of fucoidans from Laminaria japonica on AAPH mediated oxidation of human low-density lipoprotein显示文摘从有不同硫酸盐内容和分子量的 Laminaria 装饰用的梨树的五 fucoidan 部分被 anion-ex-change 层析和温和的酸水解作用准备。他们偶氮的激进分子上的抗氧化剂效果 2—2''-Azobis (2-amidinopropane ) dihydrochloride (AAPH ) 导致了人的低密度的脂蛋白(LDL ) 的氧化被 monitoringcholesteryl 酉旨水疗院过氧化物(CHL-OOH ) 评估通过反向阶段的高效液体的形成动力学层析(RP-HPLC ) 分析。Fucoidan F - 有 2 000 ~的一个低分子的团的 C 8000 并且 24.3% 的一个硫酸盐内容在亲水基 AAPH 上比另外的 fourfucoidan 部分有许多更强壮的保护的抗氧化剂效果导致的 LDL 氧化。然而,高度 sulfated fucoidan 部分 L - 有一个分子的团的 B 20 000 在保护 LDL 免受 AAPH 的伤害是完全无效的导致的氧化。结果建议分子的质量和 fucoidan 的硫酸盐内容在 AAPH 上在他们的效果起了很重要的作用导致的 LDLoxidation。 | LI Laihao XUE Changhu XUE Yong LI Zhaojie FU Xueyan | 2006 | Acta Oceanologica Sinica2006，25，4： | 0 |
| 10 | Present State And Development Tendency of Research On Modern Theory of Sports Trainology显示文摘To different extents and the threeaspects of sports training principle,event group training theory and specif ic event training theory,the modern theory of sports training has achieved development and gradually formed, the theory system of competitive sports together with the learnings of sports ta1ents indentificaion,sports competition,and management of copetitive sports. The researches on the training of competitive ability, the process of sports training and the social factors affecting training competition has developed in depth, with some new reseach focuses having come into being. A wide,deep involvement of modern science and technology into the development of theory and prac tice of sports training has become an importannt phenomenon and a significant tendency. | TIAN Maijiu SUN Zhian YU Xiangui WANG Qing LU Enchun FU Xueyan(56 years old, PhD. professor) | 1995 | 北京体育大学学报1995，18，S2： | 0 |
| 11 | 抑癌基因RASSF1在胃癌中的表达及临床意义(英文)显示文摘调查表示的目的失去二种类型的率不同 RASSF1 抄本 RASSF1A,在胃癌、良性的胃的疾病和 discuss 的 RASSF1B 他们与临床的意义的关系。RASSF1A 和 RASSF1B 的 mRNA 表情被 RT-PCR 在 32 个病人检测与的方法胃癌, 32 与有良性的胃的疾病的邻近的非癌的胃的纸巾和 51 个案例(包括 30 长期的浅胃炎和 21 长期的萎缩性胃炎) 。结果抄本 A 和 B 在的表示损失的率胃癌是59.3%( 19/32 )并且28.2%( 9/32 ),10%( 3/30 )并且6.7%( 2/30 )在长期的浅胃炎( CSG ),28.6%( 6/21 )并且14.3%( 3/21 )在长期的萎缩性胃炎( CAG )分别地。抄本 A 和 B 在的表示损失的率邻近非癌是 0。RASSF1A 和 RASSF1B mRNA 表情没与不同等级有统计关系胃癌。二不同 RASSF1 抄本 RASSF1A 和 RASSF1B 几乎在邻近的非癌的胃的纸巾被表示的结论。RASSF1A 有重要表示损失在胃癌,并且没与不同等级有统计关系胃癌。结果显示 RASSF1A 是一 suppress 或基因。 | Xueyan Li Baoyu Fu Chaosheng Lin | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 0 |
| 12 | The therapy and mechanisms of replication-deficient recombinant adenovirus Ad-p14ARF in hepatocellular carcinoma显示文摘Objective: To study the therapeutic effect and mechanisms of recombinant adenovirus Ad-p14ARF in hepatocel- lular carcinoma cell lines. Methods: Morphology and trypan blue assay were adopted to evaluate the proliferation of different liver cancer cells after Ad-p14ARF infection. Cell apoptosis was confirmed by detecting phosphatidylserine (PS) externaliza- tion with Annexin V/PI double staining. Western blotting assay analyzed the expression of related proteins. Subcutaneous tumor model of BEL7402 was established to evaluate the therapeutic ability of Ad-p14ARF. Results: Ad-p14ARF suppressed cell growth, proliferation and promoted cell apoptosis of cancer cell lines with different genetic background. Ad-p14ARF in- hibited growth of liver cancer cells (HepG2, BEL7402) in a dose-dependent manner. Ad-p14ARF leaded to overexpression of Bax and p21, which were the downstream regulating genes of p53. Ad-p14ARF suppressed tumor growth significantly in the experimental therapy in nude mice bearing subcutaneous tumor of BEL7402. Conclusion: P14ARF gene is a powerful tumor suppressor gene to be used in cancer gene therapy. It may play an important role in gene therapy against the malignancies in the future. | Haili Qian Haifeng Song Xueyan Zhang Xiao Liang Ming Fu Chen Lin | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，1： | 0 |
