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| 1 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 2 | Overexprcssion of tumor necrosis factor- alpha activites both anti and proapoptosis pathways in the myocardium 显示文摘 | Kubota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 2 |
| 3 | Overexpression of tumor necrosis factor - alpha activates both anti - and pro - apoptotic pathways in the myocardium 显示文摘 | Kubota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 1 |
| 4 | Subsurface gas hydrates in the northern Gulf of Mexico显示文摘 | Boswell R Collett T S Frye M | 2012 | Marine and Petroleum Geology2012，34，1： | 1 |
| 5 | Vitamin E biopotency:comparison of various‘natural-derived’and chemically synthesized-tocopherols显示文摘 | Scherf H Machlin L J Frye T M | 1996 | Animal Food Science Technology1996，59，13： | 1 |
| 6 | Epithelial defensins impair adenoviral infection:implication for adenovirus-mediated gene therapy显示文摘 | GROOP R FRYE M WAGNER T O | 1999 | Hum Gene Ther1999，10，6： | 1 |
| 7 | Overexpression of tumor necrosis factor-α activates both anti and pro-apoptotic pathways in the myocardium显示文摘 | Kubota T Miyagishima M Frye C | 2001 | J Mol Cell Cardiol2001，33，： | 1 |
| 8 | Subsurface gas hy- drates in the northern Gulf of Mexico显示文摘 | Boswell R Collett T S Frye M | 2012 | Marine and Petro- leum Geology2012，34，1： | 1 |
| 9 | A dual observer design for global output feedback stabilization of nonlinear systems with low-order and high-order nonlinearities 显示文摘 | Qian C Li J Frye M T | 2009 | Inter- national Journal of Robust and Nonlinear Control2009，19，15： | 1 |
| 10 | Overexpression of tumor necrosis factor-alpha activates both anti- and pro-apoptotic pathways in the myocardium显示文摘 | Kubota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 1 |
| 11 | Vitamin E biopotency:comparison of various 'natural-derived' and chemically synthesized α-tocopherols显示文摘 | Seherf H Maehlin L J Frye T M | 1996 | Animal Food Science Technology1996，59，： | 1 |
| 12 | Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism显示文摘 | Timothy A Kimbrell John T Little Robert T Dunn Mark A Frye Benjamin D Greenberg Eric M Wassermann Jennifer D Repella Aimee L Danielson Mark W Willis Brenda E Benson Andrew M Speer Elizabeth Osuch Mark S George Robert M Post | 1999 | Biological Psychiatry1999，，12： | 1 |
| 13 | Inhibitory effects of com- monly used herbal extracts on UGT1A1 enzyme activity显示文摘 | Mohamed M E F Tseng T Frye R F | 2010 | Xe- nobiotiea2010，40，10： | 1 |
| 14 | Overexpression of tumor necrosisfactor - cactivates both anti and pro - apoptotic pathways in the myocardium显示文摘 | Kubota T Miyagishima M Frye C | 2001 | J Mol Cell Cardiol2001，33，： | 1 |
| 15 | Overexpression of tumor necrosis factor-α activates both anti- and pro-apoptotic pathways in the mlyocardium显示文摘 | Kuhota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 1 |
| 16 | Overexpression of tumor necrosis factoraipha activates both anti-and pro-apoptotic pathways in the myocardium显示文摘 | Kubota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 1 |
| 17 | Ovexexpression of tumor necrosis factor-alpha activates both anti and pro-apoptotic pathways in the myocardium显示文摘 | Kubota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 1 |
| 18 | Subsurface gas hydrates inthe northern Gulf of Mexico显示文摘 | Boswell R Collett T Frye M | 2012 | Marine and Petroleum Geology2012，34，： | 1 |
| 19 | Overexpression of tumor necrosis factor-ct activates both anti-and pro-apoptotic pathways in the myocardium 显示文摘 | Kubota T Miyagishima M Frye CS | 2001 | J Mol Cell Cardiol2001，33，7： | 1 |
| 20 | N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal increases with age in human lens proteins 显示文摘 | Ahmed M U Frye E B Degenhardt T P | 1997 | Biochem J1997，324，： | 1 |
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