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11篇 您的检索式：作者名="Frilander"

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		题名	作者	年代	出处	被引量
	1	Seasonal appetite regula- tion in the anadromous Arctic eharr: evidence for a role of adiposity in the regulation of appetite but not for leptin in signalling adiposity 显示文摘	Friland E Jobling M Bj6rnsson B T	2012	Gen Comp Endocrino12012，178，2：	1
	2	Orienteering competition injuries: injuries incurred in the Finnish Jukola and Venla relay competitions显示文摘	Linko PE Blomberg HK Frilander HM	1997	Br J Sports Med 31: 205- 2081997，，：	1
	3	Fast track hysterectomy 显示文摘	Mφller C Kehlet H Friland S G	2001	Eur J Obstet Gynecol Reprod Biol2001，98，1：	1
	4	Fast track hysterectomy 显示文摘	Mller C Kehlet H Friland SG	2001	Eur J Obstet Gynecol Reprod Biol2001，98，1：	1
	5	Fast track hysterectomy显示文摘	Moiler C Kehlet H Friland SG	2001	Eur J Obstet Gynecol Reprod Biol2001，98，1：	1
	6	Rapid transcriptome characterization for a nonmodel organism using 454 pyrosequencing显示文摘	Vera J C Wheat C W Fescemyer H W Frilander M J Crawford D L		0，，：	1
	7	Fast track hys- terectomy显示文摘	Moller C Kehlet H Friland S G	2001	Eur J Obstet Gynecol Reprod Biol2001，98，1：	1
	8	Fast track hysterectomy 显示文摘	Moiler C Kehlet H Friland SG	2001	Eur J Obstet Gynecol Reprod Bio12001，98，1：	1
	9	Fast track hysterectomy显示文摘	Moiler C Kehlet H Friland SG	2001	Eur J Obstet Gyneeol Reprod Biol2001，98，1：	1
	10	Fast track hysterectomy显示文摘	Miler C Kehlet H Friland S G	2001	European Journal of Obstetrics & Gynecology and Reproductive Biology2001，98，1：	1
	11	Effects of p27^(Kip1)- and p53- shRNAs on kanamycin damaged mouse cochlea显示文摘AIM: To study the effects of adeno-associated virus(AAV) delivered short hairpin RNAs(shR NAs) on adult CD-1 mouse cochlea damaged by aminoglycoside antibiotic kanamycin. METHODS: Three different sh RNAs were designed(p27Kip1, p53 and p27Kip1+p53) and tested in COS cells. A total of 20 adult CD-1 mice were used in the experiment. Mice were divided into five different groups(four animals/group) depending on the AAV-shRNA construct they received and whether they received kanamycin or not. Saline and AAV-EGFP injected animals were used as controls. All constructs were injected through the round window membrane(RWM) into the cochlea. Cochleae were harvested after 1 mo. Apoptosis was detected with Tunel labeling from paraffin-embedded cochlear tissue sections.RESULTS: AAV2/2-p27Kip1-shRNA and AAV2/2-p53-shRNA were tested in COS cells. Western blotting analysis confirmed that both constructs silenced their target genes effectively in the cell culture. AAV2/2-shRNA constructs were injected into the cochlea of CD-1 mice through the intact RWM. Cotransductionn off individual AAV2/2-sh RNAs with AAV2/2-EGFP resulted in EGFP expression in the organ of Corti. Kaannaammyycciinn treatment had no effect on the expression pattern of the EGFP. AAV2/2-sh RNA treated mice(either with p53 or p27Kip1 and p53 together) showed fewer apoptotic hair cells in the cochlea than the control group(P < 0.05; AAV2/2-p53-shRNA vs saline P = 0.00014; AAV2/2-p27+p53-shRNA vs saline P = 0.0011). AAV2/2-p27-shRNA injected cochleae showed no significant difference in the number of apoptotic cells when compared to the saline injected cochleae.CONCLUSION: Silencing of p53 protein in the kanamycin treated ears may decrease cell death in the organ of Corti.	Laura Pietola Jussi Jero Reetta Jalkanen Teemu J Kinnari Olga Jero Mikko Frilander Katri Pajusola Marjo Salminen Antti A Aarnisalo	2012	World Journal of Otorhinolaryngology2012，2，1：	0

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