|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nutritional support teams increase percutaneous endoscopic gastrostomy uptake in motor neuron disease显示文摘AIM:To examine factors influencing percutaneous endoscopic gastrostomy(PEG) uptake and outcomes in motor neuron disease(MND) in a tertiary care centre.METHODS:Case notes from all patients with a confirmed diagnosis of MND who had attended the clinic at the Repatriation General Hospital between January 2007 and January 2011 and who had since died,were audited.Data were extracted for demographics(age and gender),disease characteristics(date of onset,bulbar or peripheral predominance,complications),date and nature of discussion of gastrostomy insertion,nutritional status [weight measurements,body mass index(BMI)],date of gastrostomy insertion and subsequent progress(duration of survival) and quality of life(QoL) [Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised(ALSFRS-R)].In addition,the type of clinician initiating the discussion regarding gastrostomy was recorded as Nutritional Support Team(involved in providing nutrition input viz Gastroenterologist,Speech Pathologist,Dietitian) and other(involved in non-nutritional aspects of patient care).Factors affecting placement and outcomes including length of survival,change in weight and QoL were determined.RESULTS:Case records were available for all 86 patients(49 men,mean age at diagnosis 66.4 years).Thirty-eight patients had bulbar symptoms and 48 had peripheral disease as their presenting feature.Sixty-six patients reported dysphagia.Thirty-one patients had undergone gastrostomy insertion.The major indications for PEG placement were dysphagia and weight loss.Nine patients required immediate full feeding,whereas 17 patients initially used the gastrostomy to supplement oral intake,4 for medication administration and 1 for hydration.Initially the PEG regime met 73% ± 31% of the estimated total energy requirements,increasing to 87% ± 32% prior to death.There was stabilization of weight in patients undergoing gastrostomy [BMI at 3 mo(22.6 ± 2.2 kg/m 2) and 6 mo(22.5 ± 2.0 kg/m 2) after PEG placement compared to weight at the time of the procedure(22.5 ± 3.0 kg/m 2)].However,weight loss recurred in the terminal stages of the illness.There was a strong trend for longer survival from diagnosis among MND in PEG recipients with limb onset presentation compared to similar patients who did not undergo the procedure(P = 0.063).Initial discussions regarding PEG insertion occurred earlier after diagnosis when seen by nutrition support team(NST) clinicians compared to other clinicians.(5.4 ± 7.0 mo vs 11.9 ± 13.4 mo,P = 0.028).There was a significant increase in PEG uptake(56% vs 24%,P = 0.011) if PEG discussions were initiated by the NST staff compared to other clinicians.There was no change in the ALSFRS-R score in patients who underwent PEG(pre 34.1 ± 8.6 vs post 34.8 ± 7.4),although in non-PEG recipients there was a nonsignificant fall in this score(33.7 ± 7.9 vs 31.6 ± 8.8).Four patients died within one month of the procedure,4 developed bacterial site infection requiring antibiotics and 1 required endoscopic therapy for gastric bleeding.Less serious complications attributed to the procedure included persistent gastrostomy site discomfort,poor appetite,altered bowel function and bloating.CONCLUSION:Initial discussion with NST clinicians increases PEG uptake in MND.Gastrostomy stabilizes patient weight but weight loss recurs with advancing disease. | Lin Zhang Leanne Sanders Robert JL Fraser | 2012 | World Journal of Gastroenterology2012，18，44： | 6 |
