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| 1 | Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date, most patients with HCC are diagnosed at an advanced tumor stage, excluding them from potentially curative therapies (i.e., resection, liver transplantation, percutaneous ablation). Treatments with palliative intent include chemoembolization and systemic therapy. Among systemic treatments, the small-molecule multikinase inhibitor sorafenib has been the only systemic treatment available for advanced HCC over 10 years. More recently, other smallmolecule multikinase inhibitors (e.g., regorafenib, lenvatinib, cabozantinib) have been approved for HCC treatment. The promising immune checkpoint inhibitors (e.g., nivolumab, pembrolizumab) are still under investigation in Europe while in the US nivolumab has already been approved by FDA in sorafenib refractory or resistant patients. Other molecules, such as the selective CDK4/6inhibitors (e.g., palbociclib, ribociclib), are in earlier stages of clinical development, and the c- MET inhibitor tivantinib did not show positive results in a phase III study. However, even if the introduction of targeted agents has led to great advances in patient response and survival with an acceptable toxicity profile, a remarkable inter-individual heterogeneity in therapy outcome persists and constitutes a significant problem in disease management. Thus, the identification of biomarkers that predict which patients will benefit from a specific intervention could significantly affect decision-making and therapy planning. Germ-line variants have been suggested to play an important role in determining outcomes of HCC systemic therapy in terms of both toxicity and treatment efficacy. Particularly, a number of studies have focused on the role of genetic polymorphisms impacting the drug metabolic pathway and membrane translocation as well as the drug mechanism of action as predictive/prognostic markers of HCC treatment. The aim of this review is to summarize and critically discuss the pharmacogenetic literature evidences, with particular attention to sorafenib and regorafenib, which have been used longer than the others in HCC treatment. | Elena De Mattia Erika Cecchin Michela Guardascione Luisa Foltran Tania Di Raimo Francesco Angelini Mario D’Andrea Giuseppe Toffoli | 2019 | World Journal of Gastroenterology2019，25，29： | 8 |
| 2 | Coronary microvasculopathy in heart transplantation: Consequences and therapeutic implications显示文摘Despite the progress made in the prevention and treatment of rejection of the transplanted heart, cardiac allograft vasculopathy(CAV) remains the main cause of death in late survival transplanted patients. CAV consists of a progressive diffuse intimal hyperplasia and the proliferation of vascular smooth muscle cells, ending in wall thickening of epicardial vessels, intramyocardial arteries(50-20 μm), arterioles(20-10 μm), and capillaries(< 10 μm). The etiology of CAV remains unclear; both immunologic and non-immunologic mechanisms contribute to endothelial damage with a sustained inflammatory response. The immunological factors involved are Human Leukocyte Antigen compatibility between donor and recipient, alloreactive T cells and the humoral immune system. The non-immunological factors are older donor age, ischemia-reperfusion time, hyperlipidemia and CMV infections. Diagnostic techniques that are able to assess microvascular function are lacking. Intravascular ultrasound and fractional flow reserve, when performed during coronary angiography, are able to detect epicardial coronary artery disease but are not sensitive enough to assess microvascular changes. Some authors have proposed an index of microcircula-tory resistance during maximal hyperemia, which is calculated by dividing pressure by flow(distal pressure multiplied by the hyperemic mean transit time). Non-invasive methods to assess coronary physiology are stress echocardiography, coronary flow reserve by transthoracic Doppler echocardiography, single photon emission computed tomography, and perfusion cardiac magnetic resonance. In this review, we intend to analyze the mechanisms, consequences and therapeutic implications of microvascular dysfunction, including an extended citation of relevant literature data. | Alessandra Vecchiati Sara Tellatin Annalisa Angelini Sabino Iliceto Francesco Tona | 2014 | World Journal of Transplantation2014，4，2： | 3 |
| 3 | Colorectal cancer metastatic to the breast:A case report显示文摘BACKGROUND Breast metastases from colorectal cancer(CRC)are very uncommon.There is no unanimous consensus regarding the best treatment for this rare condition,and management is,especially in elderly patients,limited to diagnosis and palliative care.Capecitabine,an oral fluoropyrimidine derivative,might be helpful in controlling the disease and may be a treatment option for patients unable to receive more aggressive chemotherapy.CASE SUMMARY We report a case of synchronous massive breast metastasis from CRC in an 85 year old patient who came to the hospital presenting a huge mass originating from the axillary extension of the right breast.A whole body computed tomography also showed a mass in the right colon.The patient underwent a simple right mastectomy along with right hemicolectomy.The resected breast showed massive metastasis from CRC with intense and homogeneous nuclear CDX2 staining,while the colon specimen revealed poorly differentiated adenocarcinoma stage pT4a pN0 pM1(breast)(Tumor Node Metastasis 2017).Three months later she developed a subcutaneous mass at the site of the previous mastectomy.An ultrasound guided biopsy was carried out again and revealed a metastasis from CRC.The patient then started treatment with capecitabine plus bevacizumab,obtaining stable disease(RECIST criteria)and a clinical benefit after 3 mo of therapy.CONCLUSION In our experience,capecitabine and bevacizumab may be a useful treatment option for breast metastases from primary CRC in elderly patients. | Silvia Taccogna Elisa Gozzi Luigi Rossi Davide Caruso Davide Conte Patrizia Trenta Valentina Leoni Silverio Tomao Lucrezia Raimondi Francesco Angelini | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 2 |
