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| 1 | Liver Involvement in Obese Children (Ultrasonography and Liver Enzyme Levels at Diagnosis and During Follow-up in an Italian Population)显示文摘 | Maria Carmela Saviano Francesco Brunetti Armido Rubino Adriana Franzese Pietro Vajro Alessandro Argenziano Alessandro Puzziello Maria Pina Iannucci | 1997 | Digestive Diseases and Sciences1997，，7： | 3 |
| 2 | Impact of radiogenomics in esophageal cancer on clinical outcomes: A pilot study显示文摘BACKGROUND Esophageal cancer(ESCA)is the sixth most common malignancy in the world,and its incidence is rapidly increasing.Recently,several microRNAs(miRNAs)and messenger RNA(mRNA)targets were evaluated as potential biomarkers and regulators of epigenetic mechanisms involved in early diagnosis.In addition,computed tomography(CT)radiomic studies on ESCA improved the early stage identification and the prediction of response to treatment.Radiogenomics provides clinically useful prognostic predictions by linking molecular characteristics such as gene mutations and gene expression patterns of malignant tumors with medical images and could provide more opportunities in the management of patients with ESCA.AIM To explore the combination of CT radiomic features and molecular targets associated with clinical outcomes for characterization of ESCA patients.METHODS Of 15 patients with diagnosed ESCA were included in this study and their CT imaging and transcriptomic data were extracted from The Cancer Imaging Archive and gene expression data from The Cancer Genome Atlas,respectively.Cancer stage,history of significant alcohol consumption and body mass index(BMI)were considered as clinical outcomes.Radiomic analysis was performed on CT images acquired after injection of contrast medium.In total,1302 radiomics features were extracted from three-dimensional regions of interest by using PyRadiomics.Feature selection was performed using a correlation filter based on Spearman’s correlation(ρ)and Wilcoxon-rank sum test respect to clinical outcomes.Radiogenomic analysis involvedρanalysis between radiomic features associated with clinical outcomes and transcriptomic signatures consisting of eight N6-methyladenosine RNA methylation regulators and five up-regulated miRNA.The significance level was set at P<0.05.RESULTS Of 25,five and 29 radiomic features survived after feature selection,considering stage,alcohol history and BMI as clinical outcomes,respectively.Radiogenomic analysis with stage as clinical outcome revealed that six of the eight mRNA regulators and two of the five up-regulated miRNA were significantly correlated with ten and three of the 25 selected radiomic features,respectively(-0.61<ρ<-0.60 and 0.53<ρ<0.69,P<0.05).Assuming alcohol history as clinical outcome,no correlation was found between the five selected radiomic features and mRNA regulators,while a significant correlation was found between one radiomic feature and three up-regulated miRNAs(ρ=-0.56,ρ=-0.64 andρ=0.61,P<0.05).Radiogenomic analysis with BMI as clinical outcome revealed that four mRNA regulators and one up-regulated miRNA were significantly correlated with 10 and two radiomic features,respectively(-0.67<ρ<-0.54 and 0.53<ρ<0.71,P<0.05).CONCLUSION Our study revealed interesting relationships between the expression of eight N6-methyladenosine RNA regulators,as well as five up-regulated miRNAs,and CT radiomic features associated with clinical outcomes of ESCA patients. | Valentina Brancato Nunzia Garbino Lorenzo Mannelli Marco Aiello Marco Salvatore Monica Franzese Carlo Cavaliere | 2021 | World Journal of Gastroenterology2021，27，36： | 3 |
