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	题名	作者	年代	出处	被引量
1	AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。	Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校)	2016	实用药物与临床2016，19，10：	37
2	Maintaining remission of ulcerative colitis with the prohiotic escherichia coil nissle 1917 is as effective as with standard mesalazine 显示文摘	Kruis W Fric P Pokrotnieks J	2004	Gut2004，53，11：	1
3	Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine显示文摘	Kruis W Fric P Pokrotnieks J	2004	Gut2004，53，11：	1
4	Double-blind comparison of an oral Escherichia coliprepration and mesalazine in maintaining remission of ulcerative colitis显示文摘	Kruis W Schtz E Fric P	1997	Aliment Pharmacol Ther1997，11，：	1
5	Maintaining remission of ulcerative colitis with the probiotic Eschefichia call Nissle 1917 is as effective as with standard mesalazine显示文摘	Kruis W Fric P Pokrotnieks J	2004	Gut2004，53，11：	1
6	Ultrasound estimation of volume of pleural fluid in mechanically ventilated patients显示文摘	M Balik P Plasil P Waldauf J Pazout M Fric M Otahal J Pachl	2006	Intensive Care Medicine2006，，：	1
7	Maintaining remission of ulcerative colitis with the probiotic Escherichia cali Nissle 1917 is as effective as with standard mesalazine 显示文摘	Kruis W Fric P Pokrotnieks J	2004	Gut2004，53，11：	1
8	Frequent intravenous pulses of growth hormone together with glutamine supplementation in prolonged critical illness after multiple trauma:effects on nitrogen balance,insulin resistance,and substrate oxidation显示文摘	Duska F Fric M Waldauf P	2008	Crit Care Med2008，36，6：	1
9	Different expression of some molecular markers in sporadic cancer of the left and right colon显示文摘	Fric P Sovova V Sloncova E	2000	Eur J Cancer Prey2000，9，4：	1
10	Probiotics in Gastroenterology显示文摘	Fric P	2002	Gastroenterology2002，40，：	1
11	Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine 显示文摘	Kruis W Fric P Pokrotnieks J	2004	Gut2004，53，11：	1
12	Maintaining remission of ulcerativecolitiswith the probiotic Escherichia coli Nissle 1917 is as effective as with standardmesalazine显示文摘	KruisW Fric P Pokrotnieks J	2004	Gut2004，53，11：	1
13	Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis 显示文摘	Kruis W Schutz E Fric P	1997	Aliment Pharmacol Ther1997，11，：	1
14	Maintaining remission of ulcer- ative colitis with the probiotic Eschefichia coli Nissle 1917 is as ef- fective as with standard mesalazine 显示文摘	Kruis W Fric P Pohrotnicks J	2004	Gut2004，53，：	1
15	Maintaining remission of ul- cerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine 显示文摘	Kruis W Fric P Porkrotnieks J	2004	Gut2004，53，11：	1
16	Changes of E-cadherin and beta-catenin in human and mouse intestinal tumours显示文摘	Sloncova E Fric P Kucerova D	2001	Histochem J2001，33，1：	1
17	Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine显示文摘	Kruis W Fric P Pokrotnieks J	2004	Gut2004，53，11：	1
18	Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard measalazine 显示文摘	Kruis W Fric P Pokrotnieks J	2004	Gut2004，53，11：	1
19	Maintaining remission of ulcerative colitis with the probiotie Escherichia coli Nissile 1917 is as effective as with standard mesalazine显示文摘	Kruis W Fric P Pokrotnicks J	2006	Gut2006，12，37：	1
20	Maintaining remission of ulcerative colitis with the probiotic Escherichia coil Nissle 1917 is as effective as with standard mesalazine显示文摘	Kruis W Fric P Pokrotnieks J	2004	Gut2004，53，11：	1

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