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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | The serine/ threonine kinase Pim-2 is a transcriptionally regulated apopotot-ic inhibitor显示文摘 | FOX C J HAMMERMAN P S CINALLI R M | 2003 | Genes Dev2003，17，15： | 1 |
| 3 | An apparently new transmissible disease of cattle显示文摘 | OLAFSON P MAC C A FOX F H | 1946 | Cornell Vet1946，36，： | 1 |
| 4 | Potential clinical rele-vance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines显示文摘 | FOX B P TABONE C KANDPAL R P | | 0，，04： | 1 |
| 5 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 6 | Isola tion and characterization of six heat shock transcription [actor cDNA clones from soybean显示文摘 | Czarnecka-Verner E Yuan C X Fox P C | | 0，，01： | 1 |
| 7 | Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats显示文摘 | Fox P R Oyama M A Reynolds C | | 0，，1： | 1 |
| 8 | Prediction of ruminal volatile fatty acids and pH within thd net carbohydrate and protein system显示文摘 | Pitt R E Van Kessel J S Fox D G Pell A N Barry M C Van Soest P J | 1996 | Journal of Animal Science1996，74，： | 1 |
| 9 | Soluble nitrogen in cheddar cheese:comparison of extraction procedures显示文摘 | Kuchroo C N Fox P F | 1982 | Milchwissenschaft1982，37，6： | 1 |
| 10 | Soluble nitrogen in cheese:comparison of extraction procedures显示文摘 | KUCHROO C N FOX P F | 1982 | Milchwissenschaft1982，，37： | 1 |
| 11 | Interface interactions between porous titanium/tantalum coatings,produced by selective laser melting (SLM),on a cobalt-chromium alloy显示文摘 | FOX P POGSON S SUTCLIFFE C J | 2008 | Suface & Coating Technology2008，202，20： | 1 |
| 12 | Poly(A) addition during maturation of frog oocytes:distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU 显示文摘 | Fox C A Sheets M D Wickner M P | 1989 | Genes Dev1989，3，： | 1 |
| 13 | Abyssal anti-dunes显示文摘 | Fox P J Heezen B C Harian A M | 1968 | Nature1968，220，： | 1 |
| 14 | Practical aspects of CO2 flooding 显示文摘 | Jarrell P M Fox C Stein M etal | 2002 | SPE Monograph Series2002，22，： | 1 |
| 15 | Traumatic aneurysms of the superficial temporal artery: case report 显示文摘 | FOX J T CORDTS P R GWINN B C 2ND | 1994 | J Trauma1994，36，4： | 1 |
| 16 | Assessment of proteolysis in cheese by reaction with trinityrobenzene sulphonic acid显示文摘 | RAHILLY J FOX P F | 1983 | Irish J Food Sci and Technol1983，7，： | 1 |
| 17 | Strategies for the rapidprenatal diagnosis of chromosome aneuploidy显示文摘 | Mann K Donaghue C Fox S P | 2004 | Eur J HumGenet2004，12，11： | 1 |
| 18 | Expression of the forkhead transcrip- tion factor FOXP1 is associated with estrogen receptor alpha and im- proved survival in primary human breast carcinomas 显示文摘 | Fox SB Brown P Han C | 2004 | Clin Cancer Res2004，10，10： | 1 |
| 19 | Work-related stressand intention to quit in newly graduated nurses 显示文摘 | Wu T Y Fox D P Stokes C | 2012 | Nurse Educ Today2012，32，6： | 1 |
| 20 | Quantification and localization of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection显示文摘 | Ward S M Fox B C Brown P J | 2007 | J Heptol2007，47，： | 1 |
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