| 3 | Vitamin E Treatment in Pediatric Obesity-Related Liver Disease: A Randomized Study显示文摘 | Pietro Vajro Claudia Mandato Adriana Franzese Edmondo Ciccimarra Stefania Lucariello Marcella Savoia Grazia Capuano Fiorella Migliaro | 2004 | Journal of Pediatric Gastroenterology and Nutrition2004，，1： | 2 |
| 4 | Modulation of the CD8^+ T - cell response by CD4^+ CD25^+ regulatory T cells in patients with hepatitis B virus infection 显示文摘 | Franzese O Kennedy PT Gehring A J | 2005 | J Virol2005，79，6： | 1 |
| 5 | Diagnosis and surgical man- agement of nasopalatine duct cysts 显示文摘 | Ellioft KA Franzese CB Pitman KT | 2004 | laryngoscope2004，114，8： | 1 |
| 6 | Assessing theenvironmental performance and sustainability of bioenergyproduction in Sweden: A life cycle assessment perspective显示文摘 | Buonocore E Franzese P P Ulgiati S | 2012 | Energy2012，，37： | 1 |
| 7 | Sustainable biomass production: a comparison between gross energy requirement and emergy synthesis methods 显示文摘 | Franzese P P Rydberg T Russo G F | 2009 | Ecological indicators2009，9，5： | 1 |
| 8 | Modμlation of the CD8+ T cell response by CD4^+CD25^+ regμlatory T cells in patients with hepatitis B virus Infection显示文摘 | Franzese O Kennedy P T Gehring A J | 2005 | J Virol2005，79，： | 1 |
| 9 | Pilot study of an objective strured dlinical ex-araination ('the Six Pack')for evaluating clinicalcompetencies 显示文摘 | Franzese CB | 2008 | Otolaryngol head neck surg2008，138，2： | 1 |
| 10 | Modulation of the CD8 + T cell response by CD4 + CD25 + regulatory T cells in patients with hepatitis B virus infection 显示文摘 | Franzese O Kennedy PT Gehring A J | 2005 | J Virol2005，79，6： | 1 |
| 11 | Sustainable biomass production: A comparison between gross energy requirement and emergy synthesis methods 显示文摘 | P P FRANZESE T RYDBERG G F RUSSO | 2009 | Ecological Indicators2009，9，5： | 1 |
| 12 | Modulation of the CD8^+ T cell reponse by CD4^+CD25^+ regulatory T cells in patients with the patitis B virus infection显示文摘 | Franzese O Kennedy PT C ehring A J | 2005 | J Virol2005，79，6： | 1 |
| 13 | Modulation of the CD8^+ - T - cell response by CD4 ^+ CD25 ^+ regulatory T cells in patients with hepatitis B virus infeetion显示文摘 | Franzese O Kennedy PT Gehring A J el al | 2005 | Virol2005，79，： | 1 |
| 14 | Pilot study of an objective structured clinical examination (' the Six Pack') for evaluation clinical competencies显示文摘 | Franzese CB Jackson MS | 2008 | Otolaryngology-Head and Neck Surgery2008，138，： | 1 |
| 15 | Modulation of the CD8 + -T-cell response by CD4 + CD25 + regulatory T ceils in patients with hepatitis B virus infection 显示文摘 | Franzese O Kennedy PT Gehring AJ | 2005 | J Virol2005，79，6： | 1 |
| 16 | Inappro- priate tall stature and renal ectopy in a male patient with X-linked congenital adrenal hypoplasia due to a novel missense mutation in the DAX-1 gene 显示文摘 | Franzese A Brunetti-Pierri N Spagnuolo MI | 2005 | Am J Med Genet A2005，135，1： | 1 |
| 17 | Lagrangian stochastic modeling of a fluctuating plume in the convective boundary layer显示文摘 | FRANZESE P | 2003 | Atmospheric Environment2003，37，12： | 1 |
| 18 | Modulation of the CD8^+ T cell response by CD4^+ CD25^+ regulatory T cells in patients with hepatitis B virus infection显示文摘 | Franzese O Kennedy P T Gehring A J | 2005 | J Virol2005，79，： | 1 |
| 19 | Modulation of the CDS+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection显示文摘 | Franzese O Kennedy PT Gehring AJ | 2005 | J Virol2005，79，6： | 1 |
| 20 | The patient with allergies 显示文摘 | Franzese CB Burkhalter NW | 2010 | Med Clin North Am2010，94，5： | 1 |
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