| 4 | Genetic analysis and molecular characterisation of laboratory and field mutants of Botryotinia fuckeliana ( Botrytis cinerea ) resistant to QoI fungicides显示文摘 | Rita M De Miccolis Angelini Caterina Rotolo Mario Masiello Stefania Pollastro Hideo Ishii Francesco Faretra | 2012 | Pest Manag Sci2012，，9： | 1 |
| 5 | Assessment of the Genetic Effects of Polymorphisms in the Osteoprotegerin Gene, TNFRSF11B, on Serum Osteoprotegerin Levels and Carotid Plaque Vulnerability显示文摘 | Giuseppe Straface Federico Biscetti Dario Pitocco Giovanni Bertoletti Maria Misuraca Claudio Vincenzoni Francesco Snider Vincenzo Arena Egidio Stigliano Flavia Angelini Luigi Iuliano Stefania Boccia Chiara de Waure Francesco Giacchi Giovanni Ghirlanda And | 2011 | Stroke2011，，： | 1 |
| 6 | Effect of native somatostatin on Sohincter of Oddi motility in patients with acute recurrent pancreatitis A pilot stuay with Ultmsamd-Secretin test显示文摘 | Francesco VD Angelini G Zoico E | 2006 | Dig Liver Dis2006，38，4： | 1 |
| 7 | Effect of octreotide on sphincter of Oddi motility in patients with acute recurrent pancreatitis:amanometric study显示文摘 | Francesco VD Angelini G Bovo P | 1996 | Dig Dis Sci1996，41，12： | 1 |
| 8 | Cellular re-distribution of flavin-containing polyamine oxidase in differentiating root and mesocotyl of Zea mays L. seedlings显示文摘 | Alessandra Cona Sandra Moreno Francesco Cenci Rodolfo Federico Riccardo Angelini | 2005 | Planta2005，，2： | 1 |
| 9 | Effect of nativeso matostatin on sphincter of oddimotility in patients with acutere-current pancrealitis,a pilot study with ultra-sound-secretin test显示文摘 | Di Francesco V Angelini G Zoico E | 2006 | Dig LiverDis2006，38，4： | 1 |
| 10 | Effects of gabex- ate mesilate, a protease inhibitor, on human sphincter of Oddi motility显示文摘 | Di Francesco V Marriani A Angelini G et a l | 2002 | Dig Dis Sci2002，47，： | 1 |
| 11 | Impact of Hyperthyroidism and Its Correction on Vascular Reactivity in Humans显示文摘 | Raffaele Napoli Bernadette Biondi Vincenzo Guardasole Margherita Matarazzo Francesco Pardo Valentina Angelini Serafino Fazio Luigi Saccà | 2001 | Circulation: Journal of the American Heart Association2001，，25： | 1 |
| 12 | A Clinical Score to Predict the Need for Intraaortic Balloon Pump in Patients Undergoing Coronary Artery Bypass Grafting显示文摘 | Antonio Miceli Simon M.J. Duggan Radek Capoun Francesco Romeo Massimo Caputo Gianni D. Angelini | 2010 | The Annals of Thoracic Surgery2010，，2： | 1 |
| 13 | Alcohol and Smoking as Risk Factors in Chronic Pancreatitis and Pancreatic Cancer显示文摘 | Giorgio Talamini Claudio Bassi Massimo Falconi Nora Sartori Roberto Salvia Laura Rigo Armando Castagnini Vincenzo Di Francesco Luca Frulloni Paolo Bovo Bruna Vaona Giampaolo Angelini Italo Vantini Giorgio Cavallini Paolo Pederzoli | 1999 | Digestive Diseases and Sciences1999，，7： | 1 |
| 14 | Effects of gabexate mesilate,a protease inhibitor,on human sphincter of Oddi motility显示文摘 | Mariani A Angelini G | 2002 | Dig Dis Sci2002，47，： | 1 |
| 15 | Laparo-endoscopic single site cholecystectomy versus standard laparoscopic cholecystectomy: results of a pilot randomized trial显示文摘 | Marco Maria Lirici Andrea Domenico Califano Pierluigi Angelini Francesco Corcione | 2011 | The American Journal of Surgery2011，，1： | 1 |
| 16 | Effect of octreotide on sphincter of Oddi motility inpatients with acute recurrent pancreatitis: a mano-metfic study显示文摘 | Di Francesco V Angelini G Bovo P | 1996 | Dig Dis Sci1996，41，12： | 1 |
| 17 | Laparoscopic total gastrectomy in gastric cancer: Our experience in 92 cases显示文摘 | Francesco Corcione Felice Pirozzi Diego Cuccurullo Pierluigi Angelini Vincenzo Cimmino Anna Settembre | 2013 | Minimally Invasive Therapy & Allied Technologies2013，，5： | 1 |
| 18 | Environmental exposure to benzene, micronucleus formation and polymorphisms in DNA-repair genes: A pilot study显示文摘 | Sabrina Angelini Francesca Maffei Justo Lorenzo Bermejo Gloria Ravegnini Domenica L’Insalata Giorgio Cantelli-Forti Francesco Saverio Violante Patrizia Hrelia | 2012 | Mutation Research - Genetic Toxicology and Environmental Mutagenesis (-)2012，，1： | 1 |
| 19 | Effect of nativeso matostatin on sphincter of oddimotility in patients with aeutere-current pancrealitis, apilot studywithultra-sound-ecretintest显示文摘 | Di Francesco V Angelini G Zoico E | 2006 | Dig Liver Dis2006，38，4： | 1 |
| 20 | Impact of Hyperthyroidism and Its Correction on Vascular Reactivity in Humans显示文摘 | Raffaele Napoli Bernadette Biondi Vincenzo Guardasole Margherita Matarazzo Francesco Pardo Valentina Angelini Serafino Fazio Luigi Saccà | 2001 | Circulation: Journal of the American Heart Association2001，，： | 1 |
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