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| 1 | Surveillance for early diagnosis of hepatocellular carcinoma: How best to do it?显示文摘Surveillance for hepatocellular carcinoma(HCC)is considered a standard of care for patients with chronic liver disease who are at risk of developing this malignancy.Several studies have shown that surveillance can improve the prognosis of patients diagnosed with HCC through an increased likelihood of application of curative or effective treatments.Repetition of liver ultrasonography(US)every 6 mo is the recommended surveillance program to detect early HCCs,and a positive US has to entrain a well-defined recall policy based on contrast-enhanced,dynamic radiological imaging or biopsy for the diagnosis of HCC.Although HCC fulfills the accepted criteria regarding cost-effective cancer screening and surveillance,the implementation of surveillance in clinical practice is defective and this has a negative impact on the cost-effectiveness of the procedure.Education of both physicians and patients is of paramount importance in order to improve the surveillance application and its benefits in patients at risk of HCC.The promotion of specific educational programs for practitioners,clinicians and patients is instrumental in order to expand the correct use of surveillance in clinical practice and eventually improve HCC prognosis. | Edoardo G Giannini Alessandro Cucchetti Virginia Erroi Francesca Garuti Federica Odaldi Franco Trevisani | 2013 | World Journal of Gastroenterology2013，19，47： | 10 |
| 2 | Starting glargine in insulin-nave type 2 diabetic patients based on body mass index is safe显示文摘AIM:To evaluate the safety of four insulin titration algorithms in a homogeneous population of insulin-na ve type 2 diabetic patients.METHODS:We conducted a 24-wk,open,single-center study with 92 insulin-na ve type 2 diabetes patients who failed treatment with one or two oral drugs.The patients were randomized to one of the four following algorithms:LANMET(n=26)and LANMET PLUS(n=22)algorithms,whose patients received a fixed initial insulin dose of 10 U,and DeGold(n=23)and DeGold PLUS(n=21)algorithms,whose patients’initial insulin dose was based on their body mass index(BMI).In addition,patients in the PLUS groups had their insulin titrated twice a week from 2 to 8 U.In the other two groups,the titration was also performed also twice a week,but in a fixed increments of 2 U.The target fasting glucose levels for both groups was 100 mg/dL.RESULTS:There was no significant difference in efficacy parameters.There was no significant difference when comparing moderate hypoglycemia events in algorithms starting with a 10 U fixed dose and algorithms based on BMI.However,there was a significant increase in moderate hypoglycemia events among the PLUS treated patients when the LANMET and DeGold algorithms were compared with the 2 fast-titration PLUS algorithms.We observed 12 hypoglycemia events in the first group,which corresponded to 0.94 events/patient per year,and we observed 42 events in the second group,which corresponded to 2.81 events/patient per year(P<0.037).No further significant differences were observed when other comparisons between the algorithms were carried out.CONCLUSION:Starting insulin glargine based on BMI is safe,but fast titration algorithms increase the risk of moderate hypoglycemia. | Denise R Franco Juliana Baptista Fatima RM Abreu Risoneide B Batista Freddy G Eliaschewitz | 2014 | World Journal of Diabetes2014，5，1： | 2 |
| 3 | Bipolar transurethral resection of prostate: clinical and urodynamic evaluation显示文摘 | Iori F Franco G Leonardo C Laurenti C Tubaro A D-Amico F | 2008 | Urology2008，71，： | 1 |
| 4 | Time-dependent strength and creep in masonry 显示文摘 | Parsekian G A Franco L S | 2006 | TMS Journal2006，24，1： | 1 |
| 5 | High incidence of benign testicular neoplasms diagnosed by ultrasound显示文摘 | Luca C Franco G Giacomo G | 2003 | J Urol2003，170，5： | 1 |
| 6 | Bipolar transurethral resection of prostate: clinical and urodynamic evaluation 显示文摘 | IORI F FRANCO G LEONARDO C | 2008 | Urology2008，71，2： | 1 |
| 7 | Distributed architectures and logical-task decomposition in multimedia surveillance systems显示文摘 | Lucio M Franco O Foresti G L | 2001 | Proceedings of the IEEE2001，89，10： | 1 |
| 8 | Comparison of relative mandibular growth vectorswith high-resolution 3-dimensional imaging显示文摘 | Cevidanes LH Franco AA Gerig G | 2005 | Am J Orthod DentofacialOrthop2005，128，1： | 1 |
| 9 | Suppressors of cytokine signalin regulate angiotensin II-activated Janus kinase-signal transducers and activators of transcription pathway in renal cells显示文摘 | HEMANDEZ VARGAS P LOPEZ FRANCO O SANJUAN G | 2005 | J Am Soc Nephrol2005，16，6： | 1 |
| 10 | Electro oxidation of methanol and ethanol on Pt-Ru/C and Pt-Ru-Mo/C electrocatalysts prepared by Bonnemann' s method 显示文摘 | Oliveira N A Franco G E Arico E | 2003 | Journal of the European Ceramic Society2003，23，： | 1 |
| 11 | Follicular loss in endoscopic surgery for ovarian endometriosis:quantitative and qualitative observations显示文摘 | Romualdi D Franco Zannoni G Lanzone A | | 0，，02： | 1 |
| 12 | A DNA computing inspired computational model显示文摘 | Franco G Margenstern M | 2008 | Theoretical Computer Science2008，404，12： | 1 |
| 13 | Determination of the inertial contribution to the nonlinear refractive index of air, N2, and O2 by use of unfocused high-intensity femtosecond laser pulses显示文摘 | Nibbering E T J Grillon G Franco M A | 1997 | J Opt Soc Am B1997，14，3： | 1 |
| 14 | Medley GF (2004) The reinfection threshold promotes variability in tuberculosis epidemiology and vaccine efficacy显示文摘 | Gomes M G Franco A O Gomes M C | 2004 | Proceedings of the Royal Society B Biological Sciences2004，271，： | 1 |
| 15 | Microstructured-core optical fibre for evanescent wave gas sensing显示文摘 | Cordeiro C M B Franco M A R Chesinil G | 2006 | Optics Express2006，14，13： | 1 |
| 16 | Frequency of adhesive factors and enterotoxins in strains of Escherichia coli isolated from piglets with diarrhea 显示文摘 | FLORES- ABUXAPQUI J J SUAREZ- HOIL G J PUC- FRANCO M A | 1997 | Rev Latinoam Microbiol1997，39，34： | 1 |
| 17 | Clinical and pressure-flow chan-ges after long-term treatment with alfuzosin SR显示文摘 | DeNunzio C Franco G Iori F | 2003 | Urol Int2003，71，1： | 1 |
| 18 | Expression d COX- 1,(213X- 2, and inducible nitricoxide synthase protein in human gastric antrum with Helicobacter pylon infection显示文摘 | Franco L Talaminl G Carra G | 1999 | Prostaglandins Other Lipid Mediat1999，58，1： | 1 |
| 19 | Systemic acquired resistance in crop protection: from nature to a chemical approach显示文摘 | Franco G | 2003 | Journal of Agricultural Food Chemistry2003，51，16： | 1 |
| 20 | Baseline of butyltin pollution in coastal sediments within the Basque Country (northern Spain), in 2007-2008显示文摘 | Rodriguez J G~ Solaun O Larreta J Segarra M J B Franco J Alonso J I G Sariego C Valencia V Borja A | 2010 | Marine Pollution Bulletin2010，60，1： | 1 |
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