| 2 | Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis显示文摘 | Hu X Yu SP Fraser JL | 2008 | J Thorac Cardiovasc Surg2008，135，4： | 1 |
| 3 | A review of fractures of the atlas vertebra显示文摘 | Sandhu A Fraser RD | 1990 | J Spinal Disord1990，3，： | 1 |
| 4 | Comparison of multi-lineage cells from human adipose tissue and bone marrow显示文摘 | De Ugarte DA Morizono K Elbarbary A Alfonso Z Zuk PA Zhu M Dragoo JL Ashjian P Thomas B Benhaim P Chen I Fraser J Hedrick MH | | 0，，： | 1 |
| 5 | Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infracted heart function via enhanced survival of implanted cells and angiogenesis显示文摘 | Hu X Yu SP Fraser JL | 2008 | J Thorac Cardiovasc Surg2008，135，9： | 1 |
| 6 | Transplantation of hypoxia-pre- conditioned mesenchymal stem ceils improves infarcted heart func- tion via enhanced survival of implanted cells and angiogenesis显示文摘 | Hu X Yu SP Fraser JL | 2008 | J Thorac Cardiovasc Snrg2008，135，4： | 1 |
| 7 | A review of fractures of the atlas vertebra显示文摘 | Fowler JL Sandhu A Fraser RD | 1990 | J Spinal Disord1990，3，1： | 1 |
| 8 | The human HLAspecific monoclonal antibody W6/32 recognizes a discontinuous eptiope within the alpha 2 domain of murine H-2Db 显示文摘 | Maziarz RT Fraser J Srominger JL | 1986 | Immunogenetics1986，24，3： | 1 |
| 9 | Transplantation of hypoxia precondi- tioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats 显示文摘 | Wei L Fraser JL Lu ZY | 2012 | Neurobiol Dis2012，46，3： | 1 |
| 10 | Fatigue depresses maximal in vitro skeletal muscle Na+-K+ ATPase activity in untrained and trained individuals 显示文摘 | Fraser SF Li JL | 2002 | Appl Physiol2002，93，5： | 1 |
| 11 | Transplantation of hypoxia precon-di- tioned bone marrowmesenchymal stem ceils enhances angiogenesis and neurogenesis after cerebral ischemia in rats 显示文摘 | Wei L Fraser JL Lu ZY | 2012 | Neurebiol Dis2012，46，3： | 1 |
| 12 | The role of VEGF/VEGFR2 signaling in peripheral stimulation-induced cerebral neurovascular regeneration after ischemic stroke in mice显示文摘 | Li WL Fraser JL Yu SP | 2011 | Exp Brain Res2011，214，： | 1 |
| 13 | Transplantation of hypoxia-preconditioned mesenehymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis显示文摘 | Hu X Ys SP Fraser JL | 2008 | Thorae Cardiovasc Surg2008，135，4： | 1 |
| 14 | Identification of broadly recognized T helper 1 lymphocyte epitopes in an equine lentivirus 显示文摘 | Fraser DG Oaks JL Brown WC | 2002 | Immunology2002，105，3： | 1 |
| 15 | Fatigue depresses maximal in vitro skeletal muscle Na+,K+-ATPase activity in untrained and trained individuals显示文摘 | Fraser SF Li JL | | 0，，05： | 1 |
| 16 | Immune reconstitution prevents continuous equine infectious anemia virus replication in an Arabian foal with severe combined immunodeficiency: lessons for control of lentiviruses显示文摘 | Mealey RH Fraser DG Oaks JL | 2001 | Clin lmmunol2001，101，2： | 1 |
| 17 | Transplantation of hypoxia pre- conditioned bone marrow mesenchymal stem cells enhances an- giogenesis and neurogenesis after cerebral ischemia in rats显示文摘 | Wei L Fraser JL Lu ZY | 2012 | Neurobiol Dis2012，46，3： | 1 |
| 18 | Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells en- hances angiogenesis and neurogenesis after cerebral is- chemia in rats显示文摘 | Wei L Fraser JL Lu ZY | 2012 | Neurobiol Dis2012，46，3： | 1 |
| 19 | A review of fractures of the atlas vertebra显示文摘 | Fowler JL Sandhu A Fraser RD | 1990 | J Spinal Disord1990，3，1： | 1 |
| 20 | Transplantation ofhypoxia preconditioned l>one marrow mesenchymal stem cellsenhances angiogenesis and neurogenesis after cerebral ischemiain rats 显示文摘 | WEI L FRASER JL LU ZY | 2012 | Neurobiol Dis2012，46，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员