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| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Shape-Selective Alkylation of Naphthalene and Methylnaphthalene with Methanol over H-ZSM-5 Zeolite Catalyts显示文摘 | Fraenkel D Cherniavsky M Ittah B | 1986 | J Of Catal1986，101，： | 1 |
| 3 | Complexity aspects of guessing prefix codes 显示文摘 | Fraenkel Aviezri S Klein Shmuel T | 1994 | Algorithmica1994，12，： | 1 |
| 4 | Structure of sulfated metal oxides and its correlation with catalytic activity 显示文摘 | Dan Fraenkel | 1997 | Ind Eng Chem Res1997，36，1： | 1 |
| 5 | Patient Treatment Preferences for Osteoporosis 显示文摘 | Liana Fraenkel Barbara Gulanski Dick Wittink | 2006 | Arthritis Rheum2006，55，5： | 1 |
| 6 | Shape-Selective Alkylation of Naphthalene and Methylnaphthalene with Metha- nol over H-ZSM-5 Zeolite Catalysts 显示文摘 | Fraenkel D Cherniavsky M Ittah B | 1986 | J Catal1986，101，2： | 1 |
| 7 | Contribution to the surgery of neurofibrima of the acoustic nerve显示文摘 | Fraenkel J Hunt JR | 1904 | Ann Surg1904，40，8： | 1 |
| 8 | Acid strength of solids probed by catalytic isobutaneconversion 显示文摘 | FRAENKEL D JENTZSCH N R STARR C A’ | 2010 | Journal of Catalysis2010，274，： | 1 |
| 9 | Glucose and gluconate metabo- lism in a mutant ofEscherichia coli leaking gluconate-6- Phosphate dehydrase 显示文摘 | R Zablotny D G Fraenkel | 1967 | Bacteriol1967，，93： | 1 |
| 10 | Tidal current energy technologies显示文摘 | FRAENKEL P L | 2006 | Ibis2006，148，1： | 1 |
| 11 | Lower airways inflammatory response during rhinovirus colds 显示文摘 | Bardin PG Fraenkel DJ Sanderson G | 1995 | lnt Arch Allergy Immunol1995，107，13： | 1 |
| 12 | A prospective, randomized trial of rifampicin-minocyclinecoated and silver-platinum-carbon-impregnated central venous catheters显示文摘 | FRAENKEL D RICKARD C THOMAS P | 2006 | Crit Care Med2006，34，3： | 1 |
| 13 | Role of magnetic resonance imaging in the diagnosis and prognosis of rheumatoid arthritis 显示文摘 | Surer LG Fraenkel L Braithwaite RS | 2011 | Arthritis Care Res (Hoboken)2011，63，： | 1 |
| 14 | Novel and evolving therapies in the treatment of malignant phaeochromoeytoma: ex- perience with the roTOR inhibitor everolimus ( RAD001 ) 显示文摘 | Druee MR Kahsas GA Fraenkel M | 2009 | Horm Metab Res2009，41，9： | 1 |
| 15 | The tide turns for marine current turbines 显示文摘 | Peter Fraenkel | 2000 | International Water Power & Dam Construction2000，，12： | 1 |
| 16 | HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers显示文摘 | Marc L. Mendillo Sandro Santagata Martina Koeva George W. Bell Rong Hu Rulla M. Tamimi Ernest Fraenkel Tan A. Ince Luke Whitesell Susan Lindquist | 2012 | Cell2012，，3： | 1 |
| 17 | A prospective, ran- domized trial of rifampicin - minocycline - coated and silver -platinum -carbon -impregnated central venous catheters 显示文摘 | Fraenkel D Riekard C Thomas P | 2006 | Crit Care Med2006，34，3： | 1 |
| 18 | The raison d'Etre of secondary plant substances 显示文摘 | Fraenkel G S | 1959 | Science1959，129，3361： | 1 |
| 19 | The action 1,2 - epoxieds on proteins 显示文摘 | Fraenkel Conrat H | 1944 | Journal of Bio - logical Chemistry1944，154，： | 1 |
| 20 | Encapsulate hydrogen显示文摘 | FRAENKEL D | 1981 | Chem Tech1981，，1： | 1 |
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