| 13 | Purification and characterization of lipoxygenase from Entermorpha clathrata显示文摘The purification and characterization of lipoxygenase (LOX,EC 1.13.11.12) from the green algae Enteromorpha clathrata were studied. Two components marked LOX-1 and LOX-2 were purified and their molecular masses were estimated to be 102 and 79 ku by SDS-PAGE. Both LOX-1 and LOX-2 were stable over the pH wide range 6.0~10.0 and had the optimum pH of 10.0 and 8.6,at optimum temperature of 30 and 25℃,respectively. Substrate specificities of LOX-1 and LOX-2 were the greatest towards linoleic acid,followed by arachidonic acid and linolenic acid. The Michaelis constant values of LOX-1 and LOX-2 were 0.23 and 0.20 mmol/dm3 with the substrate of linoleic acid. The LOX activities were stimulated greatly by Ca2+ but inhibited by Hg2+ and the antioxidants such as BHA,BHT and TBHQ. The hydroperoxide products of LOX were analysed by HPLC with the substrate of methyl linoleate,and the results showed that LOX-1 formed mainly 9-hydroperoxides while LOX-2 formed both 9-and 13-hydroperoxides at a ratio of 24∶76. | YANG Wenge XUE Changhu XU Dalun FU Xueyan HE Xiong | 2008 | Acta Oceanologica Sinica2008，27，1： | 0 |
| 14 | SiRAP2-12,a Positive Regulatory Factor,Effectively Improves the Waterlogging Tolerance of Foxtail Millet(Setaria italica)显示文摘Foxtail millet(Setaria italica)growth was inhibited because of waterlogging stress,which has caused yield reduc-tion.ERF family plays an important role to plant adversity tolerance.In our study,we obtained 19,819 differential expressed genes(DEGs)between the two treatments based on the RNA-seq sequencing of foxtail millet of water-logging stress.Furthermore,a total of 28 ERF family members were obtained,which have a complete open read-ing frame.We studied the evolution and function of SiERF family and how they affected the waterlogging tolerance.It was found that SiERF1A/B/C(GenBank ID:OR775217,OR775219,OR775218)and SiRAP2-12(GenBank ID:OR775216)have similar functions to the known waterlogging tolerance genes of other plants.Among them,the SiRAP2-12 expression was obviously significantly up-regulated in foxtail millet after 5d water-logging stress.After SiRAP2-12 was silenced,the activity of defense enzymes in millet decreased significantly.In details,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD),the osmotic regulator proline(Pro),and the activity of the anaerobic respiratory enzyme alcohol dehydrogenase(ADH)content were decreased by 78.61%,29.52%,79.95%,19.41%and 54.77%,respectively.In contrast,the relative electrical conductivity contents(REC),malondialdehyde(MDA),and hydrogen peroxide(H_(2)O_(2))of the foxtail millet subjected to virus-induced gene silencing clearly increased by 1.03-fold,36.09%,and 15.21%,respectively.The content of sodium(Na^(+))in the SiRAP2-12-silenced foxtail millet also increased,but that of potassium(K^(+))decreased.Interestingly,we found that ethylene content was significantly reduced.Further,the SiAOC1 expression,an essential gene for ethylene synthesis,was inhibited in SiRAP2-12-silenced foxtail millet after waterlogging stress.Taken together,we hypothesized that SiRAP2-12 might be a positive regulator of millet tolerance to waterlogging stress. | Xueyan Xia Xiaohong Fu Yu Zhao Jihan Cui Nuoya Xiao Jingxin Wang Yiwei Lu Meihong Huang Cheng Chu Jia Zhang Mengxin Yang Shunguo Li Jianfeng Liu | 2024 | Phyton-International Journal of Experimental Botany2024，93，3： | 0 |
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