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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | 鱼、蛋、牛奶、坚果、蔬菜和水果摄入量大,以及低盐膳食模式与高血压的患病率和控制率相关显示文摘食物对高血压患病率和控制率的影响尚不清晰。本文旨在中国人群中调查鱼、蛋、牛奶、坚果、蔬菜和水果摄入量大以及低盐膳食模式是否与高血压有关。方法:从2012年9月到2014年12月共招募15303名受试者进行病例对照研究,分为高血压组(n=1604)和正常血压组(n=13660),其中高血压组又分为血压控制亚组(n=397)和血压未控制亚组(n=1207)。收集过去1 年里每周平均鱼、蛋、牛奶、坚果、蔬菜、水果和盐摄入量数据。鱼、蛋、牛奶、坚果、蔬菜、水果和盐的平均摄入量分别为117、150、35、20、2100、300和58g/周。 | Yu G Fu H Huang W Zhang N Deng D Li G Lei H | 2019 | 中华高血压杂志2019，27，5： | 2 |
| 3 | The veterinary antibiotic oxytetracycline and Cu influence functional diversity of the soil microbial community 显示文摘 | KONG W D ZHU Y G FU B J | 2006 | Environmental Pollution2006，143，： | 1 |
| 4 | Distribution of the C37 tetra-unsaturated alkenone in Lake Qinghai, China: a potential lake salinity inclicator显示文摘 | Liu W G Liu Z H Fu M Y | 2008 | Geochimica et Cosmoehimiea Acta2008，72，： | 1 |
| 5 | The veterinary antibiotic oxytetracyeline and Cu influence functional diversity of the soil microbial community 显示文摘 | Kong W D Zhu Y G Fu B J | 2006 | Environmental Pollution2006，143，1： | 1 |
| 6 | Multi-modal mesopomus TiO2-ZrO2 composites with high photocatalytic activity and hydrophilicity显示文摘 | ZHOU W LIU K FU H G | 2008 | Nano- technology2008，19，03： | 1 |
| 7 | Studies on the synthesis and antibacterial activities of polymeric quaternary ammonium salts from dimethylaminoethyl methacry- late 显示文摘 | Lu G Q Wu D C Fu R W | 2007 | React Funet Polym2007，67，4： | 1 |
| 8 | Immunohistochemi- eal locaiization of angiotensin Ⅱ receptors (AT1) in the heart with anti-peptide antibodies showing a positive chronotropic effect 显示文摘 | Fu ML Schulze W Wallukat G | 1998 | Receptors Channels1998，6，： | 1 |
| 9 | Concentration and mode of occurrence of trace elements in marine oil shale from the Bilong Co area,northern Tibet,China显示文摘 | FU X G WANG J ZENG Y H TAN F W FENG X L | | 0，，01： | 1 |
| 10 | The Late Triassic rift-related vol- canic rocks from eastern Qiangtang, northern Tibet (China): Age and tectonic implications显示文摘 | Fu X G Wang J Tan F W | 2010 | Gondwana Research2010，17，1： | 1 |
| 11 | Retrograde type A aortic dissection after endovascular stem graft placement for treatment of type B dissection显示文摘 | DONG Z H FU W G WANG Y Q | 2009 | Circulation2009，119，： | 1 |
| 12 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 13 | Stability analysis of the partial double-layer forms derived from the complete double- layer reticulated dome 显示文摘 | Chen W J He Y L Fu G Y | 2001 | Journal of the International Association for Shell and Spatial Structures2001，42，137： | 1 |
| 14 | High-temperature magnetic properties of Fe-based nanocrystalline alloy显示文摘 | PENG K LIU F S FU D F HUANG Z G XU F DU Y W | 2005 | Mater Chem & Phys2005，89，： | 1 |
| 15 | Experimental Investi- gation on Damping Behavior of Normal Joint Surfaces at U- nit Area显示文摘 | FU W P HUANG Y M ZHENG G P | 1993 | Modeling Measurement & Control B1993，51，5： | 1 |
| 16 | The Study of Intelligent Vehicle Navigation Path Based on Behavior Coordination of Particle Swarm 显示文摘 | HAN G N FU W P WANG W | 2016 | Computational Intelligence and Neuroseienee2016，，65： | 1 |
| 17 | Crystal structure and magnetic properties of an infinite chainlike and a tetranuclear bimetallic copper (Ⅱ)-chromium (Ⅲ) complex with bridging cyanide ions显示文摘 | Fu D G Chen J Tan X S Jiang L J Zhang S W Zheng P J Tang W X | 1997 | Inorg Chem1997，36，2： | 1 |
| 18 | Commutators of weighted Hardy operators on R^n显示文摘 | Fu Z W Liu Z G Lu S Z | 2009 | Proc Amer Math Soe2009，137，： | 1 |
| 19 | Predicting truck load spectra under weight limit changes and its application to steel bridge fatigue assessment显示文摘 | COHEN H FU G K DEKELBAB W | 2003 | Journal of Bridge Engineering2003，8，5： | 1 |
| 20 | Human exposure to methylmercury through rice intake in mercury mining areas, Guizhou prov?ince, China显示文摘 | Feng X Li P Qiu G Wang S Li G Shang L Meng B Jiang H Bai W Li Z Fu X | 2008 | Environ Sci Technol2008，42，1： | 1 |
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